Cyclic marinopyrrole derivatives as disruptors of Mcl-1 and Bcl-x(L) binding to Bim.

abstract：:Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...

journal_title：Marine drugs

authors： Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

更新日期：2020-11-29 00:00:00

abstract：:Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod Temora longicornis. Production of DMS can rapidly increase following ...

journal_title：Marine drugs

authors： Breckels MN,Bode NW,Codling EA,Steinke M

更新日期：2013-07-15 00:00:00

abstract：:This study aimed to investigate the cardiovascular effects elicited by Dictyota pulchella, a brown alga, using in vivo and in vitro approaches. In normotensive conscious rats, CH(2)Cl(2)/MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella produced dose-dependent hypotension (-4 ± 1; -8 ± 2; -53 ± 8 and ...

journal_title：Marine drugs

authors： Queiroz TM,Machado NT,Furtado FF,Oliveira-Filho AA,Alustau MC,Figueiredo CS,Miranda GE,Barbosa-Filho JM,Braga VA,Medeiros IA

更新日期：2011-01-01 00:00:00

abstract：:A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a mo...

journal_title：Marine drugs

authors： Chung HM,Wang WH,Hwang TL,Fang LS,Wen ZH,Chen JJ,Wu YC,Sung PJ

更新日期：2014-12-04 00:00:00

abstract：:Red algae of the genus Plocamium have been a rich source of halogenated monoterpenes. Herein, a new cyclic monoterpene, costatone C (7), was isolated from the extract of P. angustum collected in New Zealand, along with the previously reported (1E,5Z)-1,6-dichloro-2-methylhepta-1,5-dien-3-ol (8). Elucidation of the pla...

journal_title：Marine drugs

authors： Bracegirdle J,Sohail Z,Fairhurst MJ,Gerth ML,Zuccarello GC,Ali Hashmi M,Keyzers RA

更新日期：2019-07-19 00:00:00

abstract：:A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...

journal_title：Marine drugs

authors： Chen TH,Lu MC,Chang YC,Su YD,Chen YH,Lin NC,Fang LS,Wu YC,Sung PJ

更新日期：2013-11-14 00:00:00

abstract：:The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...

journal_title：Marine drugs

authors： Pislyagin EA,Manzhulo IV,Gorpenchenko TY,Dmitrenok PS,Avilov SA,Silchenko AS,Wang YM,Aminin DL

更新日期：2017-11-01 00:00:00

abstract：:Astaxanthin is one of the strongest natural antioxidants and a red pigment occurring in nature. This C40 carotenoid is used in a broad range of applications such as a colorant in the feed industry, an antioxidant in cosmetics or as a supplement in human nutrition. Natural astaxanthin is on the rise and, hence, alterna...

journal_title：Marine drugs

authors： Henke NA,Wendisch VF

更新日期：2019-10-31 00:00:00

abstract：:Tuberculosis is the leading cause of death due to infectious disease worldwide. There is an urgent need for more effective compounds against this pathogen to control the disease. Investigation of the anti-mycobacterial activity of a deep-water sponge of the genus Plakina revealed the presence of a new steroidal alkalo...

journal_title：Marine drugs

authors： Rodrigues Felix C,Roberts JC,Winder PL,Gupta R,Diaz MC,Pomponi SA,Wright AE,Rohde KH

更新日期：2019-12-16 00:00:00

abstract：:Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats with ALP at various ...

journal_title：Marine drugs

authors： Sadegh Vishkaei M,Ebrahimpour A,Abdul-Hamid A,Ismail A,Saari N

更新日期：2016-09-30 00:00:00

abstract：:In this study, as part of our continuous search for environmentally-friendly antifoulants from natural resources, subergorgic acid (SA) was identified from the gorgonian coral Subergorgia suberosa, demonstrating non-toxic, significant inhibitory effects (EC50 1.25 μg/mL, LC50 > 25 μg/mL) against the settlement of Bala...

journal_title：Marine drugs

authors： Zhang J,Ling W,Yang Z,Liang Y,Zhang L,Guo C,Wang K,Zhong B,Xu S,Xu Y

更新日期：2019-02-06 00:00:00

abstract：:Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...

journal_title：Marine drugs

authors： Mansson M,Gram L,Larsen TO

更新日期：2011-01-01 00:00:00

abstract：:Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. In fact, collagen derived from alternative and riskless sources is requir...

journal_title：Marine drugs

authors： Benedetto CD,Barbaglio A,Martinello T,Alongi V,Fassini D,Cullorà E,Patruno M,Bonasoro F,Barbosa MA,Carnevali MD,Sugni M

更新日期：2014-09-24 00:00:00

abstract：:The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and can...

journal_title：Marine drugs

authors： Jackson SA,Crossman L,Almeida EL,Margassery LM,Kennedy J,Dobson ADW

更新日期：2018-02-20 00:00:00

abstract：:Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...

journal_title：Marine drugs

authors： Drotningsvik A,Vikøren LA,Mjøs SA,Oterhals Å,Pampanin D,Flesland O,Gudbrandsen OA

更新日期：2018-05-01 00:00:00

abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...

journal_title：Marine drugs

authors： Jøraholmen MW,Bhargava A,Julin K,Johannessen M,Škalko-Basnet N

更新日期：2020-01-31 00:00:00

abstract：:In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...

journal_title：Marine drugs

authors： da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MR

更新日期：2016-05-19 00:00:00

abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...

journal_title：Marine drugs

authors： Ding CYG,Pang LM,Liang ZX,Goh KKK,Glukhov E,Gerwick WH,Tan LT

更新日期：2018-12-13 00:00:00

abstract：:To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...

journal_title：Marine drugs

authors： Hsieh YL,Teng HJ,Yeh YH,Hsieh CH,Huang CY

更新日期：2018-08-01 00:00:00

abstract：:Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific abe...

journal_title：Marine drugs

authors： Essack M,Bajic VB,Archer JA

更新日期：2011-01-01 00:00:00

abstract：:Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...

journal_title：Marine drugs

authors： Xi Z,Bie W,Chen W,Liu D,van Ofwegen L,Proksch P,Lin W

更新日期：2013-08-26 00:00:00

abstract：:Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties ...

journal_title：Marine drugs

authors： Gopal R,Seo CH,Park Y

更新日期：2014-03-13 00:00:00

abstract：:Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

journal_title：Marine drugs

authors： Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

更新日期：2018-02-28 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a malignant tumor that can cause systemic invasion; however, the exact etiology and molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has efficient anti-oxidant, anti-inflammatory, and other activities, and has great research prospects in cancer therapy. We s...

journal_title：Marine drugs

authors： Li J,Dai W,Xia Y,Chen K,Li S,Liu T,Zhang R,Wang J,Lu W,Zhou Y,Yin Q,Abudumijiti H,Chen R,Zheng Y,Wang F,Lu J,Zhou Y,Guo C

更新日期：2015-09-24 00:00:00

abstract：:N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...

journal_title：Marine drugs

authors： Oda T,Lee JS,Sato Y,Kabe Y,Sakamoto S,Handa H,Mangindaan RE,Namikoshi M

更新日期：2009-11-17 00:00:00

abstract：:Ciguatoxins (CTXs) are marine toxins that cause ciguatera fish poisoning, a debilitating disease dominated by sensory and neurological disturbances that include cold allodynia and various painful symptoms as well as long-lasting pruritus. Although CTXs are known as the most potent mammalian sodium channel activator to...

journal_title：Marine drugs

authors： Touska F,Sattler S,Malsch P,Lewis RJ,Reeh PW,Zimmermann K

更新日期：2017-08-30 00:00:00

abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...

journal_title：Marine drugs

authors： Sepe V,Di Leva FS,D'Amore C,Festa C,De Marino S,Renga B,D'Auria MV,Novellino E,Limongelli V,D'Souza L,Majik M,Zampella A,Fiorucci S

更新日期：2014-05-27 00:00:00

abstract：:Collagen is involved in the formation of complex fibrillar networks, providing the structural integrity of tissues. Its low immunogenicity and mechanical properties make this molecule a biomaterial that is extremely suitable for tissue engineering and regenerative medicine (TERM) strategies in human health issues. Her...

journal_title：Marine drugs

authors： Pozzolini M,Scarfì S,Gallus L,Castellano M,Vicini S,Cortese K,Gagliani MC,Bertolino M,Costa G,Giovine M

更新日期：2018-03-29 00:00:00

abstract：:Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...

journal_title：Marine drugs

authors： Niu S,Yang L,Chen T,Hong B,Pei S,Shao Z,Zhang G

更新日期：2020-11-17 00:00:00

abstract：:Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...

journal_title：Marine drugs

authors： Rhodes LL,Smith KF,Murray S,Harwood DT,Trnski T,Munday R

更新日期：2017-07-11 00:00:00