Abstract:
:Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany Edoi
10.3390/md16070218subject
Has Abstractpub_date
2018-06-25 00:00:00issue
7issn
1660-3397pii
md16070218journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::The marine environment is known as a rich source of chemical structures with numerous beneficial health effects. Among marine organisms, marine algae have been identified as an under-exploited plant resource, although they have long been recognized as valuable sources of structurally diverse bioactive compounds. Prese...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md9050803
更新日期:2011-01-01 00:00:00
abstract::One of the most distinctive and defining features of coleoid cephalopods-squid, cuttlefish and octopus-is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12052700
更新日期:2014-05-12 00:00:00
abstract::The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16090342
更新日期:2018-09-19 00:00:00
abstract::Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070418
更新日期:2019-07-19 00:00:00
abstract::To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17080440
更新日期:2019-07-26 00:00:00
abstract::N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md7040589
更新日期:2009-11-17 00:00:00
abstract::A new tetramic acid glycoside, aurantoside K, was isolated from a marine sponge belonging to the genus Melophlus. The structure of the compound was elucidated on the basis of spectroscopic analysis (¹H NMR, ¹H-¹H COSY, HSQC, and HMBC, as well as high-resolution ESILCMS). Aurantoside K did not show any significant acti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10010200
更新日期:2012-01-01 00:00:00
abstract::Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19020067
更新日期:2021-01-27 00:00:00
abstract::The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title:Marine drugs
pub_type: 杂志文章,已发布勘误
doi:10.3390/md15090292
更新日期:2017-09-20 00:00:00
abstract::The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12074231
更新日期:2014-07-23 00:00:00
abstract::The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18060327
更新日期:2020-06-23 00:00:00
abstract::Ulvan lyases can degrade ulvan to oligosaccharides with potent biological activity. A new ulvan lyase gene, ALT3695, was identified in Alteromonas sp. A321. Soluble expression of ALT3695 was achieved in Escherichia coli BL21 (DE3). The 1314-bp gene encoded a protein with 437 amino acid residues. The amino acid sequenc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100568
更新日期:2019-10-08 00:00:00
abstract::Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110441
更新日期:2018-11-09 00:00:00
abstract::TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12095072
更新日期:2014-09-25 00:00:00
abstract::Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md10061244
更新日期:2012-06-01 00:00:00
abstract::With the depletion of global fish stocks, caused by high demand and effective fishing techniques, alternative sources for long chain omega-3 fatty acids are required for human nutrition and aquaculture feeds. Recent research has focused on land-based cultivation of microalgae, the primary producers of omega-3 fatty ac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12063381
更新日期:2014-06-04 00:00:00
abstract::Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While ...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17030170
更新日期:2019-03-16 00:00:00
abstract::In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9081359
更新日期:2011-01-01 00:00:00
abstract::Cyclic imine toxins are neurotoxic, macrocyclic compounds produced by marine dinoflagellates. Mass spectrometric screenings of extracts from natural plankton assemblages revealed a high chemical diversity among this toxin class, yet only few toxins are structurally known. Here we report the structural characterization...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110446
更新日期:2018-11-14 00:00:00
abstract::Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030186
更新日期:2019-03-21 00:00:00
abstract::The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8122976
更新日期:2010-12-22 00:00:00
abstract::The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040104
更新日期:2018-03-26 00:00:00
abstract::Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8041106
更新日期:2010-04-01 00:00:00
abstract::High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18030148
更新日期:2020-03-04 00:00:00
abstract::Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15100317
更新日期:2017-10-17 00:00:00
abstract::The present study is focused on the intestinal absorption of sea cucumber saponins. We determined the pharmacokinetic characteristics and bioavailability of Echinoside A and Holotoxin A₁; the findings indicated that the bioavailability of Holotoxin A₁ was lower than Echinoside A. We inferred that the differences in ch...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14060114
更新日期:2016-06-17 00:00:00
abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031185
更新日期:2014-03-06 00:00:00
abstract::In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11041061
更新日期:2013-03-28 00:00:00
abstract::Astaxanthin (ASX) is a carotenoid pigment with strong antioxidant properties. We have reported previously that ASX protects neurons from the noxious effects of amyloid-β peptide oligomers, which promote excessive mitochondrial reactive oxygen species (mROS) production and induce a sustained increase in cytoplasmic Ca2...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18060335
更新日期:2020-06-26 00:00:00
abstract::The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18120613
更新日期:2020-12-02 00:00:00