MS/MS-Based Molecular Networking Approach for the Detection of Aplysiatoxin-Related Compounds in Environmental Marine Cyanobacteria.

abstract：:Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...

journal_title：Marine drugs

authors： Rodrigues Felix C,Roberts JC,Winder PL,Gupta R,Diaz MC,Pomponi SA,Wright AE,Rohde KH

更新日期：2019-12-16 00:00:00

abstract：:The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...

journal_title：Marine drugs

authors： Konoki K,Onoda T,Watanabe R,Cho Y,Kaga S,Suzuki T,Yotsu-Yamashita M

更新日期：2013-01-29 00:00:00

abstract：:The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...

journal_title：Marine drugs

authors： Xie B,Huang Y,Baumann K,Fry BG,Shi Q

更新日期：2017-03-30 00:00:00

abstract：:The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...

journal_title：Marine drugs

authors： Ermolenko EV,Imbs AB,Gloriozova TA,Poroikov VV,Sikorskaya TV,Dembitsky VM

更新日期：2020-12-02 00:00:00

abstract：:High seafood consumption has traditionally been linked to a reduced risk of cardiovascular diseases, mainly due to the lipid lowering effects of the long chained omega 3 fatty acids. However, fish and seafood are also excellent sources of good quality proteins and emerging documentation show that, upon digestion, thes...

journal_title：Marine drugs

authors： Jensen IJ,Mæhre HK

更新日期：2016-11-18 00:00:00

abstract：:In the last decades, research has focused on the capabilities of microbes to secrete exopolysaccharides (EPS), because these polymers differ from the commercial ones derived essentially from plants or algae in their numerous valuable qualities. These biopolymers have emerged as new polymeric materials with novel and u...

journal_title：Marine drugs

authors： Finore I,Di Donato P,Mastascusa V,Nicolaus B,Poli A

更新日期：2014-05-22 00:00:00

abstract：:Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...

journal_title：Marine drugs

authors： Nicosia A,Maggio T,Mazzola S,Cuttitta A

更新日期：2013-10-30 00:00:00

abstract：:Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the pH dependence of an...

journal_title：Marine drugs

authors： Andrud K,Xing H,Gabrielsen B,Bloom L,Mahnir V,Lee S,Green BT,Lindstrom J,Kem W

更新日期：2019-10-29 00:00:00

abstract：:A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant acti...

journal_title：Marine drugs

authors： Kumar R,Subramani R,Feussner KD,Aalbersberg W

更新日期：2012-01-01 00:00:00

abstract：:Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...

journal_title：Marine drugs

authors： Fang Y,Yang S,Fu X,Xie W,Li L,Liu Z,Mou H,Zhu C

更新日期：2019-03-20 00:00:00

abstract：:Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...

journal_title：Marine drugs

authors： Pateiro M,Munekata PES,Domínguez R,Wang M,Barba FJ,Bermúdez R,Lorenzo JM

更新日期：2020-02-04 00:00:00

abstract：:Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...

journal_title：Marine drugs

authors： Sharifuddin Y,Chin YX,Lim PE,Phang SM

更新日期：2015-08-21 00:00:00

abstract：:In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...

journal_title：Marine drugs

authors： Fu B,Lin H,Ramesh Pavase T,Mi N,Sui J

更新日期：2020-02-26 00:00:00

abstract：:Two new compounds-a trioxilin and a sulfoquinovosyl diacylglycerol (SQDG)-were isolated from the methanolic extract of the heterotrophic dinoflagellate Oxyrrhis marina cultivated by feeding on dried yeasts. The trioxilin was identified as (4Z,8E,13Z,16Z,19Z) -7(S),10(S),11(S)-trihydroxydocosapentaenoic acid (1), and t...

journal_title：Marine drugs

authors： Yoon EY,Yang AR,Park J,Moon SJ,Jeong EJ,Rho JR

更新日期：2017-02-27 00:00:00

abstract：:Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...

journal_title：Marine drugs

authors： Vallet M,Meziane T,Thiney N,Prado S,Hubas C

更新日期：2020-07-22 00:00:00

abstract：:Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...

journal_title：Marine drugs

authors： Elmallah MI,Micheau O

更新日期：2015-11-13 00:00:00

abstract：:Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...

journal_title：Marine drugs

authors： Yang G,Mozzicafreddo M,Ballarini P,Pucciarelli S,Miceli C

更新日期：2021-01-27 00:00:00

abstract：:The effect of gold nanoparticles (GNPs) synthesized in marine algae has been described in the context of skin, where they have shown potential benefit. Ecklonia stolonifera (ES) is a brown algae that belongs to the Laminariaceae family, and is widely used as a component of food and medicine due to its biological activ...

journal_title：Marine drugs

authors： Jun ES,Kim YJ,Kim HH,Park SY

更新日期：2020-08-19 00:00:00

abstract：:Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production....

journal_title：Marine drugs

authors： Davinelli S,Melvang HM,Andersen LP,Scapagnini G,Nielsen ME

更新日期：2019-06-26 00:00:00

abstract：:Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA) (20:5n-3) and docosahexaenoic acid (DHA) (22:6n-3), are considered essential for human health. Microorganisms are the primary producers of omega-3 fatty acids in marine ecosystems, representing a sustainable source of these ...

journal_title：Marine drugs

authors： Estupiñán M,Hernández I,Saitua E,Bilbao ME,Mendibil I,Ferrer J,Alonso-Sáez L

更新日期：2020-02-01 00:00:00

abstract：:Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tissue engineering. Aloe vera extracts were encapsulated inside polymer f...

journal_title：Marine drugs

authors： Zahedi E,Esmaeili A,Eslahi N,Shokrgozar MA,Simchi A

更新日期：2019-01-05 00:00:00

abstract：:In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin have the ability to mediate a quick and efficient hemostatic effect f...

journal_title：Marine drugs

authors： Elsabahy M,Hamad MA

更新日期：2021-01-22 00:00:00

abstract：:Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...

journal_title：Marine drugs

authors： Fang F,Zhao J,Ding L,Huang C,Naman CB,He S,Wu B,Zhu P,Luo Q,Gerwick WH,Yan X,Wang Q,Zhang Z,Cui W

更新日期：2017-08-19 00:00:00

abstract：:Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod Temora longicornis. Production of DMS can rapidly increase following ...

journal_title：Marine drugs

authors： Breckels MN,Bode NW,Codling EA,Steinke M

更新日期：2013-07-15 00:00:00

abstract：:Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...

journal_title：Marine drugs

authors： Turk T,Frangez R,Sepcić K

更新日期：2007-11-13 00:00:00

abstract：:Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and sh...

journal_title：Marine drugs

authors： Barbero H,Díez-Poza C,Barbero A

更新日期：2017-11-15 00:00:00

abstract：:The development of oxidative stress in the marine ecosystem is a concurring concern in fish reproductive behavior. Marine fish being rich in polyunsaturated fatty acids (PUFA) are precursors of prostaglandin pheromone mediators but also vulnerable to lipid peroxidation. It is yet to be determined if hypoxia or hyperox...

journal_title：Marine drugs

authors： Chung ML,Galano JM,Oger C,Durand T,Lee JC

更新日期：2015-04-14 00:00:00

abstract：:Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P.stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus co...

journal_title：Marine drugs

authors： Wu S,Zheng R,Sha Z,Sun C

更新日期：2017-07-10 00:00:00

abstract：:Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...

journal_title：Marine drugs

authors： Miller IJ,Chevrette MG,Kwan JC

更新日期：2017-06-06 00:00:00

abstract：:Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce a sustained increase in cytoplasmic Ca2...

journal_title：Marine drugs

authors： García F,Lobos P,Ponce A,Cataldo K,Meza D,Farías P,Estay C,Oyarzun-Ampuero F,Herrera-Molina R,Paula-Lima A,Ardiles ÁO,Hidalgo C,Adasme T,Muñoz P

更新日期：2020-06-26 00:00:00