Abstract：
:Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are commercially available, while many others with saturated or mono-unsaturated alkyl chains of variable length are not available. These compounds are, however, necessary as standards for analytical methods. Here, we investigated different reported procedures and we adapted some of them to prepare a series of 1-O-alkyl-glycerols featuring mainly saturated alkyl chains of various lengths (14:0, 16:0, 17:0, 19:0, 20:0, 22:0) and two monounsaturated chains (16:1, 18:1). All of these standards were fully characterized by NMR and GC-MS. Finally, we used these standards to identify the AEL subtypes in shark and chimera liver oils. The distribution of the identified AEL were: 14:0 (20-24%), 16:0 (42-54%) and 18:1 (6-16%) and, to a lesser extent, (0.2-2%) for each of the following: 16:1, 17:0, 18:0, and 20:0. These standards open the possibilities to identify AEL subtypes in tumours and compare their composition to those of non-tumour tissues.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Pinault M,Guimaraes C,Couthon H,Thibonnet J,Fontaine D,Chantôme A,Chevalier S,Besson P,Jaffrès PA,Vandier Cdoi
10.3390/md16040101subject
Has Abstractpub_date
2018-03-23 00:00:00issue
4issn
1660-3397pii
md16040101journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Shrimp is one of the most popular seafoods worldwide, and its lipids have been studied for biological activity in both, muscle and exoskeleton. Free fatty acids, triglycerides, carotenoids, and other lipids integrate this fraction, and some of these compounds have been reported with cancer chemopreventive activities. ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11103926
更新日期：2013-10-16 00:00:00
abstract：:There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030059
更新日期：2017-02-28 00:00:00
abstract：:We performed a high-content screening (HCS) assay aiming to discover bioactive molecules with proteasome inhibitory activity. By structural elucidation, we identified six compounds purified from soft coral Clavularia flava, which potentiates proteasome inhibition. Chemical structure elucidation revealed they are dolab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18010039
更新日期：2020-01-03 00:00:00
abstract：:Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110413
更新日期：2018-10-27 00:00:00
abstract：:A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a mo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12125856
更新日期：2014-12-04 00:00:00
abstract：:Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070130
更新日期：2016-07-08 00:00:00
abstract：:The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11041370
更新日期：2013-04-23 00:00:00
abstract：:Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19010003
更新日期：2020-12-23 00:00:00
abstract：:Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 w...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15020043
更新日期：2017-02-17 00:00:00
abstract：:β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13031185
更新日期：2015-03-02 00:00:00
abstract：:D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7010045
更新日期：2009-01-01 00:00:00
abstract：:Sulphated polysaccharides with anti-thrombotic and anti-coagulant activities have been found in various marine biota. In this study, a previously characterised anti-thrombotic and anti-coagulant extract from blacklip abalone was fractionated by anion exchange chromatography (AEC), pooled (on a sulphated polysaccharide...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15080240
更新日期：2017-08-04 00:00:00
abstract：:Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13053103
更新日期：2015-05-19 00:00:00
abstract：:Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ec...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17060320
更新日期：2019-05-30 00:00:00
abstract：:Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18110561
更新日期：2020-11-17 00:00:00
abstract：:In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the cultur...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16070229
更新日期：2018-07-06 00:00:00
abstract：:Drug-resistant Staphylococcus aureus is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple S. aureus strains, including current drug-resistant ones, are needed. Previously, we have described...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10051103
更新日期：2012-05-01 00:00:00
abstract：:The carbonic anhydrase (CA, EC 4.2.1.1) superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15090270
更新日期：2017-08-28 00:00:00
abstract：:Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9091440
更新日期：2011-01-01 00:00:00
abstract：:The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18060327
更新日期：2020-06-23 00:00:00
abstract：:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16120488
更新日期：2018-12-06 00:00:00
abstract：:The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12042164
更新日期：2014-04-10 00:00:00
abstract：:Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17050307
更新日期：2019-05-24 00:00:00
abstract：:Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070228
更新日期：2017-07-18 00:00:00
abstract：:Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120377
更新日期：2017-12-04 00:00:00
abstract：:Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8082318
更新日期：2010-08-11 00:00:00
abstract：:Polysaccharides extracted from marine algae have attracted much attention due to their biotechnological applications, including therapeutics, cosmetics, and mainly in agriculture and horticulture as biostimulants, biofertilizers, and stimulators of the natural defenses of plants. This study aimed to evaluate the abili...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100521
更新日期：2020-10-19 00:00:00
abstract：:In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9030294
更新日期：2011-02-25 00:00:00
abstract：:Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110631
更新日期：2019-11-06 00:00:00
abstract：:The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title：Marine drugs
pub_type： 杂志文章,已发布勘误
doi：10.3390/md15090292
更新日期：2017-09-20 00:00:00
