Crellasterones A and B: A-Norsterol Derivatives from the New Caledonian Sponge Crella incrustans.

Abstract:

:Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic analysis and revealed unprecedented marine natural products with a ring-contracted A-norsterone nucleus and 2-hydroxycyclopentenone chromophore. The absolute configurations were derived from electronic circular dichroism (ECD) measurements in conjunction with high-level density functional theory (DFT) calculations.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Ragini K,Piggott AM,Karuso P

doi

10.3390/md15060177

subject

Has Abstract

pub_date

2017-06-15 00:00:00

issue

6

issn

1660-3397

pii

md15060177

journal_volume

15

pub_type

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