Cembranoids from a Chinese Collection of the Soft Coral Lobophytum crassum.

Abstract:

:Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compounds were determined by extensive spectroscopic analysis and by comparison with previously reported data. Locrassumin C (3) possesses an unprecedented tetradecahydrobenzo[3,4]cyclobuta[1,2][8]annulene ring system. Compounds 1, 7, 12, 13, and 17 exhibited moderate inhibition against lipopolysaccharide (LPS)-induced nitric oxide (NO) production with IC50 values of 8-24 μM.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Zhao M,Cheng S,Yuan W,Xi Y,Li X,Dong J,Huang K,Gustafson KR,Yan P

doi

10.3390/md14060111

subject

Has Abstract

pub_date

2016-06-03 00:00:00

issue

6

issn

1660-3397

pii

md14060111

journal_volume

14

pub_type

杂志文章
  • Bacterial Long-Chain Polyunsaturated Fatty Acids: Their Biosynthetic Genes, Functions, and Practical Use.

    abstract::The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md14050094

    authors: Yoshida K,Hashimoto M,Hori R,Adachi T,Okuyama H,Orikasa Y,Nagamine T,Shimizu S,Ueno A,Morita N

    更新日期:2016-05-12 00:00:00

  • New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques.

    abstract::Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that functions as a master regulator of cellular growth and metabolism, in response to nutrient and hormonal stimuli. mTOR functions in two distinct complexes-mTORC1 is sensitive to rapamycin, while, mTORC2 is insensitive to this dr...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16100385

    authors: Ruiz-Torres V,Losada-Echeberría M,Herranz-López M,Barrajón-Catalán E,Galiano V,Micol V,Encinar JA

    更新日期:2018-10-15 00:00:00

  • Bioactive peptides and depsipeptides with anticancer potential: sources from marine animals.

    abstract::Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabo...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md10050963

    authors: Suarez-Jimenez GM,Burgos-Hernandez A,Ezquerra-Brauer JM

    更新日期:2012-05-01 00:00:00

  • The antihyperlipidemic mechanism of high sulfate content ulvan in rats.

    abstract::Numerous studies have suggested that hyperlipidemia is closely linked to cardiovascular disease. The aim of this study was to investigate the possible antihyperlipidemia mechanism of HU (high sulfate content of ulvan) in high-cholesterol fed rats. Wistar rats were made hyperlipidemic by feeding with a high-cholesterol...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13063407

    authors: Qi H,Sheng J

    更新日期:2015-05-29 00:00:00

  • Borrelidins C-E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp.

    abstract::Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15060166

    authors: Kim J,Shin D,Kim SH,Park W,Shin Y,Kim WK,Lee SK,Oh KB,Shin J,Oh DC

    更新日期:2017-06-06 00:00:00

  • In vitro acylation of okadaic acid in the presence of various bivalves' extracts.

    abstract::The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11020300

    authors: Konoki K,Onoda T,Watanabe R,Cho Y,Kaga S,Suzuki T,Yotsu-Yamashita M

    更新日期:2013-01-29 00:00:00

  • Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems.

    abstract::Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysac...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md8041305

    authors: Hamman JH

    更新日期:2010-04-19 00:00:00

  • Inhibitory effects of Ecklonia cava extract on high glucose-induced hepatic stellate cell activation.

    abstract::Nonalcoholic steatohepatitis (NASH) is a disease closely associated with obesity and diabetes. A prevalence of type 2 diabetes and a high body mass index in cryptogenic cirrhosis may imply that obesity leads to cirrhosis. Here, we examined the effects of an extract of Ecklonia cava, a brown algae, on the activation of...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md9122793

    authors: Yokogawa K,Matsui-Yuasa I,Tamura A,Terada M,Kojima-Yuasa A

    更新日期:2011-12-01 00:00:00

  • Citrinin Monomer and Dimer Derivatives with Antibacterial and Cytotoxic Activities Isolated from the Deep Sea-Derived Fungus Penicillium citrinum NLG-S01-P1.

    abstract::Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their struct...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17010046

    authors: Wang W,Liao Y,Zhang B,Gao M,Ke W,Li F,Shao Z

    更新日期:2019-01-10 00:00:00

  • Co-processed chitin-mannitol as a new excipient for Oro-dispersible tablets.

    abstract::This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13041739

    authors: Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

    更新日期:2015-03-30 00:00:00

  • The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.

    abstract::Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16070218

    authors: Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E

    更新日期:2018-06-25 00:00:00

  • Potential anti-HPV and related cancer agents from marine resources: an overview.

    abstract::Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md12042019

    authors: Wang SX,Zhang XS,Guan HS,Wang W

    更新日期:2014-04-03 00:00:00

  • Anti-Hepatocellular Carcinoma (HepG2) Activities of Monoterpene Hydroxy Lactones Isolated from the Marine Microalga Tisochrysis Lutea.

    abstract::Tisochrysis lutea is a marine haptophyte rich in omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA)) and carotenoids (e.g., fucoxanthin). Because of the nutraceutical applications of these compounds, this microalga is being used in aquaculture to feed oyster and shrimp larvae. In our earlier report,...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18110567

    authors: Gangadhar KN,Rodrigues MJ,Pereira H,Gaspar H,Malcata FX,Barreira L,Varela J

    更新日期:2020-11-19 00:00:00

  • Antiviral lead compounds from marine sponges.

    abstract::Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md8102619

    authors: Sagar S,Kaur M,Minneman KP

    更新日期:2010-10-11 00:00:00

  • The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning.

    abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15070219

    authors: Rhodes LL,Smith KF,Murray S,Harwood DT,Trnski T,Munday R

    更新日期:2017-07-11 00:00:00

  • Sphaeroane and neodolabellane diterpenes from the red alga Sphaerococcus coronopifolius.

    abstract::Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md7020184

    authors: Smyrniotopoulos V,Vagias C,Roussis V

    更新日期:2009-05-19 00:00:00

  • Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant Myoporum bontioides A. Gray.

    abstract::The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, w...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16110438

    authors: Dong LM,Huang LL,Dai H,Xu QL,Ouyang JK,Jia XC,Gu WX,Tan JW

    更新日期:2018-11-08 00:00:00

  • Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach.

    abstract::A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17100577

    authors: Shikov AN,Pozharitskaya ON,Faustova NM,Kosman VM,Makarov VG,Razzazi-Fazeli E,Novak J

    更新日期:2019-10-11 00:00:00

  • Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

    abstract::Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13053103

    authors: Phan CS,Ng SY,Kim EA,Jeon YJ,Palaniveloo K,Vairappan CS

    更新日期:2015-05-19 00:00:00

  • The Inhibitory Effect of Protamine on Platelets is Attenuated by Heparin without Inducing Thrombocytopenia in Rodents.

    abstract::Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17090539

    authors: Miklosz J,Kalaska B,Kaminski K,Rusak M,Szczubialka K,Nowakowska M,Pawlak D,Mogielnicki A

    更新日期:2019-09-17 00:00:00

  • Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.

    abstract::Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md15060165

    authors: Miller IJ,Chevrette MG,Kwan JC

    更新日期:2017-06-06 00:00:00

  • Specific Metabolites in a Phaeodactylum tricornutum Strain Isolated from Western Norwegian Fjord Water.

    abstract::We have searched for special characteristics in growth, protein expression, fatty acids and volatile organic compounds (VOCs) in a local Phaeodactylum tricornutum Bohlin strain (Bergen Marine Biobank), by comparing it with a common accession strain (CCAP). Differences in growth and expressed proteins were detected bet...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md14010009

    authors: Prestegard SK,Erga SR,Steinrücken P,Mjøs SA,Knutsen G,Rohloff J

    更新日期:2015-12-30 00:00:00

  • Mannose-Specific Lectins from Marine Algae: Diverse Structural Scaffolds Associated to Common Virucidal and Anti-Cancer Properties.

    abstract::To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. De...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md17080440

    authors: Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé P

    更新日期:2019-07-26 00:00:00

  • Marine Bacteria, A Source for Alginolytic Enzyme to Disrupt Pseudomonas aeruginosa Biofilms.

    abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17050307

    authors: Daboor SM,Raudonis R,Cohen A,Rohde JR,Cheng Z

    更新日期:2019-05-24 00:00:00

  • Haliotis discus discus Sialic Acid-Binding Lectin Reduces the Oncolytic Vaccinia Virus Induced Toxicity in a Glioblastoma Mouse Model.

    abstract::Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, o...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16050141

    authors: Li G,Mei S,Cheng J,Wu T,Luo J

    更新日期:2018-04-26 00:00:00

  • Ceramide as a Target of Marine Triterpene Glycosides for Treatment of Human Myeloid Leukemia.

    abstract::Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low t...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md14110205

    authors: Yun SH,Shin SW,Stonik VA,Park JI

    更新日期:2016-11-03 00:00:00

  • Production of bioactive secondary metabolites by marine vibrionaceae.

    abstract::Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md9091440

    authors: Mansson M,Gram L,Larsen TO

    更新日期:2011-01-01 00:00:00

  • Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.

    abstract::Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md14070130

    authors: Elhady SS,Al-Abd AM,El-Halawany AM,Alahdal AM,Hassanean HA,Ahmed SA

    更新日期:2016-07-08 00:00:00

  • Induction of apoptosis, G₀/G₁ phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus.

    abstract::Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md10112596

    authors: Liu M,Zhao X,Zhao J,Xiao L,Liu H,Wang C,Cheng L,Wu N,Lin X

    更新日期:2012-11-21 00:00:00

  • Polysaccharide from Codium fragile Induces Anti-Cancer Immunity by Activating Natural Killer Cells.

    abstract::Natural polysaccharides exhibit beneficial immune modulatory effects, including immune stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, and its effect on tumor-bearing mice. Intravenous CFP treatment of C57BL/6 ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18120626

    authors: Park HB,Hwang J,Zhang W,Go S,Kim J,Choi I,You S,Jin JO

    更新日期:2020-12-08 00:00:00