Abstract:
:Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8-24 μM.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Zhao M,Cheng S,Yuan W,Xi Y,Li X,Dong J,Huang K,Gustafson KR,Yan Pdoi
10.3390/md14060111subject
Has Abstractpub_date
2016-06-03 00:00:00issue
6issn
1660-3397pii
md14060111journal_volume
14pub_type
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