Abstract：
:Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and absolute configurations were established from density functional theory (DFT) calculations of the GIAO NMR shielding tensors, and advanced Marfey's analysis of the N-MeLeu residue, respectively. Compounds 1 and 3 showed moderate inhibition of β-secretase 1 (BACE1), whereas 1-9 exhibited moderate to potent inhibition of growth of human glioma (U251) cells. Compounds 1-2 and 4-7 were also active against human pancreatic carcinoma (Panc-1) cells.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Neupane RP,Parrish SM,Neupane JB,Yoshida WY,Yip MLR,Turkson J,Harper MK,Head JD,Williams PGdoi
10.3390/md17070423subject
Has Abstractpub_date
2019-07-19 00:00:00issue
7issn
1660-3397pii
md17070423journal_volume
17pub_type
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