Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge Haliclona gracilis.

Abstract:

:Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structures were determined by NMR and MS methods. The compounds 1, 2, 4, 6, and 7 inhibited the expression of prostate-specific antigen (PSA) in 22Rv1 tumor cells.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Shubina LK,Makarieva TN,Denisenko VA,Popov RS,Dyshlovoy SA,Grebnev BB,Dmitrenok PS,von Amsberg G,Stonik VA

doi

10.3390/md18090454

subject

Has Abstract

pub_date

2020-08-30 00:00:00

issue

9

issn

1660-3397

pii

md18090454

journal_volume

18

pub_type

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