Sea Cucumber Glycosides: Chemical Structures, Producing Species and Important Biological Properties.

Abstract:

:Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holostane and nonholostane depending on the presence or absence of a specific structural unit γ(18,20)-lactone in the aglycone. Triterpene glycosides contain a carbohydrate chain up to six monosaccharide units mainly consisting of d-xylose, 3-O-methy-d-xylose, d-glucose, 3-O-methyl-d-glucose, and d-quinovose. Cytotoxicity is the common biological property of triterpene glycosides isolated from sea cucumbers. Besides cytotoxicity, triterpene glycosides also exhibit antifungal, antiviral and hemolytic activities. This review updates and summarizes our understanding on diverse chemical structures of triterpene glycosides from various species of sea cucumbers and their important biological activities. Mechanisms of action and structural-activity relationships (SARs) of sea cucumber glycosides are also discussed briefly.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Mondol MAM,Shin HJ,Rahman MA,Islam MT

doi

10.3390/md15100317

subject

Has Abstract

pub_date

2017-10-17 00:00:00

issue

10

issn

1660-3397

pii

md15100317

journal_volume

15

pub_type

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