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Hydrothermal Processing of Laminaria ochroleuca for the Production of Crude Extracts Used to Formulate Polymeric Nanoparticles.

Abstract：

:A green extraction process using only water was proposed for the simultaneous extraction of alginate and bioactive compounds from Laminaria ochroleuca. Operation was carried out during non-isothermal heating up to maximal temperatures over the range of 70 °C to 100 °C. Once separated, the alginate and the crude extract were characterised and the biological activities and cytotoxicity of the extracts was studied, the latter in intestinal epithelial cells. Those alginates obtained at 90 °C exhibited the highest extraction yields and viscoelastic features of the corresponding hydrogels. The obtained results show that the extracts obtained by non-isothermal extraction were suitable to formulate nanoparticles, which showed the smallest size (≈ 250-350 nm) when the higher content of fucoidan extract was present. Given the evidenced properties, the extracts may find an application in the formulation of nanoparticulate carriers for drug delivery.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Flórez-Fernández N,Álvarez-Viñas M,Guerreiro F,Torres MD,Grenha A,Domínguez H

doi

10.3390/md18070336

subject

Has Abstract

pub_date

2020-06-27 00:00:00

issue

7

issn

1660-3397

pii

md18070336

journal_volume

18

pub_type

杂志文章

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