Abstract:
:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at concentrations from 500 to 50 μg mL-1. The molecular characterization, based on the internal transcribed spacer (ITS) region sequences (ITS1, 5.8S and ITS2) between the rRNA of 18S and 28S, identified these strains as belonging to four genera: Sarocladium (LAEE06), Fusarium (LAEE13), Epicoccum (LAEE14), and Khuskia (LAEE21). Interestingly, three came from coral species and two of them came from the same organism, the coral Diploria strigosa. Metabolic profiles obtained by Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) suggest that a combination of fungal secondary metabolites and fatty acids could be the responsible for the observed activities. The LC-HRMS analysis also revealed the presence of potentially new secondary metabolites. This is, to the best of our knowledge, the first report of QS inhibition by marine endophytic fungi.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Martín-Rodríguez AJ,Reyes F,Martín J,Pérez-Yépez J,León-Barrios M,Couttolenc A,Espinoza C,Trigos A,Martín VS,Norte M,Fernández JJdoi
10.3390/md12115503subject
Has Abstractpub_date
2014-11-19 00:00:00pages
5503-26issue
11issn
1660-3397pii
md12115503journal_volume
12pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100543
更新日期:2019-09-21 00:00:00
abstract::Cyclic imine toxins are neurotoxic, macrocyclic compounds produced by marine dinoflagellates. Mass spectrometric screenings of extracts from natural plankton assemblages revealed a high chemical diversity among this toxin class, yet only few toxins are structurally known. Here we report the structural characterization...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16110446
更新日期:2018-11-14 00:00:00
abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md11093381
更新日期:2013-09-06 00:00:00
abstract::The present study is focused on the intestinal absorption of sea cucumber saponins. We determined the pharmacokinetic characteristics and bioavailability of Echinoside A and Holotoxin A₁; the findings indicated that the bioavailability of Holotoxin A₁ was lower than Echinoside A. We inferred that the differences in ch...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14060114
更新日期:2016-06-17 00:00:00
abstract::Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13116884
更新日期:2015-11-13 00:00:00
abstract::Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable anti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040117
更新日期:2018-04-05 00:00:00
abstract::A new alkaloid, 2-(furan-2-yl)-6-(2S,3S,4-trihydroxybutyl)pyrazine (1), along with 12 known compounds, 2-(furan-2-yl)-5-(2S,3S,4-trihydroxybutyl)pyrazine (2), (S)-4-isobutyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde (3), (S)-4-isopropyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyd...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12010477
更新日期:2014-01-21 00:00:00
abstract::Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their struct...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010046
更新日期:2019-01-10 00:00:00
abstract::In the course of studies on bioactive metabolites from marine fungi, a new 10-membered lactone, named penicillinolide A (1) was isolated from the organic extract of Penicillium sp. SF-5292 as a potential anti-inflammatory compound. The structure of penicillinolide A (1) was mainly determined by analysis of NMR and MS ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114510
更新日期:2013-11-12 00:00:00
abstract::Seagrasses are high plants sharing adaptive metabolic features with both terrestrial plants and marine algae, resulting in a phytocomplex possibly endowed with interesting biological properties. The aim of this study is to evaluate the in vitro activities on skin cells of an ethanolic extract obtained from the leaves ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16010021
更新日期:2018-01-10 00:00:00
abstract::A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010003
更新日期:2018-12-20 00:00:00
abstract::Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md9112176
更新日期:2011-01-01 00:00:00
abstract::Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19010008
更新日期:2020-12-27 00:00:00
abstract::In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA-ALG-Cu2+) composite f...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18120660
更新日期:2020-12-21 00:00:00
abstract::In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the cultur...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16070229
更新日期:2018-07-06 00:00:00
abstract::Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute con...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110596
更新日期:2019-10-23 00:00:00
abstract::Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18100517
更新日期:2020-10-16 00:00:00
abstract::Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3⁻6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the provi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16090307
更新日期:2018-09-01 00:00:00
abstract::Three new benzofuranoids, asperfuranoids A-C (1-3), two new phenylpropanoid derivatives (6 and 7), and nine known analogues (4, 5, and 8-14) were isolated from the liquid substrate fermentation cultures of the mangrove endopytic fungus Aspergillus sp. ZJ-68. The structures of the new compounds were determined by exten...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17080478
更新日期:2019-08-18 00:00:00
abstract::One of the most distinctive and defining features of coleoid cephalopods-squid, cuttlefish and octopus-is their inking behavior. Their ink, which is blackened by melanin, but also contains other constituents, has been used by humans in various ways for millennia. This review summarizes our current knowledge of cephalo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12052700
更新日期:2014-05-12 00:00:00
abstract::Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18020101
更新日期:2020-02-04 00:00:00
abstract::The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030153
更新日期:2019-03-05 00:00:00
abstract::The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12074231
更新日期:2014-07-23 00:00:00
abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050307
更新日期:2019-05-24 00:00:00
abstract::In the present study, 13 bromopyrrole alkaloids, including the oroidin analogs hymenidin (2), dispacamide B (3) and dispacamide D (4), stevensine (5) and spongiacidin B (6), their derivatives lacking the imidazole ring bromoaldisin (7), longamide B (8) and longamide A (9), the dimeric oroidin derivatives sceptrin (10)...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8072162
更新日期:2010-07-14 00:00:00
abstract::The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13095947
更新日期:2015-09-18 00:00:00
abstract::Acute myeloid leukemia (AML) is a heterogeneous myeloid clonal disorder exhibiting the accumulation of immature myeloid progenitors in the bone marrow and peripheral blood. Standard AML therapy requires intensive combination chemotherapy, which leads to significant treatment-related toxicity. The search for new, low t...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14110205
更新日期:2016-11-03 00:00:00
abstract::Nemerteans (ribbon worms) employ toxins to subdue their prey, but research thus far has focused on the small-molecule components of mucus secretions and few protein toxins have been characterized. We carried out a preliminary proteotranscriptomic analysis of putative toxins produced by the hoplonemertean Amphiporus la...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080407
更新日期:2020-08-01 00:00:00
abstract::24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its underlying mechani...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070210
更新日期:2017-07-01 00:00:00
abstract::Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110561
更新日期:2020-11-17 00:00:00