Separacenes A-D, novel polyene polyols from the marine actinomycete, Streptomyces sp.

Abstract:

:Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar structure but possess different relative configurations, bear tetraene units flanked by two diol moieties, whereas the stereoisomeric separacenes C-D (3-4) possess a triene moiety between two diol substructures. Separacenes A-D each contain a terminal olefinic methylene. Separacene A displayed inhibitory activity against Candida albicans isocitrate lyase and weak cytotoxicity against both the colon carcinoma cell line HCT-116 and the lung cancer cell line A549.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Bae M,Kim H,Shin Y,Kim BY,Lee SK,Oh KB,Shin J,Oh DC

doi

10.3390/md11082882

subject

Has Abstract

pub_date

2013-08-13 00:00:00

pages

2882-93

issue

8

issn

1660-3397

pii

md11082882

journal_volume

11

pub_type

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