Abstract：
:One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found to induce adiponectin production in murine ST-13 preadipocyte cells but the α-pyrone 1 had no activity. The absolute configuration of the anteiso-methyl branching in 4 was determined by HPLC comparison of a degraded product of 4 with standard samples as a 2:3 enantiomeric mixture of (R)- and (S)-isomers.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Kim Y,Ogura H,Akasaka K,Oikawa T,Matsuura N,Imada C,Yasuda H,Igarashi Ydoi
10.3390/md12074110subject
Has Abstractpub_date
2014-07-08 00:00:00pages
4110-25issue
7issn
1660-3397pii
md12074110journal_volume
12pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12010069
更新日期：2013-12-24 00:00:00
abstract：:The crustacean processing industry produces large quantities of waste by-products (up to 70%). Such wastes could be used as raw materials for producing chitosan, a polysaccharide with a unique set of biochemical properties. However, the preparation methods and the long-term stability of chitosan-based products limit t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010048
更新日期：2019-01-10 00:00:00
abstract：:Cone snails produce a distinctive repertoire of venom peptides that are used both as a defense mechanism and also to facilitate the immobilization and digestion of prey. These peptides target a wide variety of voltage- and ligand-gated ion channels, which make them an invaluable resource for studying the properties of...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10061244
更新日期：2012-06-01 00:00:00
abstract：:The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15040103
更新日期：2017-03-30 00:00:00
abstract：:The immunomodulatory effect of triterpene glycoside cucumarioside A₂-2 (CA₂-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage acti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110341
更新日期：2017-11-01 00:00:00
abstract：:Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11093297
更新日期：2013-08-28 00:00:00
abstract：:Three myxobacterial strains, designated SWB004, SWB005 and SWB006, were obtained from beach sand samples from the Pacific Ocean and the North Sea. The strains were cultivated in salt water containing media and subjected to studies to determine their taxonomic status, the presence of genes for the biosynthesis of polyk...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8092466
更新日期：2010-09-03 00:00:00
abstract：:Death-associated protein kinase 1 (DAPK1) expression induced by diverse death stimuli mediates apoptotic activity in various cancers, including ovarian cancer. In addition, mutual interaction between the tumor suppressor p53 and DAPK1 influences survival and death in several cancer cell lines. However, the exact role ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17070412
更新日期：2019-07-12 00:00:00
abstract：:Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13042105
更新日期：2015-04-13 00:00:00
abstract：:Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020101
更新日期：2020-02-04 00:00:00
abstract：:Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic ana...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15060177
更新日期：2017-06-15 00:00:00
abstract：:Cyclic imine toxins are neurotoxic, macrocyclic compounds produced by marine dinoflagellates. Mass spectrometric screenings of extracts from natural plankton assemblages revealed a high chemical diversity among this toxin class, yet only few toxins are structurally known. Here we report the structural characterization...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110446
更新日期：2018-11-14 00:00:00
abstract：:Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18040228
更新日期：2020-04-24 00:00:00
abstract：:Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11093517
更新日期：2013-09-17 00:00:00
abstract：:The biologically active lipopeptide kalkitoxin was previously isolated from the marine cyanobacterium Moorea producens (Lyngbya majuscula). Kalkitoxin exhibited N-methyl-D-aspartate (NMDA)-mediated neurotoxicity and acted as an inhibitory ligand for voltage-sensitive sodium channels in cultured rat cerebellar granule ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13031552
更新日期：2015-03-20 00:00:00
abstract：:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14010001
更新日期：2015-12-22 00:00:00
abstract：:Three new benzofuranoids, asperfuranoids A-C (1-3), two new phenylpropanoid derivatives (6 and 7), and nine known analogues (4, 5, and 8-14) were isolated from the liquid substrate fermentation cultures of the mangrove endopytic fungus Aspergillus sp. ZJ-68. The structures of the new compounds were determined by exten...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17080478
更新日期：2019-08-18 00:00:00
abstract：:In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114510
更新日期：2013-11-12 00:00:00
abstract：:Accurate characterization of biomass constituents is a crucial aspect of research in the biotechnological application of natural products. Here we report an efficient, fast and reproducible method for the identification and quantitation of fatty acids and complex lipids (triacylglycerols, glycolipids, phospholipids) i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11103742
更新日期：2013-09-30 00:00:00
abstract：:In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11041061
更新日期：2013-03-28 00:00:00
abstract：:Drug-resistant Staphylococcus aureus is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple S. aureus strains, including current drug-resistant ones, are needed. Previously, we have described...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10051103
更新日期：2012-05-01 00:00:00
abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063091
更新日期：2014-05-27 00:00:00
abstract：:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12115503
更新日期：2014-11-19 00:00:00
abstract：:Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040101
更新日期：2018-03-23 00:00:00
abstract：:Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13116884
更新日期：2015-11-13 00:00:00
abstract：:Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of th...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13010276
更新日期：2015-01-07 00:00:00
abstract：:Green seaweeds are rich sources of sulfated polysaccharides (SPs) with potential biomedical and nutraceutical applications. The aim of this work was to evaluate the immunostimulatory activity of SPs from the seaweed, Caulerpa cupressoides var. flabellata on murine RAW 264.7 macrophages. SPs were evaluated for their ab...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020105
更新日期：2019-02-09 00:00:00
abstract：:Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110441
更新日期：2018-11-09 00:00:00
abstract：:Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumula...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15020039
更新日期：2017-02-15 00:00:00
abstract：:The purpose of this study was to develop a pharmaceutical formulation containing fatty acid extract rich in free omega-3 fatty acids such as eicosapentaenoic acid and docosahexaenoic acid for topical use. Although the health benefits of cod liver oil and other fish oils taken orally as a dietary supplement have been a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14060105
更新日期：2016-06-01 00:00:00
