Abstract：
:Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1-3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Bonnard I,Jhaumeer-Laulloo SB,Bontemps N,Banaigs B,Aknin Mdoi
10.3390/md8020359subject
Has Abstractpub_date
2010-02-23 00:00:00pages
359-72issue
2issn
1660-3397journal_volume
8pub_type
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