Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis.


:Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structures were determined by NMR and MS methods. The compounds 1, 2, 4, 6, and 7 inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.


Mar Drugs


Marine drugs


Shubina LK,Makarieva TN,Denisenko VA,Popov RS,Dyshlovoy SA,Grebnev BB,Dmitrenok PS,von Amsberg G,Stonik VA




Has Abstract


2020-08-30 00:00:00










  • The role of biophysical parameters in the antilipopolysaccharide activities of antimicrobial peptides from marine fish.

    abstract::Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Gopal R,Seo CH,Park Y

    更新日期:2014-03-13 00:00:00

  • Comparison of physicochemical characteristics and anticoagulant activities of polysaccharides from three sea cucumbers.

    abstract::In order to search for sulfated polysaccharides in different invertebrate connective tissues and to examine their biological activities, we have isolated three types of polysaccharides from the body wall of the three sea cucumbers Holothuria edulis, Apostichopus japonicas and Holothuria nobilis. The physicochemical pr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Luo L,Wu M,Xu L,Lian W,Xiang J,Lu F,Gao N,Xiao C,Wang S,Zhao J

    更新日期:2013-02-05 00:00:00

  • The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning.

    abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Rhodes LL,Smith KF,Murray S,Harwood DT,Trnski T,Munday R

    更新日期:2017-07-11 00:00:00

  • Understanding nanocalcification: a role suggested for crystal ghosts.

    abstract::The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bonucci E

    更新日期:2014-07-23 00:00:00

  • Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans.

    abstract::Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and a...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Neupane RP,Parrish SM,Neupane JB,Yoshida WY,Yip MLR,Turkson J,Harper MK,Head JD,Williams PG

    更新日期:2019-07-19 00:00:00

  • A lactose-binding lectin from the marine sponge Cinachyrella apion (Cal) induces cell death in human cervical adenocarcinoma cells.

    abstract::Cancer represents a set of more than 100 diseases, including malignant tumors from different locations. Strategies inducing differentiation have had limited success in the treatment of established cancers. Marine sponges are a biological reservoir of bioactive molecules, especially lectins. Several animal and plant le...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Rabelo L,Monteiro N,Serquiz R,Santos P,Oliveira R,Oliveira A,Rocha H,Morais AH,Uchoa A,Santos E

    更新日期:2012-04-01 00:00:00

  • Ascidian Toxins with Potential for Drug Development.

    abstract::Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of the...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Watters DJ

    更新日期:2018-05-13 00:00:00

  • Anaerobic Digestion of Laminaria japonica Waste from Industrial Production Residues in Laboratory- and Pilot-Scale.

    abstract::The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Barbot YN,Thomsen C,Thomsen L,Benz R

    更新日期:2015-09-18 00:00:00

  • The antihyperlipidemic mechanism of high sulfate content ulvan in rats.

    abstract::Numerous studies have suggested that hyperlipidemia is closely linked to cardiovascular disease. The aim of this study was to investigate the possible antihyperlipidemia mechanism of HU (high sulfate content of ulvan) in high-cholesterol fed rats. Wistar rats were made hyperlipidemic by feeding with a high-cholesterol...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Qi H,Sheng J

    更新日期:2015-05-29 00:00:00

  • Integrating Molecular Networking and 1H NMR Spectroscopy for Isolation of Bioactive Metabolites from the Persian Gulf Sponge Axinella sinoxea.

    abstract::The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Mohsenian Kouchaksaraee R,Moridi Farimani M,Li F,Nazemi M,Tasdemir D

    更新日期:2020-07-16 00:00:00

  • Cultivation of Sponge-Associated Bacteria from Agelas sventres and Xestospongia muta Collected from Different Depths.

    abstract::Sponge-associated bacteria have been mostly cultured from shallow water (≤30 m) sponges, whereas only few studies targeted specimens from below 30 m. This study assessed the cultivability of bacteria from two marine sponges Xestospongia muta and Agelas sventres collected from shallow (<30 m), upper mesophotic (30-60 m...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Indraningrat AAG,Micheller S,Runderkamp M,Sauerland I,Becking LE,Smidt H,Sipkema D

    更新日期:2019-10-11 00:00:00

  • Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products.

    abstract::A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Matsubara T,Yokoya M,Sirimangkalakitti N,Saito N

    更新日期:2018-12-20 00:00:00

  • Primary screening of the bioactivity of brackishwater cyanobacteria: toxicity of crude extracts to Artemia salina larvae and Paracentrotus lividus embryos.

    abstract::Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lopes VR,Fernández N,Martins RF,Vasconcelos V

    更新日期:2010-03-05 00:00:00

  • New Acyclic Cytotoxic Jasplakinolide Derivative from the Marine Sponge Jaspis splendens.

    abstract::A new acylic jasplakinolide congener (2), another acyclic derivative requiring revision (4), together with two jasplakinolide derivatives including the parent compound jasplakinolide (1) were isolated from the Indonesian marine sponge Jaspis splendens. The chemical structures of the new and known compounds were unambi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ebada SS,Müller WEG,Lin W,Proksch P

    更新日期:2019-02-06 00:00:00

  • Cyanobacterial Metabolite Calothrixins: Recent Advances in Synthesis and Biological Evaluation.

    abstract::The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special interest due to their unique structural scaffolds and capacity to produce p...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Xu S,Nijampatnam B,Dutta S,Velu SE

    更新日期:2016-01-12 00:00:00

  • Emerging Technologies for the Extraction of Marine Phenolics: Opportunities and Challenges.

    abstract::Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Getachew AT,Jacobsen C,Holdt SL

    更新日期:2020-07-27 00:00:00

  • Chemical Diversity and Biological Activities of Marine Sponges of the Genus Suberea: A Systematic Review.

    abstract::Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: El-Demerdash A,Atanasov AG,Horbanczuk OK,Tammam MA,Abdel-Mogib M,Hooper JNA,Sekeroglu N,Al-Mourabit A,Kijjoa A

    更新日期:2019-02-12 00:00:00

  • Production of bioactive secondary metabolites by marine vibrionaceae.

    abstract::Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Mansson M,Gram L,Larsen TO

    更新日期:2011-01-01 00:00:00

  • In situ detection of antibiotic amphotericin B produced in Streptomyces nodosus using Raman microspectroscopy.

    abstract::The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Miyaoka R,Hosokawa M,Ando M,Mori T,Hamaguchi HO,Takeyama H

    更新日期:2014-05-13 00:00:00

  • Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice.

    abstract::Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced me...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zheng J,Cheng G,Li Q,Jiao S,Feng C,Zhao X,Yin H,Du Y,Liu H

    更新日期:2018-02-19 00:00:00

  • Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats.

    abstract::We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Choi MK,Lee J,Nam SJ,Kang YJ,Han Y,Choi K,Choi YA,Kwon M,Lee D,Song IS

    更新日期:2017-09-01 00:00:00

  • Biological activity of volatiles from marine and terrestrial bacteria.

    abstract::The antiproliferative activity of 52 volatile compounds released from bacteria was investigated in agar diffusion assays against medically important microorganisms and mouse fibroblasts. Furthermore, the activity of these compounds to interfere with the quorum-sensing-systems was tested with two different reporter str...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Schulz S,Dickschat JS,Kunze B,Wagner-Dobler I,Diestel R,Sasse F

    更新日期:2010-12-22 00:00:00

  • Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.

    abstract::There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Costantino V,Della Sala G,Saurav K,Teta R,Bar-Shalom R,Mangoni A,Steindler L

    更新日期:2017-02-28 00:00:00

  • 4-Acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent.

    abstract::Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV

    更新日期:2011-01-01 00:00:00

  • From Aggregates to Porous Three-Dimensional Scaffolds through a Mechanochemical Approach to Design Photosensitive Chitosan Derivatives.

    abstract::The crustacean processing industry produces large quantities of waste by-products (up to 70%). Such wastes could be used as raw materials for producing chitosan, a polysaccharide with a unique set of biochemical properties. However, the preparation methods and the long-term stability of chitosan-based products limit t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bardakova KN,Akopova TA,Kurkov AV,Goncharuk GP,Butnaru DV,Burdukovskii VF,Antoshin AA,Farion IA,Zharikova TM,Shekhter AB,Yusupov VI,Timashev PS,Rochev YA

    更新日期:2019-01-10 00:00:00

  • Dechdigliotoxins A-C, Three Novel Disulfide-Bridged Gliotoxin Dimers from Deep-Sea Sediment Derived Fungus Dichotomomyces cejpii.

    abstract::Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute con...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Liu Z,Fan Z,Sun Z,Liu H,Zhang W

    更新日期:2019-10-23 00:00:00

  • Antimicrobial and Anti-Proliferative Effects of Skin Mucus Derived from Dasyatis pastinaca (Linnaeus, 1758).

    abstract::Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Fuochi V,Li Volti G,Camiolo G,Tiralongo F,Giallongo C,Distefano A,Petronio Petronio G,Barbagallo I,Viola M,Furneri PM,Di Rosa M,Avola R,Tibullo D

    更新日期:2017-11-01 00:00:00

  • Anti-Thrombin, Anti-Adhesive, Anti-Migratory, and Anti-Proliferative Activities of Sulfated Galactans from the Tropical Green Seaweed, Udotea flabellum.

    abstract::In this study, sulfated polysaccharide-rich extracts were isolated from 22 tropical seaweeds (4 red, 11 brown, and 7 green) found in northeastern Brazil, and evaluated for the role of anticoagulant agents. Fifteen of the extracts showed anticoagulant activity, including all the extracts from green seaweeds. Udoteaflab...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Mendes Marques ML,Presa FB,Viana RLS,Costa MSSP,Amorim MOR,Bellan DL,Alves MGCF,Costa LS,Trindade ES,Rocha HAO

    更新日期:2018-12-21 00:00:00

  • Characterization of Properties and Transglycosylation Abilities of Recombinant α-Galactosidase from Cold-Adapted Marine Bacterium Pseudoalteromonas KMM 701 and Its C494N and D451A Mutants.

    abstract::A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

    更新日期:2018-09-24 00:00:00

  • Inhibitory activity of marine sponge-derived natural products against parasitic protozoa.

    abstract::In this study, thirteen sponge-derived terpenoids, including five linear furanoterpenes: furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and demethylfurospongin-4 (5); four linear meroterpenes: 2-(hexaprenylmethyl)-2-methylchromenol (6), 4-hydroxy-3-octaprenylbenzoic acid (7), 4-hydro...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Orhan I,Sener B,Kaiser M,Brun R,Tasdemir D

    更新日期:2010-01-15 00:00:00