Abstract:
:Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal therapy; the chitosan-based nanosystem could both provide antifungal effects and simultaneously deliver antibacterial drugs. We prepared chitosan-containing liposomes, chitosomes, where chitosan is both embedded in liposomes and surface-available as a coating layer. For antimicrobial activity, we entrapped metronidazole as a model drug. To prove that mucoadhesivness alone is not sufficient for successful delivery, we used Carbopol-containing liposomes as a control. All vesicles were characterized for their size, zeta potential, entrapment efficiency, and in vitro drug release. Chitosan-containing liposomes were able to assure the prolonged release of metronidazole. Their antifungal activity was evaluated in a C. albicans model; chitosan-containing liposomes exhibited a potent ability to inhibit the growth of C. albicans. The presence of chitosan was crucial for the system's antifungal activity. The antifungal efficacy of chitosomes combined with antibacterial potential of the entrapped metronidazole could offer improved efficacy in the treatment of mixed/complex vaginal infections.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Andersen T,Mishchenko E,Flaten GE,Sollid JU,Mattsson S,Tho I,Škalko-Basnet Ndoi
10.3390/md15030064subject
Has Abstractpub_date
2017-03-04 00:00:00issue
3issn
1660-3397pii
md15030064journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::In aquatic microbial ecology, knowledge of the processes involved in the turnover of organic matter is of utmost importance to understand ecosystem functioning. Microorganisms are major players in the cycling of nutrients (nitrogen, phosphorus) and carbon, thanks to their enzymatic activities (leucine aminopeptidase, ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8040916
更新日期:2010-03-29 00:00:00
abstract::Mycothiazole, a polyketide metabolite isolated from the marine sponge Cacospongia mycofijiensis, is a potent inhibitor of metabolic activity and mitochondrial electron transport chain complex I in sensitive cells, but other cells are relatively insensitive to the drug. Sensitive cell lines (IC(50) 0.36-13.8 nM) includ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10040900
更新日期:2012-04-01 00:00:00
abstract::The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14050094
更新日期:2016-05-12 00:00:00
abstract::Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as "Vulnerable" on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17090504
更新日期:2019-08-28 00:00:00
abstract:UNLABELLED:Cod-liver oil and other marine products containing polyunsaturated fatty acids have anti-inflammatory, anti-bacterial and anti-viral effects and may be useful in the treatment of various inflammatory and infectious diseases. We developed suppositories and ointment with 30% free fatty acid (FFA) extract from ...
journal_title:Marine drugs
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3390/md10092047
更新日期:2012-09-01 00:00:00
abstract::There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14060118
更新日期:2016-06-21 00:00:00
abstract::In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the cultur...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16070229
更新日期:2018-07-06 00:00:00
abstract::Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16120505
更新日期:2018-12-13 00:00:00
abstract::The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15110341
更新日期:2017-11-01 00:00:00
abstract::Numerous studies have suggested that hyperlipidemia is closely linked to cardiovascular disease. The aim of this study was to investigate the possible antihyperlipidemia mechanism of HU (high sulfate content of ulvan) in high-cholesterol fed rats. Wistar rats were made hyperlipidemic by feeding with a high-cholesterol...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13063407
更新日期:2015-05-29 00:00:00
abstract::Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14070130
更新日期:2016-07-08 00:00:00
abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050307
更新日期:2019-05-24 00:00:00
abstract::D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md7010045
更新日期:2009-01-01 00:00:00
abstract::In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12115503
更新日期:2014-11-19 00:00:00
abstract::The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020879
更新日期:2015-02-10 00:00:00
abstract::Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12073838
更新日期:2014-06-27 00:00:00
abstract::Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8041106
更新日期:2010-04-01 00:00:00
abstract::Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the s...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18090471
更新日期:2020-09-18 00:00:00
abstract::One of the most distinctive and defining features of coleoid cephalopods-squid, cuttlefish and octopus-is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12052700
更新日期:2014-05-12 00:00:00
abstract::Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 positions via a Crimmins-mo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15010017
更新日期:2017-01-18 00:00:00
abstract::Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020063
更新日期:2018-02-15 00:00:00
abstract::Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010597
更新日期:2015-01-16 00:00:00
abstract::Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11082882
更新日期:2013-08-13 00:00:00
abstract::Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md20080023
更新日期:2008-01-01 00:00:00
abstract::In this study, we developed novel chitosan/fucoidan nanoparticles (CS/F NPs) using a simple polyelectrolyte self-assembly method and evaluated their potential to be antioxidant carriers. As the CS/F weight ratio was 5/1, the CS/F NPs were spherical and exhibited diameters of approximately 230-250 nm, as demonstrated b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12084379
更新日期:2014-07-31 00:00:00
abstract::A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglyc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13084934
更新日期:2015-08-06 00:00:00
abstract::Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysac...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md8041305
更新日期:2010-04-19 00:00:00
abstract::The crustacean processing industry produces large quantities of waste by-products (up to 70%). Such wastes could be used as raw materials for producing chitosan, a polysaccharide with a unique set of biochemical properties. However, the preparation methods and the long-term stability of chitosan-based products limit t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010048
更新日期:2019-01-10 00:00:00
abstract::The term metabolic/cardiometabolic/insulin resistance syndrome could generally be defined as the co-occurrence of several risk factors inclusive of systemic arterial hypertension. Not only that organizations, such as the world health organization (WHO) have identified high blood pressure as one of the main risk factor...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17110613
更新日期:2019-10-29 00:00:00
abstract::The discovery of new bioactive compounds from marine natural sources is very important in pharmacological research. Here we developed a Wnt responsive luciferase reporter assay to screen small molecule inhibitors of cancer associated constitutive Wnt signaling pathway. We identified that gliotoxin (GTX) and some of it...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13106259
更新日期:2015-10-02 00:00:00