The effect of cholesterol on the long-range network of interactions established among sea anemone Sticholysin II residues at the water-membrane interface.

abstract：:In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), longamide B (8) and longamide A (9), the dimeric oroidin derivatives sceptrin (10)...

journal_title：Marine drugs

authors： Scala F,Fattorusso E,Menna M,Taglialatela-Scafati O,Tierney M,Kaiser M,Tasdemir D

更新日期：2010-07-14 00:00:00

abstract：:Sea cucumbers belonging to echinoderm are traditionally used as tonic food in China and other Asian countries. They produce abundant biologically active triterpene glycosides. More than 300 triterpene glycosides have been isolated and characterized from various species of sea cucumbers, which are classified as holosta...

journal_title：Marine drugs

authors： Mondol MAM,Shin HJ,Rahman MA,Islam MT

更新日期：2017-10-17 00:00:00

abstract：:Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divid...

journal_title：Marine drugs

authors： Li D,Li L,Xu T,Wang T,Ren J,Liu X,Li Y

更新日期：2018-01-08 00:00:00

abstract：:Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...

journal_title：Marine drugs

authors： Schwartz BD,Coster MJ,Skinner-Adams TS,Andrews KT,White JM,Davis RA

更新日期：2015-09-15 00:00:00

abstract：:Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...

journal_title：Marine drugs

authors： Ding L,Ren L,Li S,Song J,Han Z,He S,Xu S

更新日期：2019-06-10 00:00:00

abstract：:Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...

journal_title：Marine drugs

authors： Righini H,Baraldi E,García Fernández Y,Martel Quintana A,Roberti R

更新日期：2019-05-20 00:00:00

abstract：:Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...

journal_title：Marine drugs

authors： Huang Y,Peng C,Yi Y,Gao B,Shi Q

更新日期：2017-07-18 00:00:00

abstract：:The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule ...

journal_title：Marine drugs

authors： Morgan JB,Liu Y,Coothankandaswamy V,Mahdi F,Jekabsons MB,Gerwick WH,Valeriote FA,Zhou YD,Nagle DG

更新日期：2015-03-20 00:00:00

abstract：:A series of novel cyclic marinopyrroles were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-x(L), was evaluated using ELISA assays. Both atropisomers of marinopyrrole A (1) show similar potency. A tetrabromo congener 9 is t...

journal_title：Marine drugs

authors： Cheng C,Liu Y,Balasis ME,Simmons NL,Li J,Song H,Pan L,Qin Y,Nicolaou KC,Sebti SM,Li R

更新日期：2014-03-07 00:00:00

abstract：:Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...

journal_title：Marine drugs

authors： Kellogg J,Grace MH,Lila MA

更新日期：2014-10-22 00:00:00

abstract：:Prostate cancer (PCa), the most common malignancy in men, is a major cause of cancer deaths. A better understanding of the mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment of this patient group. As a dietary carotenoid, astaxanthin has been demonstrated to exe...

journal_title：Marine drugs

authors： Ni X,Yu H,Wang S,Zhang C,Shen S

更新日期：2017-03-08 00:00:00

abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...

journal_title：Marine drugs

authors： Liang F,Li C,Hou T,Wen C,Kong S,Ma D,Sun C,Li S

更新日期：2020-08-10 00:00:00

abstract：:Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fr...

journal_title：Marine drugs

authors： Bonnard I,Jhaumeer-Laulloo SB,Bontemps N,Banaigs B,Aknin M

更新日期：2010-02-23 00:00:00

abstract：:Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae as a great source o...

journal_title：Marine drugs

authors： Genovese G,Tedone L,Hamann MT,Morabito M

更新日期：2009-08-11 00:00:00

abstract：:Nosocomial infections and increasing multi-drug resistance caused by Acinetobacter baumannii have been recognized as emerging problems worldwide. Moreover, A. baumannii is able to colonize various abiotic materials and medical devices, making it difficult to eradicate and leading to ventilator-associated pneumonia, an...

journal_title：Marine drugs

authors： Tseng SP,Hung WC,Huang CY,Lin YS,Chan MY,Lu PL,Lin L,Sheu JH

更新日期：2016-07-29 00:00:00

abstract：:Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar...

journal_title：Marine drugs

authors： Bae M,Kim H,Shin Y,Kim BY,Lee SK,Oh KB,Shin J,Oh DC

更新日期：2013-08-13 00:00:00

abstract：:Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P.stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus co...

journal_title：Marine drugs

authors： Wu S,Zheng R,Sha Z,Sun C

更新日期：2017-07-10 00:00:00

abstract：:Green seaweeds are rich sources of sulfated polysaccharides (SPs) with potential biomedical and nutraceutical applications. The aim of this work was to evaluate the immunostimulatory activity of SPs from the seaweed, Caulerpa cupressoides var. flabellata on murine RAW 264.7 macrophages. SPs were evaluated for their ab...

journal_title：Marine drugs

authors： Barbosa JDS,Costa MSSP,Melo LFM,Medeiros MJC,Pontes DL,Scortecci KC,Rocha HAO

更新日期：2019-02-09 00:00:00

abstract：:Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans. It is also an excitatory amino acid analog to glutamate and kainic acid which acts through glutamate receptors eliciting a very rapid and potent neurotoxic respo...

journal_title：Marine drugs

authors： Gill SS,Hou Y,Ghane T,Pulido OM

更新日期：2008-02-14 00:00:00

abstract：:Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...

journal_title：Marine drugs

authors： Daboor SM,Raudonis R,Cohen A,Rohde JR,Cheng Z

更新日期：2019-05-24 00:00:00

abstract：:Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...

journal_title：Marine drugs

authors： Nicosia A,Maggio T,Mazzola S,Cuttitta A

更新日期：2013-10-30 00:00:00

abstract：:An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...

journal_title：Marine drugs

authors： Lee HP,Huang SY,Lin YY,Wang HM,Jean YH,Wu SF,Duh CY,Wen ZH

更新日期：2013-01-10 00:00:00

abstract：:Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...

journal_title：Marine drugs

authors： Oh JH,Choi JS,Nam TJ

更新日期：2018-10-05 00:00:00

abstract：:The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been a...

journal_title：Marine drugs

authors： Ilievska B,Loftsson T,Hjalmarsdottir MA,Asgrimsdottir GM

更新日期：2016-06-01 00:00:00

abstract：:The marine environment is known as a rich source of chemical structures with numerous beneficial health effects. Among marine organisms, marine algae have been identified as an under-exploited plant resource, although they have long been recognized as valuable sources of structurally diverse bioactive compounds. Prese...

journal_title：Marine drugs

authors： Pangestuti R,Kim SK

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Evaluation of the potential efficacy and safety of combination therapies for advanced soft tissue sarcomas (STS) has increased substantially after approval of trabectedin and pazopanib. Trabectedin's introduction in Europe in 2007 depended mainly on its activity in so-called L-sarcomas (liposarcoma and leiom...

journal_title：Marine drugs

authors： Kasper B,Reichardt P,Pink D,Sommer M,Mathew M,Rauch G,Hohenberger P

更新日期：2015-01-13 00:00:00

abstract：:The purpose of this study is to elucidate both the chemical and conformational structure of an unfractionated fucoidan extracted from brown seaweed Turbinaria ornata collected at Nha-trang bay, Vietnam. Electrospray ionization mass spectrometry (ESI-MS) was used for determining the chemical structure and small angle X...

journal_title：Marine drugs

authors： Thanh TT,Tran VT,Yuguchi Y,Bui LM,Nguyen TT

更新日期：2013-07-12 00:00:00

abstract：:The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...

journal_title：Marine drugs

authors： Gabbia D,Saponaro M,Sarcognato S,Guido M,Ferri N,Carrara M,De Martin S

更新日期：2020-01-17 00:00:00

abstract：:The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug...

journal_title：Marine drugs

authors： Notario-Pérez F,Martín-Illana A,Cazorla-Luna R,Ruiz-Caro R,Bedoya LM,Tamayo A,Rubio J,Veiga MD

更新日期：2017-02-21 00:00:00

abstract：:After in situ incubation at the site for a year, phytoplanktons in surface water were exposed to natural light in temperate lakes (every month); thereafter, the net production rate of photoprotective compounds (mycosporine-like amino acids, MAAs) was calculated using (13)C labeled tracer. This is the first report desc...

journal_title：Marine drugs

authors： Ha SY,Lee Y,Kim MS,Kumar KS,Shin KH

更新日期：2015-11-06 00:00:00