Abstract：
:A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambiguously elucidated based on HRESIMS and exhaustive 1D and 2D NMR spectral analysis as well as a comparison of their NMR data with those of jasplakinolide (1). The isolated jasplakinolides inhibited the growth of mouse lymphoma (L5178Y) cells in vitro with IC50 values in the low micromolar to nanomolar range.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Ebada SS,Müller WEG,Lin W,Proksch Pdoi
10.3390/md17020100subject
Has Abstractpub_date
2019-02-06 00:00:00issue
2issn
1660-3397pii
md17020100journal_volume
17pub_type
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