Seaweed hydrocolloid production: an update on enzyme assisted extraction and modification technologies.

abstract：:Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod Temora longicornis. Production of DMS can rapidly increase following ...

journal_title：Marine drugs

authors： Breckels MN,Bode NW,Codling EA,Steinke M

更新日期：2013-07-15 00:00:00

abstract：:Chitosan is the N-deacetylated derivative of chitin, a naturally abundant mucopolysaccharide that consists of 2-acetamido-2-deoxy-β-d-glucose through a β (1→4) linkage and is found in nature as the supporting material of crustaceans, insects, etc. Chitosan has been strongly recommended as a suitable functional materia...

journal_title：Marine drugs

authors： Aranaz I,Gutiérrez MC,Ferrer ML,del Monte F

更新日期：2014-11-24 00:00:00

abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

journal_title：Marine drugs

authors： Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

更新日期：2015-03-30 00:00:00

abstract：:α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...

journal_title：Marine drugs

authors： Ren J,Li R,Ning J,Zhu X,Zhangsun D,Wu Y,Luo S

更新日期：2018-06-20 00:00:00

abstract：:Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced me...

journal_title：Marine drugs

authors： Zheng J,Cheng G,Li Q,Jiao S,Feng C,Zhao X,Yin H,Du Y,Liu H

更新日期：2018-02-19 00:00:00

abstract：:Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...

journal_title：Marine drugs

authors： Andersen AJC,de Medeiros LS,Binzer SB,Rasmussen SA,Hansen PJ,Nielsen KF,Jørgensen K,Larsen TO

更新日期：2017-08-31 00:00:00

abstract：:Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...

journal_title：Marine drugs

authors： Albarano L,Ruocco N,Ianora A,Libralato G,Manfra L,Costantini M

更新日期：2019-03-01 00:00:00

abstract：:Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...

journal_title：Marine drugs

authors： Shu Z,Liu Q,Xing C,Zhang Y,Zhou Y,Zhang J,Liu H,Cao M,Yang X,Liu G

更新日期：2020-10-16 00:00:00

abstract：:The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopi...

journal_title：Marine drugs

authors： Vilches TS,Norte M,Daranas AH,Fernández JJ

更新日期：2012-10-01 00:00:00

abstract：:This study aimed to investigate the cardiovascular effects elicited by Dictyota pulchella, a brown alga, using in vivo and in vitro approaches. In normotensive conscious rats, CH(2)Cl(2)/MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella produced dose-dependent hypotension (-4 ± 1; -8 ± 2; -53 ± 8 and ...

journal_title：Marine drugs

authors： Queiroz TM,Machado NT,Furtado FF,Oliveira-Filho AA,Alustau MC,Figueiredo CS,Miranda GE,Barbosa-Filho JM,Braga VA,Medeiros IA

更新日期：2011-01-01 00:00:00

abstract：:Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

journal_title：Marine drugs

authors： Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

更新日期：2017-12-04 00:00:00

abstract：:Accurate characterization of biomass constituents is a crucial aspect of research in the biotechnological application of natural products. Here we report an efficient, fast and reproducible method for the identification and quantitation of fatty acids and complex lipids (triacylglycerols, glycolipids, phospholipids) i...

journal_title：Marine drugs

authors： Nuzzo G,Gallo C,d'Ippolito G,Cutignano A,Sardo A,Fontana A

更新日期：2013-09-30 00:00:00

abstract：:There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...

journal_title：Marine drugs

authors： Costantino V,Della Sala G,Saurav K,Teta R,Bar-Shalom R,Mangoni A,Steindler L

更新日期：2017-02-28 00:00:00

abstract：:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration ...

journal_title：Marine drugs

authors： Zheng JJ,Shao CL,Chen M,Gan LS,Fang YC,Wang XH,Wang CY

更新日期：2014-03-14 00:00:00

abstract：:A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...

journal_title：Marine drugs

authors： Shikov AN,Pozharitskaya ON,Faustova NM,Kosman VM,Makarov VG,Razzazi-Fazeli E,Novak J

更新日期：2019-10-11 00:00:00

abstract：:The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...

journal_title：Marine drugs

authors： Mohsenian Kouchaksaraee R,Moridi Farimani M,Li F,Nazemi M,Tasdemir D

更新日期：2020-07-16 00:00:00

abstract：:Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...

journal_title：Marine drugs

authors： Wen J,Adams DJ,Hung A

更新日期：2020-07-03 00:00:00

abstract：:There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper...

journal_title：Marine drugs

authors： Luo Y,Chen H,Weng J,Lu G

更新日期：2016-06-21 00:00:00

abstract：:Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...

journal_title：Marine drugs

authors： Yang G,Mozzicafreddo M,Ballarini P,Pucciarelli S,Miceli C

更新日期：2021-01-27 00:00:00

abstract：:Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...

journal_title：Marine drugs

authors： Guo SX,Zhou HL,Huang CL,You CG,Fang Q,Wu P,Wang XG,Han CM

更新日期：2015-04-13 00:00:00

abstract：:Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinol...

journal_title：Marine drugs

authors： Yu J,Han H,Zhang X,Ma C,Sun C,Che Q,Gu Q,Zhu T,Zhang G,Li D

更新日期：2019-07-28 00:00:00

abstract：:A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...

journal_title：Marine drugs

authors： Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

更新日期：2018-12-20 00:00:00

abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

journal_title：Marine drugs

authors： Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

更新日期：2018-09-24 00:00:00

abstract：:Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...

journal_title：Marine drugs

authors： Žula A,Będziak I,Kikelj D,Ilaš J

更新日期：2018-10-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a malignant tumor that can cause systemic invasion; however, the exact etiology and molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has efficient anti-oxidant, anti-inflammatory, and other activities, and has great research prospects in cancer therapy. We s...

journal_title：Marine drugs

authors： Li J,Dai W,Xia Y,Chen K,Li S,Liu T,Zhang R,Wang J,Lu W,Zhou Y,Yin Q,Abudumijiti H,Chen R,Zheng Y,Wang F,Lu J,Zhou Y,Guo C

更新日期：2015-09-24 00:00:00

abstract：:The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...

journal_title：Marine drugs

authors： Ermolenko EV,Imbs AB,Gloriozova TA,Poroikov VV,Sikorskaya TV,Dembitsky VM

更新日期：2020-12-02 00:00:00

abstract：:Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

journal_title：Marine drugs

authors： Lopes VM,Lopes AR,Costa P,Rosa R

更新日期：2013-09-06 00:00:00

abstract：:Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated...

journal_title：Marine drugs

authors： Shi T,Qi J,Shao CL,Zhao DL,Hou XM,Wang CY

更新日期：2017-05-25 00:00:00

abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...

journal_title：Marine drugs

authors： Liang F,Li C,Hou T,Wen C,Kong S,Ma D,Sun C,Li S

更新日期：2020-08-10 00:00:00

abstract：:The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine...

journal_title：Marine drugs

authors： Vigani B,Rossi S,Gentile M,Sandri G,Bonferoni MC,Cavalloro V,Martino E,Collina S,Ferrari F

更新日期：2019-03-05 00:00:00