The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.


:Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and characterized its encapsulation efficiency and release profile. The proposed natural carriers increased the solubility and the bioavailability of curcumin. In addition, various physico-chemical properties of the developed soft nanocarriers with and without curcumin were studied. Nanoliposome-encapsulated curcumin increased the viability and network formation in the culture of primary cortical neurons and decreased the rate of apoptosis.


Mar Drugs


Marine drugs


Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E




Has Abstract


2018-06-25 00:00:00










  • Carrageenans as a new source of drugs with metal binding properties.

    abstract::Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Khotimchenko YS,Khozhaenko EV,Khotimchenko MY,Kolenchenko EA,Kovalev VV

    更新日期:2010-04-01 00:00:00

  • Two New Terpenoids from Talaromyces purpurogenus.

    abstract::A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang W,Wan X,Liu J,Wang J,Zhu H,Chen C,Zhang Y

    更新日期:2018-05-02 00:00:00

  • Azaspiracid shellfish poisoning: a review on the chemistry, ecology, and toxicology with an emphasis on human health impacts.

    abstract::Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Twiner MJ,Rehmann N,Hess P,Doucette GJ

    更新日期:2008-05-07 00:00:00

  • Isolation and Structure Elucidation of Cembranoids from a Dongsha Atoll Soft Coral Sarcophyton stellatum.

    abstract::Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were es...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ahmed AF,Chen YW,Huang CY,Tseng YJ,Lin CC,Dai CF,Wu YC,Sheu JH

    更新日期:2018-06-14 00:00:00

  • Discovery of new eunicellin-based diterpenoids from a Formosan soft coral Cladiella sp.

    abstract::A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chen TH,Lu MC,Chang YC,Su YD,Chen YH,Lin NC,Fang LS,Wu YC,Sung PJ

    更新日期:2013-11-14 00:00:00

  • Anti-Thrombin, Anti-Adhesive, Anti-Migratory, and Anti-Proliferative Activities of Sulfated Galactans from the Tropical Green Seaweed, Udotea flabellum.

    abstract::In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Mendes Marques ML,Presa FB,Viana RLS,Costa MSSP,Amorim MOR,Bellan DL,Alves MGCF,Costa LS,Trindade ES,Rocha HAO

    更新日期:2018-12-21 00:00:00

  • The Oxepane Motif in Marine Drugs.

    abstract::Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and sh...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Barbero H,Díez-Poza C,Barbero A

    更新日期:2017-11-15 00:00:00

  • Emerging concepts promising new horizons for marine biodiscovery and synthetic biology.

    abstract::The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Reen FJ,Gutiérrez-Barranquero JA,Dobson AD,Adams C,O'Gara F

    更新日期:2015-05-13 00:00:00

  • Marine Natural Products from the Yucatan Peninsula.

    abstract::Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Pech-Puch D,Pérez-Povedano M,Lenis-Rojas OA,Rodríguez J,Jiménez C

    更新日期:2020-01-16 00:00:00

  • Sphaeroane and neodolabellane diterpenes from the red alga Sphaerococcus coronopifolius.

    abstract::Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Smyrniotopoulos V,Vagias C,Roussis V

    更新日期:2009-05-19 00:00:00

  • Gliotoxin isolated from marine fungus Aspergillus sp. induces apoptosis of human cervical cancer and chondrosarcoma cells.

    abstract::Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nguyen VT,Lee JS,Qian ZJ,Li YX,Kim KN,Heo SJ,Jeon YJ,Park WS,Choi IW,Je JY,Jung WK

    更新日期:2013-12-24 00:00:00

  • Cytotoxicity of the ascidian Cystodytes dellechiajei against tumor cells and study of the involvement of associated microbiota in the production of cytotoxic compounds.

    abstract::Many cytotoxic compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Pyridoacridine alkaloids are the main compounds extracted from the ascidian Cystodytes dellechiajei. Here we describe the in vitro antiproliferative activity aga...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Martinez-García M,Diaz-Valdés M,Ramos-Esplá A,Salvador N,Lopez P,Larriba E,Antón J

    更新日期:2007-07-19 00:00:00

  • Chemical Diversity and Biological Activities of Marine Sponges of the Genus Suberea: A Systematic Review.

    abstract::Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: El-Demerdash A,Atanasov AG,Horbanczuk OK,Tammam MA,Abdel-Mogib M,Hooper JNA,Sekeroglu N,Al-Mourabit A,Kijjoa A

    更新日期:2019-02-12 00:00:00

  • Shrimp lipids: a source of cancer chemopreventive compounds.

    abstract::Shrimp is one of the most popular seafoods worldwide, and its lipids have been studied for biological activity in both, muscle and exoskeleton. Free fatty acids, triglycerides, carotenoids, and other lipids integrate this fraction, and some of these compounds have been reported with cancer chemopreventive activities. ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: López-Saiz CM,Suárez-Jiménez GM,Plascencia-Jatomea M,Burgos-Hernández A

    更新日期:2013-10-16 00:00:00

  • Fishery Wastes as a Yet Undiscovered Treasure from the Sea: Biomolecules Sources, Extraction Methods and Valorization.

    abstract::The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Caruso G,Floris R,Serangeli C,Di Paola L

    更新日期:2020-12-07 00:00:00

  • Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities.

    abstract::The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Ermolenko EV,Imbs AB,Gloriozova TA,Poroikov VV,Sikorskaya TV,Dembitsky VM

    更新日期:2020-12-02 00:00:00

  • New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509.

    abstract::A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Park JS,Kwon HC

    更新日期:2018-03-12 00:00:00

  • Chitosan Coated Microparticles Enhance Simvastatin Colon Targeting and Pro-Apoptotic Activity.

    abstract::This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h....

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Alhakamy NA,Fahmy UA,Ahmed OAA,Caruso G,Caraci F,Asfour HZ,Bakhrebah MA,N Alomary M,Abdulaal WH,Okbazghi SZ,Abdel-Naim AB,Eid BG,Aldawsari HM,Kurakula M,Mohamed AI

    更新日期:2020-04-24 00:00:00

  • Polysaccharide from Codium fragile Induces Anti-Cancer Immunity by Activating Natural Killer Cells.

    abstract::Natural polysaccharides exhibit beneficial immune modulatory effects, including immune stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, and its effect on tumor-bearing mice. Intravenous CFP treatment of C57BL/6 ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Park HB,Hwang J,Zhang W,Go S,Kim J,Choi I,You S,Jin JO

    更新日期:2020-12-08 00:00:00

  • Nine New Triterpene Glycosides, Magnumosides A₁-A₄, B₁, B₂, C₁, C₂ and C₄, from the Vietnamese Sea Cucumber Neothyonidium (=Massinium) magnum: Structures and Activities against Tumor Cells Independently and in Synergy with Radioactive Irradiation.

    abstract::Nine new sulfated triterpene glycosides, magnumosides A₁ (1), A₂ (2), A₃ (3), A₄ (4), B₁ (5), B₂ (6), C₁ (7), C₂ (8) and C₄ (9) as well as a known colochiroside B₂ (10) have been isolated from the tropical Indo-West Pacific sea cucumber Neothynidium (=Massinium) magnum (Phyllophoridae, Dendrochirotida) collected in th...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Silchenko AS,Kalinovsky AI,Avilov SA,Kalinin VI,Andrijaschenko PV,Dmitrenok PS,Chingizova EA,Ermakova SP,Malyarenko OS,Dautova TN

    更新日期:2017-08-16 00:00:00

  • New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism.

    abstract::The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

    更新日期:2018-11-16 00:00:00

  • Isolation of a new natural product and cytotoxic and antimicrobial activities of extracts from fungi of Indonesian marine habitats.

    abstract::In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Tarman K,Lindequist U,Wende K,Porzel A,Arnold N,Wessjohann LA

    更新日期:2011-02-25 00:00:00

  • A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).

    abstract::Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Huang Y,Peng C,Yi Y,Gao B,Shi Q

    更新日期:2017-07-18 00:00:00

  • Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity.

    abstract::Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chianese G,Scala F,Calcinai B,Cerrano C,Dien HA,Kaiser M,Tasdemir D,Taglialatela-Scafati O

    更新日期:2013-08-28 00:00:00

  • Novel Vibrio spp. Strains Producing Omega-3 Fatty Acids Isolated from Coastal Seawater.

    abstract::Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA) (20:5n-3) and docosahexaenoic acid (DHA) (22:6n-3), are considered essential for human health. Microorganisms are the primary producers of omega-3 fatty acids in marine ecosystems, representing a sustainable source of these ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Estupiñán M,Hernández I,Saitua E,Bilbao ME,Mendibil I,Ferrer J,Alonso-Sáez L

    更新日期:2020-02-01 00:00:00

  • Metabolomic Insights into Marine Phytoplankton Diversity.

    abstract::The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Marcellin-Gros R,Piganeau G,Stien D

    更新日期:2020-01-25 00:00:00

  • Development of pedigree classification using microsatellite and mitochondrial markers for Giant grouper broodstock (Epinephelus lanceolatus) management in Taiwan.

    abstract::Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kuo HC,Hsu HH,Chua CS,Wang TY,Chen YM,Chen TY

    更新日期:2014-04-30 00:00:00

  • A New Bioassay Platform Design for the Discovery of Small Molecules with Anticancer Immunotherapeutic Activity.

    abstract::Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

    更新日期:2020-11-29 00:00:00

  • Posidonia oceanica (L.) Delile Ethanolic Extract Modulates Cell Activities with Skin Health Applications.

    abstract::Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Cornara L,Pastorino G,Borghesi B,Salis A,Clericuzio M,Marchetti C,Damonte G,Burlando B

    更新日期:2018-01-10 00:00:00

  • In situ detection of antibiotic amphotericin B produced in Streptomyces nodosus using Raman microspectroscopy.

    abstract::The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Miyaoka R,Hosokawa M,Ando M,Mori T,Hamaguchi HO,Takeyama H

    更新日期:2014-05-13 00:00:00