Abstract：
:A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate cancer DU145 and colorectal cancer HCT116 cell lines (IC50 = 11.9, and 12.5 nM, respectively).
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Matsubara T,Yokoya M,Sirimangkalakitti N,Saito Ndoi
10.3390/md17010003subject
Has Abstractpub_date
2018-12-20 00:00:00issue
1issn
1660-3397pii
md17010003journal_volume
17pub_type
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