Abstract:
:The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule neurons. Subsequent studies revealed that kalkitoxin generated a delayed form of colon tumor cell cytotoxicity in 7-day clonogenic cell survival assays. Cell line- and exposure time-dependent cytostatic/cytotoxic effects were previously observed with mitochondria-targeted inhibitors of hypoxia-inducible factor-1 (HIF-1). The transcription factor HIF-1 functions as a key regulator of oxygen homeostasis. Therefore, we investigated the ability of kalkitoxin to inhibit hypoxic signaling in human tumor cell lines. Kalkitoxin potently and selectively inhibited hypoxia-induced activation of HIF-1 in T47D breast tumor cells (IC50 5.6 nM). Mechanistic studies revealed that kalkitoxin inhibits HIF-1 activation by suppressing mitochondrial oxygen consumption at electron transport chain (ETC) complex I (NADH-ubiquinone oxidoreductase). Further studies indicate that kalkitoxin targets tumor angiogenesis by blocking the induction of angiogenic factors (i.e., VEGF) in tumor cells.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Morgan JB,Liu Y,Coothankandaswamy V,Mahdi F,Jekabsons MB,Gerwick WH,Valeriote FA,Zhou YD,Nagle DGdoi
10.3390/md13031552subject
Has Abstractpub_date
2015-03-20 00:00:00pages
1552-68issue
3issn
1660-3397pii
md13031552journal_volume
13pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9040561
更新日期:2011-01-01 00:00:00
abstract::The red seaweed Pyropia yezoensis is an ideal research model for dissecting the molecular mechanisms underlying its robust acclimation to abiotic stresses in intertidal zones. Glycine betaine (GB) was an important osmolyte in maintaining osmotic balance and stabilizing the quaternary structure of complex proteins unde...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010070
更新日期:2019-01-21 00:00:00
abstract::Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114213
更新日期:2013-10-30 00:00:00
abstract::Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030093
更新日期:2018-03-13 00:00:00
abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050307
更新日期:2019-05-24 00:00:00
abstract::Cyclic imine toxins are neurotoxic, macrocyclic compounds produced by marine dinoflagellates. Mass spectrometric screenings of extracts from natural plankton assemblages revealed a high chemical diversity among this toxin class, yet only few toxins are structurally known. Here we report the structural characterization...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110446
更新日期:2018-11-14 00:00:00
abstract::Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030187
更新日期:2019-03-22 00:00:00
abstract::A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16030090
更新日期:2018-03-12 00:00:00
abstract::The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18120622
更新日期:2020-12-07 00:00:00
abstract::Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone dea...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md16050175
更新日期:2018-05-22 00:00:00
abstract::During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110525
更新日期:2020-10-23 00:00:00
abstract::Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17070418
更新日期:2019-07-19 00:00:00
abstract::Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8041106
更新日期:2010-04-01 00:00:00
abstract::Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md10050963
更新日期:2012-05-01 00:00:00
abstract::Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090278
更新日期:2017-08-31 00:00:00
abstract::Marine natural products are a source of promising agents for cancer treatment. However, there is a need to improve the evaluation of their mechanism of action in tumors. Metabolomics of the response to anti-tumor agents is a tool to reveal candidate biomarkers and metabolic targets. We used two-dimensional high-resolu...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11103846
更新日期:2013-10-11 00:00:00
abstract::Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040101
更新日期:2018-03-23 00:00:00
abstract::Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15100301
更新日期:2017-09-30 00:00:00
abstract::Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15060165
更新日期:2017-06-06 00:00:00
abstract::Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14040078
更新日期:2016-04-13 00:00:00
abstract::The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040104
更新日期:2018-03-26 00:00:00
abstract::Drug-resistant Staphylococcus aureus is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple S. aureus strains, including current drug-resistant ones, are needed. Previously, we have described...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10051103
更新日期:2012-05-01 00:00:00
abstract::Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9122553
更新日期:2011-12-01 00:00:00
abstract::This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010655
更新日期:2015-01-19 00:00:00
abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10030639
更新日期:2012-03-01 00:00:00
abstract::The skin, the largest organ in humans, is exposed to major sources of outdoor air pollution, such as fine particulate matter with a diameter ≤ 2.5 µm (PM2.5). Diphlorethohydroxycarmalol (DPHC), a marine-based compound, possesses multiple activities including antioxidant effects. In the present study, we evaluated the ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17020095
更新日期:2019-02-01 00:00:00
abstract::Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100586
更新日期:2019-10-16 00:00:00
abstract::Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in water, but upon interaction with lipid bilayers, they oligomerize to form a po...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13041647
更新日期:2015-03-25 00:00:00
abstract::Oceans have shown to be a remarkable source of natural products. The biological properties of many of these compounds have helped to produce great advances in medicinal chemistry. Within them, marine natural products containing an oxepanyl ring are present in a great variety of algae, sponges, fungus and corals and sh...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15110361
更新日期:2017-11-15 00:00:00
abstract::The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS) P. shigelloides Polish Collection of Microorganisms (PCM) 2231 (serotype O17) was investigated by (1)H, (13)C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is compo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11020440
更新日期:2013-02-06 00:00:00