Abstract：
:Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Bae M,Kim H,Shin Y,Kim BY,Lee SK,Oh KB,Shin J,Oh DCdoi
10.3390/md11082882subject
Has Abstractpub_date
2013-08-13 00:00:00pages
2882-93issue
8issn
1660-3397pii
md11082882journal_volume
11pub_type
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