Abstract：
:Two new guaiazulene-based analogues, ochracenoids A (1) and B (2), along with four known analogues (3-6), were isolated from the gorgonian Anthogorgia ochracea collected from the South China Sea. The planar structures of the new compounds were elucidated by comprehensive spectroscopic data. The absolute configuration of 1 was determined as 3R by the comparison of TDDFT calculated electronic circular dichroism with its experimental spectrum. Compound 1 is a rare guaiazulene-based analogue possessing a unique C₁₆ skeleton. The possible generation process of 1 through an intermolecular one-carbon-transfer reaction was also discussed. Compound 2 was previously described as a presumed intermediate involved in the biogenesis of anthogorgienes A and I. Compound 3 exhibited antiproliferative effects on the embryo development of zebrafish Danio rerio.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Zheng JJ,Shao CL,Chen M,Gan LS,Fang YC,Wang XH,Wang CYdoi
10.3390/md12031569subject
Has Abstractpub_date
2014-03-14 00:00:00pages
1569-79issue
3issn
1660-3397pii
md12031569journal_volume
12pub_type
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