Abstract：
:The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclude the possibility that these particles might be crystalline structures, as often believed, by showing that they are, instead, organic-inorganic hybrids, each comprising a filamentous organic component (the crystal ghost) made up of acidic proteins. The hypothesis is suggested that the crystal ghosts bind and stabilize amorphous calcium phosphate and that their subsequent degradation allows the calcium phosphate, once released, to acquire a hydroxyapatite, crystal-like organization. A conclusive view of the mechanism of biological calcification cannot yet be proposed; even so, however, the role of crystal ghosts as a template of the structures usually called "crystallites" is a concept that has gathered increasing support and can no longer be disregarded.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Bonucci Edoi
10.3390/md12074231subject
Has Abstractpub_date
2014-07-23 00:00:00pages
4231-46issue
7issn
1660-3397pii
md12074231journal_volume
12pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18090465
更新日期：2020-09-14 00:00:00
abstract：:The development and use of topical microbicides potentially offers an additional strategy to reduce the spread of the Human Immunodeficiency Virus (HIV). Carbohydrate-binding agents (CBAs) that show specificity for high mannose carbohydrates on the surface of the heavily glycosylated envelope of HIV are endowed with p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10071476
更新日期：2012-07-01 00:00:00
abstract：:In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA-ALG-Cu2+) composite f...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18120660
更新日期：2020-12-21 00:00:00
abstract：:High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030148
更新日期：2020-03-04 00:00:00
abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100564
更新日期：2019-09-30 00:00:00
abstract：:Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11124788
更新日期：2013-12-02 00:00:00
abstract：:Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060331
更新日期：2019-06-03 00:00:00
abstract：:Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13020838
更新日期：2015-02-04 00:00:00
abstract：:Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the pH dependence of an...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110614
更新日期：2019-10-29 00:00:00
abstract：:Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12073970
更新日期：2014-06-30 00:00:00
abstract：:Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17030170
更新日期：2019-03-16 00:00:00
abstract：:Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110631
更新日期：2019-11-06 00:00:00
abstract：:Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18040228
更新日期：2020-04-24 00:00:00
abstract：:The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8122976
更新日期：2010-12-22 00:00:00
abstract：:Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120369
更新日期：2017-12-01 00:00:00
abstract：:N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7040589
更新日期：2009-11-17 00:00:00
abstract：:The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12042164
更新日期：2014-04-10 00:00:00
abstract：:Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17080458
更新日期：2019-08-05 00:00:00
abstract：:Many marine bacteria produce exopolysaccharides (EPS) as a strategy for growth, adhering to solid surfaces, and to survive adverse conditions. There is growing interest in isolating new EPS producing bacteria from marine environments, particularly from extreme marine environments such as deep-sea hydrothermal vents ch...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8061779
更新日期：2010-06-03 00:00:00
abstract：:The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, w...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110438
更新日期：2018-11-08 00:00:00
abstract：:Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8082318
更新日期：2010-08-11 00:00:00
abstract：:Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12041773
更新日期：2014-03-27 00:00:00
abstract：:Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12041876
更新日期：2014-03-28 00:00:00
abstract：:Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070130
更新日期：2016-07-08 00:00:00
abstract：:Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12084539
更新日期：2014-08-19 00:00:00
abstract：:Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030187
更新日期：2019-03-22 00:00:00
abstract：:Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13127064
更新日期：2015-12-05 00:00:00
abstract：:Sulphated polysaccharides with anti-thrombotic and anti-coagulant activities have been found in various marine biota. In this study, a previously characterised anti-thrombotic and anti-coagulant extract from blacklip abalone was fractionated by anion exchange chromatography (AEC), pooled (on a sulphated polysaccharide...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15080240
更新日期：2017-08-04 00:00:00
abstract：:Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100368
更新日期：2018-10-05 00:00:00
abstract：:In this study, as part of our continuous search for environmentally-friendly antifoulants from natural resources, subergorgic acid (SA) was identified from the gorgonian coral Subergorgia suberosa, demonstrating non-toxic, significant inhibitory effects (EC50 1.25 μg/mL, LC50 > 25 μg/mL) against the settlement of Bala...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020101
更新日期：2019-02-06 00:00:00
