Comparative Analysis of Culture Conditions for the Optimization of Carotenoid Production in Several Strains of the Picoeukaryote Ostreococcus.


:Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such as lipids, polysaccharides or carotenoid pigments. Studying carotenogenesis is important for deciphering the mechanisms of adaptation to stress tolerance as well as for biotechnological production. In recent years, the picoeukaryote Ostreococcustauri has emerged as a model organism thanks to the development of powerful genetic tools. Several strains of Ostreococcus isolated from different environments have been characterized with respect to light response or iron requirement. We have compared the carotenoid contents and growth rates of strains of Ostreococcus (OTTH595, RCC802 and RCC809) under a wide range of light, salinity and temperature conditions. Carotenoid profiles and productivities varied in a strain-specific and stress-dependent manner. Our results also illustrate that phylogenetically related microalgal strains originating from different ecological niches present specific interests for the production of specific molecules under controlled culture conditions.


Mar Drugs


Marine drugs


Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY




Has Abstract


2018-02-28 00:00:00










  • Asymmetric Total Synthesis of Ieodomycin B.

    abstract::Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 positions via a Crimmins-mo...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lin S,Zhang J,Zhang Z,Xu T,Huang S,Wang X

    更新日期:2017-01-18 00:00:00

  • Optimization of Collagenase Production by Pseudoalteromonas sp. SJN2 and Application of Collagenases in the Preparation of Antioxidative Hydrolysates.

    abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

    更新日期:2017-12-04 00:00:00

  • Physical Properties, Chemical Analysis, and Evaluation of Antimicrobial Response of New Polylactide/Alginate/Copper Composite Materials.

    abstract::In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA-ALG-Cu2+) composite f...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kudzin MH,Boguń M,Mrozińska Z,Kaczmarek A

    更新日期:2020-12-21 00:00:00

  • Structure-Based Design and Synthesis of a New Phenylboronic-Modified Affinity Medium for Metalloprotease Purification.

    abstract::Metalloproteases are emerging as useful agents in the treatment of many diseases including arthritis, cancer, cardiovascular diseases, and fibrosis. Studies that could shed light on the metalloprotease pharmaceutical applications require the pure enzyme. Here, we reported the structure-based design and synthesis of th...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Li S,Wang L,Xu X,Lin S,Wang Y,Hao J,Sun M

    更新日期:2016-12-27 00:00:00

  • Suberitamides A-C, Aryl Alkaloids from a Pseudosuberites sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity.

    abstract::Three new aryl alkaloids named suberitamides A-C (1-3), were isolated from an extract of the marine sponge Pseudosuberites sp. collected along the coast of North Carolina. Their planar structures were established by extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. To assign the challengi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kim CK,Wang D,Wilson BAP,Saurí J,Voeller D,Lipkowitz S,O'Keefe BR,Gustafson KR

    更新日期:2020-10-28 00:00:00

  • Whole Genome Sequencing of Chinese White Dolphin (Sousa chinensis) for High-Throughput Screening of Antihypertensive Peptides.

    abstract::Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as "Vulnerable" on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Jia K,Bian C,Yi Y,Li Y,Jia P,Gui D,Zhang X,Lin W,Sun X,Lv Y,Li J,You X,Shi Q,Yi M,Wu Y

    更新日期:2019-08-28 00:00:00

  • Acetylated Triterpene Glycosides and Their Biological Activity from Holothuroidea Reported in the Past Six Decades.

    abstract::Sea cucumbers have been valued for many centuries as a tonic and functional food, dietary delicacies and important ingredients of traditional medicine in many Asian countries. An assortment of bioactive compounds has been described in sea cucumbers. The most important and abundant secondary metabolites from sea cucumb...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Bahrami Y,Franco CM

    更新日期:2016-08-04 00:00:00

  • Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans.

    abstract::Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic ana...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ragini K,Piggott AM,Karuso P

    更新日期:2017-06-15 00:00:00

  • The Marine Fungi Rhodotorula sp. (Strain CNYC4007) as a Potential Feed Source for Fish Larvae Nutrition.

    abstract::Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Barra M,Llanos-Rivera A,Cruzat F,Pino-Maureira N,González-Saldía RR

    更新日期:2017-12-01 00:00:00

  • A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).

    abstract::Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Huang Y,Peng C,Yi Y,Gao B,Shi Q

    更新日期:2017-07-18 00:00:00

  • Bioactive compounds from the Red Sea marine sponge Hyrtios species.

    abstract::In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Youssef DT,Shaala LA,Asfour HZ

    更新日期:2013-03-28 00:00:00

  • Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013.

    abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sheu JH,Chen YH,Chen YH,Su YD,Chang YC,Su JH,Weng CF,Lee CH,Fang LS,Wang WH,Wen ZH,Wu YC,Sung PJ

    更新日期:2014-04-10 00:00:00

  • Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms.

    abstract::Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Citkowska A,Szekalska M,Winnicka K

    更新日期:2019-08-05 00:00:00

  • The Inhibitory Effect of Protamine on Platelets is Attenuated by Heparin without Inducing Thrombocytopenia in Rodents.

    abstract::Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Miklosz J,Kalaska B,Kaminski K,Rusak M,Szczubialka K,Nowakowska M,Pawlak D,Mogielnicki A

    更新日期:2019-09-17 00:00:00

  • Core oligosaccharide of Plesiomonas shigelloides PCM 2231 (Serotype O17) lipopolysaccharide--structural and serological analysis.

    abstract::The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS) P. shigelloides Polish Collection of Microorganisms (PCM) 2231 (serotype O17) was investigated by (1)H, (13)C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is compo...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Maciejewska A,Lukasiewicz J,Kaszowska M,Man-Kupisinska A,Jachymek W,Lugowski C

    更新日期:2013-02-06 00:00:00

  • Fucoxanthin-Containing Cream Prevents Epidermal Hyperplasia and UVB-Induced Skin Erythema in Mice.

    abstract::Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models. Firstly, its anti-inflammatory activity was evaluated in LPS-stimulated THP-1 macrophages...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Rodríguez-Luna A,Ávila-Román J,González-Rodríguez ML,Cózar MJ,Rabasco AM,Motilva V,Talero E

    更新日期:2018-10-10 00:00:00

  • Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis.

    abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xu MJ,Liu XJ,Zhao YL,Liu D,Xu ZH,Lang XM,Ao P,Lin WH,Yang SL,Zhang ZG,Xu J

    更新日期:2012-03-01 00:00:00

  • Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales).

    abstract::Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 μg/mL. In addition...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bouhlal R,Haslin C,Chermann JC,Colliec-Jouault S,Sinquin C,Simon G,Cerantola S,Riadi H,Bourgougnon N

    更新日期:2011-01-01 00:00:00

  • Astaxanthin from Shrimp Cephalothorax Stimulates the Immune Response by Enhancing IFN-γ, IL-10, and IL-2 Secretion in Splenocytes of Helicobacter Pylori-Infected Mice.

    abstract::Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production....

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Davinelli S,Melvang HM,Andersen LP,Scapagnini G,Nielsen ME

    更新日期:2019-06-26 00:00:00

  • Phlorofucofuroeckol A from Edible Brown Alga Ecklonia Cava Enhances Osteoblastogenesis in Bone Marrow-Derived Human Mesenchymal Stem Cells.

    abstract::The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Oh JH,Ahn BN,Karadeniz F,Kim JA,Lee JI,Seo Y,Kong CS

    更新日期:2019-09-21 00:00:00

  • Effect of Methionine Oxidation and Substitution of α-Conotoxin TxID on α3β4 Nicotinic Acetylcholine Receptor.

    abstract::α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ren J,Li R,Ning J,Zhu X,Zhangsun D,Wu Y,Luo S

    更新日期:2018-06-20 00:00:00

  • From Aggregates to Porous Three-Dimensional Scaffolds through a Mechanochemical Approach to Design Photosensitive Chitosan Derivatives.

    abstract::The crustacean processing industry produces large quantities of waste by-products (up to 70%). Such wastes could be used as raw materials for producing chitosan, a polysaccharide with a unique set of biochemical properties. However, the preparation methods and the long-term stability of chitosan-based products limit t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bardakova KN,Akopova TA,Kurkov AV,Goncharuk GP,Butnaru DV,Burdukovskii VF,Antoshin AA,Farion IA,Zharikova TM,Shekhter AB,Yusupov VI,Timashev PS,Rochev YA

    更新日期:2019-01-10 00:00:00

  • Sphaeroane and neodolabellane diterpenes from the red alga Sphaerococcus coronopifolius.

    abstract::Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Smyrniotopoulos V,Vagias C,Roussis V

    更新日期:2009-05-19 00:00:00

  • Impact of DHA on metabolic diseases from womb to tomb.

    abstract::Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Arnoldussen IA,Kiliaan AJ

    更新日期:2014-12-18 00:00:00

  • Sarcophyolides B-E, new cembranoids from the soft coral Sarcophyton elegans.

    abstract::Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Xi Z,Bie W,Chen W,Liu D,van Ofwegen L,Proksch P,Lin W

    更新日期:2013-08-26 00:00:00

  • Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway.

    abstract::TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Liu J,Ma L,Wu N,Liu G,Zheng L,Lin X

    更新日期:2014-09-25 00:00:00

  • Angiotensin-I Converting Enzyme (ACE) Inhibitory and Anti-Hypertensive Effect of Protein Hydrolysate from Actinopyga lecanora (Sea Cucumber) in Rats.

    abstract::Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats with ALP at various ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sadegh Vishkaei M,Ebrahimpour A,Abdul-Hamid A,Ismail A,Saari N

    更新日期:2016-09-30 00:00:00

  • Interactions of the α3β2 Nicotinic Acetylcholine Receptor Interfaces with α-Conotoxin LsIA and its Carboxylated C-terminus Analogue: Molecular Dynamics Simulations.

    abstract::Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wen J,Adams DJ,Hung A

    更新日期:2020-07-03 00:00:00

  • Marinopyrrole derivatives with sulfide spacers as selective disruptors of Mcl-1 binding to pro-apoptotic protein Bim.

    abstract::A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cheng C,Liu Y,Balasis ME,Garner TP,Li J,Simmons NL,Berndt N,Song H,Pan L,Qin Y,Nicolaou KC,Gavathiotis E,Sebti SM,Li R

    更新日期:2014-07-29 00:00:00

  • Antitumor and antimicrobial activity of some cyclic tetrapeptides and tripeptides derived from marine bacteria.

    abstract::Marine derived cyclo(Gly-l-Ser-l-Pro-l-Glu) was selected as a lead to evaluate antitumor-antibiotic activity. Histidine was chosen to replace the serine residue to form cyclo(Gly-l-His-l-Pro-l-Glu). Cyclic tetrapeptides (CtetPs) were then synthesized using a solution phase method, and subjected to antitumor and antibi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chakraborty S,Tai DF,Lin YC,Chiou TW

    更新日期:2015-05-15 00:00:00