Abstract：
:Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interesting relationships with the polyketide endoperoxides found in this sponge. Some semi-synthetic analogues of manadoperoxide B (6-8) were prepared and evaluated for antitrypanosomal activity and cytotoxicity. These studies revealed crucial structure-activity relationships that should be taken into account in the design of optimized and simplified endoperoxyketal trypanocidal agents.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Chianese G,Scala F,Calcinai B,Cerrano C,Dien HA,Kaiser M,Tasdemir D,Taglialatela-Scafati Odoi
10.3390/md11093297subject
Has Abstractpub_date
2013-08-28 00:00:00pages
3297-308issue
9issn
1660-3397pii
md11093297journal_volume
11pub_type
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