Abstract：
:Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties of AMPs. In this review, therefore, we will focus on the physiochemical properties of AMPs; that is, the contributions made by their sequences, net charge, hydrophobicity and amphipathicity to their mechanism of action. Moreover, the interactions between LPS and fish AMPs and the structure of fish AMPs with LPS bound will also be discussed. A better understanding of the biophysical properties will be useful in the design of AMPs effective against septic shock and multidrug-resistant bacterial strains, including those that commonly produce wound infections.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Gopal R,Seo CH,Park Ydoi
10.3390/md12031471subject
Has Abstractpub_date
2014-03-13 00:00:00pages
1471-94issue
3issn
1660-3397pii
md12031471journal_volume
12pub_type
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