Abstract:
:Prostate cancer (PCa), the most common malignancy in men, is a major cause of cancer deaths. A better understanding of the mechanisms that drive tumor initiation and progression may identify actionable targets to improve treatment of this patient group. As a dietary carotenoid, astaxanthin has been demonstrated to exert beneficial effects against inflammation, cardiovascular disease, oxidative damage, or different cancer sites. This study used intragastric administration of astaxanthin to detect its role on tumor proliferation, apoptosis, microRNA (miRNA) overexpression, and microbacteria composition change by establishing androgen-independent PCa cell PC-3 xenograft nude mice. Nude mice were inoculated with androgen-independent prostate cancer PC-3 cells subcutaneously. The intervention was started when tumors reached 0.5-0.6 cm in diameter. Mice were intragastrically administered 100 mg/kg astaxanthin (HA), 25 mg/kg astaxanthin (LA), or olive oil (TC). The results showed that 100 mg/kg astaxanthin significantly inhibited tumor growth compared to the TC group, with an inhibitory rate of 41.7%. A decrease of Ki67 and proliferating cell nuclear antigen (PCNA) as well as an increase of cleaved caspase-3 were observed in HA-treated tumors, along with increasing apoptotic cells, obtained by TUNEL assay. The HA significantly elevated the levels of tumor suppressors miR-375 and miR-487b in tumor tissues and the amount of Lactobacillus sp. and Lachnospiraceae in mice stools, while there was no significant difference between LA and TC groups. These results provide a promising regimen to enhance the therapeutic effect in a dietary supplement manner.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Ni X,Yu H,Wang S,Zhang C,Shen Sdoi
10.3390/md15030066subject
Has Abstractpub_date
2017-03-08 00:00:00issue
3issn
1660-3397pii
md15030066journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9030294
更新日期:2011-02-25 00:00:00
abstract::Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic ana...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15060177
更新日期:2017-06-15 00:00:00
abstract::Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15060165
更新日期:2017-06-06 00:00:00
abstract::Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their struct...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010046
更新日期:2019-01-10 00:00:00
abstract::Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced me...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020066
更新日期:2018-02-19 00:00:00
abstract::Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18080389
更新日期:2020-07-27 00:00:00
abstract::Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12041876
更新日期:2014-03-28 00:00:00
abstract::Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12084539
更新日期:2014-08-19 00:00:00
abstract::The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10122676
更新日期:2012-12-01 00:00:00
abstract::Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15060166
更新日期:2017-06-06 00:00:00
abstract::Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12073970
更新日期:2014-06-30 00:00:00
abstract::Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 wer...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15040085
更新日期:2017-03-23 00:00:00
abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031185
更新日期:2014-03-06 00:00:00
abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12042164
更新日期:2014-04-10 00:00:00
abstract::Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12073838
更新日期:2014-06-27 00:00:00
abstract::A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a mo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12125856
更新日期:2014-12-04 00:00:00
abstract::Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010276
更新日期:2015-01-07 00:00:00
abstract::In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17040234
更新日期:2019-04-19 00:00:00
abstract::The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040104
更新日期:2018-03-26 00:00:00
abstract::The effect of gold nanoparticles (GNPs) synthesized in marine algae has been described in the context of skin, where they have shown potential benefit. Ecklonia stolonifera (ES) is a brown algae that belongs to the Laminariaceae family, and is widely used as a component of food and medicine due to its biological activ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18090433
更新日期:2020-08-19 00:00:00
abstract::An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9010109
更新日期:2011-01-21 00:00:00
abstract::Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compoun...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14060111
更新日期:2016-06-03 00:00:00
abstract::Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030144
更新日期:2019-03-01 00:00:00
abstract::The marine ecosystem has been a key resource for secondary metabolites with promising biological roles. In the current study, bioassay-guided phytochemical investigations were carried out to assess the presence of enzyme inhibitory chemical constituents from the methanolic extract of marine green alga-Codium dwarkense...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13074344
更新日期:2015-07-14 00:00:00
abstract::MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc). MytiLec revealed β-trefoil folding as also found in the ricin B-subunit type (R-type) lectin family, although the amino acid sequences were quite different....
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13127071
更新日期:2015-12-14 00:00:00
abstract::Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030186
更新日期:2019-03-21 00:00:00
abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070219
更新日期:2017-07-11 00:00:00
abstract::In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18030133
更新日期:2020-02-26 00:00:00
abstract::Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15060146
更新日期:2017-05-25 00:00:00
abstract::Seaweed is a rich source of bioactive sulfated polysaccharides. We obtained six sulfated polysaccharide-rich fractions (UF-0.3, UF-0.5, UF-0.6, UF-0.7, UF-1.0, and UF-2.0) from the green seaweed Udotea flabellum (UF) by proteolytic digestion followed by sequential acetone precipitation. Biochemical analysis of these f...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040135
更新日期:2018-04-20 00:00:00