Abstract：
:In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated fatty acids (PUFAs) like n-3 α-linolenic (ALA 18:3), eicosapentaenoic (EPA, 20:5) and docosahexaenoic (DHA, 22:6). GLs comprise three major classes: monogalactosyldiacyl glycerolipids (MGDGs), digalactosyl diacylglycerolipids (DGDGs) and sulfoquinovosyl diacylglycerolipids (SQDGs), whose composition in FA directly depends on the growth conditions. Some of these lipids are high value-added compounds with antitumoral, antimicrobial and anti-inflammatory activities and also with important nutritional significance. To fully explore GLs' bioactive properties it is necessary to fully characterize their structure and to understand the relation between the structure and their biological properties, which can be addressed using modern mass spectrometry (MS)-based lipidomic approaches. This review will focus on the up-to-date FA composition of GLs identified by MS-based lipidomics and their potential as phytochemicals.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MRdoi
10.3390/md14050101subject
Has Abstractpub_date
2016-05-19 00:00:00issue
5issn
1660-3397pii
md14050101journal_volume
14pub_type
杂志文章,评审相关文献
Marine Drugs文献大全abstract：:In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030133
更新日期：2020-02-26 00:00:00
abstract：:The genus Streptomyces produces secondary metabolic compounds that are rich in biological activity. Many of these compounds are genetically encoded by large secondary metabolism biosynthetic gene clusters (smBGCs) such as polyketide synthases (PKS) and non-ribosomal peptide synthetases (NRPS) which are modular and can...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16020067
更新日期：2018-02-20 00:00:00
abstract：:Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15100251
更新日期：2017-09-26 00:00:00
abstract：:Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11093517
更新日期：2013-09-17 00:00:00
abstract：:Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md20080023
更新日期：2008-01-01 00:00:00
abstract：:Astaxanthin (AXT), a xanthophyll carotenoid compound, has potent antioxidant, anti-inflammatory and neuroprotective properties. Neuroinflammation and oxidative stress are significant in the pathogenesis and development of Alzheimer's disease (AD). Here, we studied whether AXT could alleviate neuroinflammation, oxidati...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020123
更新日期：2019-02-18 00:00:00
abstract：:A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16030090
更新日期：2018-03-12 00:00:00
abstract：:To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17120698
更新日期：2019-12-12 00:00:00
abstract：:Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13095784
更新日期：2015-09-15 00:00:00
abstract：:Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070219
更新日期：2017-07-11 00:00:00
abstract：:Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. In fact, collagen derived from alternative and riskless sources is requir...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12094912
更新日期：2014-09-24 00:00:00
abstract：:One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12074110
更新日期：2014-07-08 00:00:00
abstract：:Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal the...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030064
更新日期：2017-03-04 00:00:00
abstract：:Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：
更新日期：2007-11-13 00:00:00
abstract：:The marine genus Pseudoalteromonas is known for its versatile biotechnological potential with respect to the production of antimicrobials and enzymes of industrial interest. We have sequenced the genomes of three Pseudoalteromonas sp. strains isolated from different deep sea sponges on the Illumina MiSeq platform. The...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15060184
更新日期：2017-06-19 00:00:00
abstract：:Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18010059
更新日期：2020-01-16 00:00:00
abstract：:Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structure...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18090454
更新日期：2020-08-30 00:00:00
abstract：:Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17080472
更新日期：2019-08-15 00:00:00
abstract：:Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divid...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16010016
更新日期：2018-01-08 00:00:00
abstract：:D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md7010045
更新日期：2009-01-01 00:00:00
abstract：:The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110341
更新日期：2017-11-01 00:00:00
abstract：:In order to search for sulfated polysaccharides in different invertebrate connective tissues and to examine their biological activities, we have isolated three types of polysaccharides from the body wall of the three sea cucumbers Holothuria edulis, Apostichopus japonicas and Holothuria nobilis. The physicochemical pr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11020399
更新日期：2013-02-05 00:00:00
abstract：:The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13117040
更新日期：2015-11-19 00:00:00
abstract：:In this study, as part of our continuous search for environmentally-friendly antifoulants from natural resources, subergorgic acid (SA) was identified from the gorgonian coral Subergorgia suberosa, demonstrating non-toxic, significant inhibitory effects (EC50 1.25 μg/mL, LC50 > 25 μg/mL) against the settlement of Bala...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020101
更新日期：2019-02-06 00:00:00
abstract：:Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18070349
更新日期：2020-07-03 00:00:00
abstract：:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12031569
更新日期：2014-03-14 00:00:00
abstract：:In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11041061
更新日期：2013-03-28 00:00:00
abstract：:Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16010018
更新日期：2018-01-09 00:00:00
abstract：:Fish consumption is a potential route of human exposure to the hepatotoxic microcystins, especially in lakes and reservoirs that routinely experience significant toxic Microcystis blooms. Understanding the rates of uptake and elimination for microcystins as well as the transfer efficiency into tissues of consumers are...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9122553
更新日期：2011-12-01 00:00:00
abstract：:Sea cucumbers have been valued for many centuries as a tonic and functional food, dietary delicacies and important ingredients of traditional medicine in many Asian countries. An assortment of bioactive compounds has been described in sea cucumbers. The most important and abundant secondary metabolites from sea cucumb...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14080147
更新日期：2016-08-04 00:00:00
