The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.

Abstract:

:Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E

doi

10.3390/md16070218

subject

Has Abstract

pub_date

2018-06-25 00:00:00

issue

7

issn

1660-3397

pii

md16070218

journal_volume

16

pub_type

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