Biotechnological Production of Docosahexaenoic Acid Using Aurantiochytrium limacinum: Carbon Sources Comparison And Growth Characterization.

Abstract:

:Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic parameters corresponding to each carbon source. Artificial Marine Medium (AMM) with glucose, pure and crude glycerol offered similar biomass yields. The net growth rates (0.10-0.12 h(-1)), biomass (0.7-0.8 g cells/g Substrate) and product (0.14-0.15 g DHA/g cells) yields, as well as DHA productivity were similar using the three carbon sources. Viable potential applications to valorize crude glycerol are envisioned to avoid an environmental problem due to the excess of byproduct.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Abad S,Turon X

doi

10.3390/md13127064

subject

Has Abstract

pub_date

2015-12-05 00:00:00

pages

7275-84

issue

12

issn

1660-3397

pii

md13127064

journal_volume

13

pub_type

杂志文章
  • New Monoterpenoids and Polyketides from the Deep-Sea Sediment-Derived Fungus Aspergillus sydowii MCCC 3A00324.

    abstract::Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18110561

    authors: Niu S,Yang L,Chen T,Hong B,Pei S,Shao Z,Zhang G

    更新日期:2020-11-17 00:00:00

  • Structure of fucoidan from brown seaweed Turbinaria ornata as studied by electrospray ionization mass spectrometry (ESIMS) and small angle X-ray scattering (SAXS) techniques.

    abstract::The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11072431

    authors: Thanh TT,Tran VT,Yuguchi Y,Bui LM,Nguyen TT

    更新日期:2013-07-12 00:00:00

  • Kalkitoxin inhibits angiogenesis, disrupts cellular hypoxic signaling, and blocks mitochondrial electron transport in tumor cells.

    abstract::The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13031552

    authors: Morgan JB,Liu Y,Coothankandaswamy V,Mahdi F,Jekabsons MB,Gerwick WH,Valeriote FA,Zhou YD,Nagle DG

    更新日期:2015-03-20 00:00:00

  • Bioactive compounds from the Red Sea marine sponge Hyrtios species.

    abstract::In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11041061

    authors: Youssef DT,Shaala LA,Asfour HZ

    更新日期:2013-03-28 00:00:00

  • Cloning of the Bisucaberin B Biosynthetic Gene Cluster from the Marine Bacterium Tenacibaculum mesophilum, and Heterologous Production of Bisucaberin B.

    abstract::The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16090342

    authors: Fujita MJ,Goto Y,Sakai R

    更新日期:2018-09-19 00:00:00

  • New Cyclotetrapeptides and a New Diketopiperzine Derivative from the Marine Sponge-Associated Fungus Neosartorya glabra KUFA 0702.

    abstract::Two new cyclotetrapeptides, sartoryglabramides A (5) and B (6), and a new analog of fellutanine A (8) were isolated, together with six known compounds including ergosta-4, 6, 8 (14), 22-tetraen-3-one, ergosterol 5, 8-endoperoxide, helvolic acid, aszonalenin (1), (3R)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodia...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md14070136

    authors: May Zin WW,Buttachon S,Dethoup T,Fernandes C,Cravo S,Pinto MM,Gales L,Pereira JA,Silva AM,Sekeroglu N,Kijjoa A

    更新日期:2016-07-20 00:00:00

  • Clinical trial: marine lipid suppositories as laxatives.

    abstract:UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...

    journal_title:Marine drugs

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3390/md10092047

    authors: Ormarsson OT,Geirsson T,Bjornsson ES,Jonsson T,Moller P,Loftsson T,Stefansson E

    更新日期:2012-09-01 00:00:00

  • Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities.

    abstract::The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md18120613

    authors: Ermolenko EV,Imbs AB,Gloriozova TA,Poroikov VV,Sikorskaya TV,Dembitsky VM

    更新日期:2020-12-02 00:00:00

  • Cephalopods as vectors of harmful algal bloom toxins in marine food webs.

    abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md11093381

    authors: Lopes VM,Lopes AR,Costa P,Rosa R

    更新日期:2013-09-06 00:00:00

  • Cucumarioside A₂-2 Causes Macrophage Activation in Mouse Spleen.

    abstract::The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15110341

    authors: Pislyagin EA,Manzhulo IV,Gorpenchenko TY,Dmitrenok PS,Avilov SA,Silchenko AS,Wang YM,Aminin DL

    更新日期:2017-11-01 00:00:00

  • Possibilities of Fucoidan Utilization in the Development of Pharmaceutical Dosage Forms.

    abstract::Fucoidan is a polysaccharide built from L-fucose molecules. The main source of this polysaccharide is the extracellular matrix of brown seaweed (Phaeophyta), but it can be also isolated from invertebrates such as sea urchins (Echinoidea) and sea cucumbers (Holothuroidea). Interest in fucoidan is related to its broad b...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md17080458

    authors: Citkowska A,Szekalska M,Winnicka K

    更新日期:2019-08-05 00:00:00

  • Emerging concepts promising new horizons for marine biodiscovery and synthetic biology.

    abstract::The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md13052924

    authors: Reen FJ,Gutiérrez-Barranquero JA,Dobson AD,Adams C,O'Gara F

    更新日期:2015-05-13 00:00:00

  • Characterization of Properties and Transglycosylation Abilities of Recombinant α-Galactosidase from Cold-Adapted Marine Bacterium Pseudoalteromonas KMM 701 and Its C494N and D451A Mutants.

    abstract::A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16100349

    authors: Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

    更新日期:2018-09-24 00:00:00

  • Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans.

    abstract::Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic ana...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15060177

    authors: Ragini K,Piggott AM,Karuso P

    更新日期:2017-06-15 00:00:00

  • New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens.

    abstract::A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambi...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17020100

    authors: Ebada SS,Müller WEG,Lin W,Proksch P

    更新日期:2019-02-06 00:00:00

  • Functional Characterization and Evolutionary Analysis of Glycine-Betaine Biosynthesis Pathway in Red Seaweed Pyropia yezoensis.

    abstract::The red seaweed Pyropia yezoensis is an ideal research model for dissecting the molecular mechanisms underlying its robust acclimation to abiotic stresses in intertidal zones. Glycine betaine (GB) was an important osmolyte in maintaining osmotic balance and stabilizing the quaternary structure of complex proteins unde...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17010070

    authors: Mao Y,Chen N,Cao M,Chen R,Guan X,Wang D

    更新日期:2019-01-21 00:00:00

  • Induction of Natural Defenses in Tomato Seedlings by Using Alginate and Oligoalginates Derivatives Extracted from Moroccan Brown Algae.

    abstract::Polysaccharides extracted from marine algae have attracted much attention due to their biotechnological applications, including therapeutics, cosmetics, and mainly in agriculture and horticulture as biostimulants, biofertilizers, and stimulators of the natural defenses of plants. This study aimed to evaluate the abili...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18100521

    authors: Aitouguinane M,Bouissil S,Mouhoub A,Rchid H,Fendri I,Abdelkafi S,Ould El-Hadj MD,Boual Z,Dubessay P,Gardarin C,Michaud P,El Alaoui-Talibi Z,El Modafar C,Pierre G,Delattre C

    更新日期:2020-10-19 00:00:00

  • Aeroplysinin-1, a Sponge-Derived Multi-Targeted Bioactive Marine Drug.

    abstract::Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md14010001

    authors: García-Vilas JA,Martínez-Poveda B,Quesada AR,Medina MÁ

    更新日期:2015-12-22 00:00:00

  • New Hydroquinone Monoterpenoid and Cembranoid-Related Metabolites from the Soft Coral Sarcophyton tenuispiculatum.

    abstract::Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md19010008

    authors: Huang TY,Huang CY,Chen SR,Weng JR,Tu TH,Cheng YB,Wu SH,Sheu JH

    更新日期:2020-12-27 00:00:00

  • Marine and semi-synthetic hydroxysteroids as new scaffolds for pregnane X receptor modulation.

    abstract::In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12063091

    authors: Sepe V,Di Leva FS,D'Amore C,Festa C,De Marino S,Renga B,D'Auria MV,Novellino E,Limongelli V,D'Souza L,Majik M,Zampella A,Fiorucci S

    更新日期:2014-05-27 00:00:00

  • Potential anti-HPV and related cancer agents from marine resources: an overview.

    abstract::Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md12042019

    authors: Wang SX,Zhang XS,Guan HS,Wang W

    更新日期:2014-04-03 00:00:00

  • New Naphthoquinone Terpenoids from Marine Actinobacterium, Streptomyces sp. CNQ-509.

    abstract::A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16030090

    authors: Park JS,Kwon HC

    更新日期:2018-03-12 00:00:00

  • Peridinin from the marine symbiotic dinoflagellate, Symbiodinium sp., regulates eosinophilia in mice.

    abstract::Peridinin and fucoxanthin, which are natural carotenoids isolated from a symbiotic dinoflagellate, Symbiodinium sp., and a brown alga, Petalonia fascia, respectively, were compared for inhibitory effects on delayed-type hypersensitivity in mice. The number of eosinophils at the site of inflammation and in peripheral b...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12041773

    authors: Onodera K,Konishi Y,Taguchi T,Kiyoto S,Tominaga A

    更新日期:2014-03-27 00:00:00

  • Sphaeroane and neodolabellane diterpenes from the red alga Sphaerococcus coronopifolius.

    abstract::Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md7020184

    authors: Smyrniotopoulos V,Vagias C,Roussis V

    更新日期:2009-05-19 00:00:00

  • Design, synthesis and evaluation of new marine alkaloid-derived pentacyclic structures with anti-tumoral potency.

    abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13010655

    authors: Boucle S,Melin C,Clastre M,Guillard J

    更新日期:2015-01-19 00:00:00

  • The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning.

    abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15070219

    authors: Rhodes LL,Smith KF,Murray S,Harwood DT,Trnski T,Munday R

    更新日期:2017-07-11 00:00:00

  • Antiproliferative Activity of Glycosaminoglycan-Like Polysaccharides Derived from Marine Molluscs.

    abstract::Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16020063

    authors: Aldairi AF,Ogundipe OD,Pye DA

    更新日期:2018-02-15 00:00:00

  • Plakinamine P, A Steroidal Alkaloid with Bactericidal Activity against Mycobacterium tuberculosis.

    abstract::Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17120707

    authors: Rodrigues Felix C,Roberts JC,Winder PL,Gupta R,Diaz MC,Pomponi SA,Wright AE,Rohde KH

    更新日期:2019-12-16 00:00:00

  • Cephalopod ink: production, chemistry, functions and applications.

    abstract::One of the most distinctive and defining features of coleoid cephalopods-squid, cuttlefish and octopus-is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalo...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md12052700

    authors: Derby CD

    更新日期:2014-05-12 00:00:00

  • Diphlorethohydroxycarmalol Attenuates Fine Particulate Matter-Induced Subcellular Skin Dysfunction.

    abstract::The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17020095

    authors: Zhen AX,Piao MJ,Hyun YJ,Kang KA,Madushan Fernando PDS,Cho SJ,Ahn MJ,Hyun JW

    更新日期:2019-02-01 00:00:00