Aplisulfamines, new sulfoxide-containing metabolites from an aplidium tunicate: absolute stereochemistry at chiral sulfur and carbon atoms assigned through an original combination of spectroscopic and computational methods.


:Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute configuration at the three contiguous chiral centers present in the structures of both aplisulfamines, two at carbon and one at sulfur. This involved Electronic Circular Dichroism (ECD) studies, J-based configuration analysis and Density Functional Theory (DFT) calculations and represents an interesting integration of modern techniques in stereoanalysis, which could contribute to the enhancement of theoretical protocols recently applied to solve stereochemical aspects in structure elucidation.


Mar Drugs


Marine drugs


Aiello A,Fattorusso E,Imperatore C,Luciano P,Menna M,Vitalone R




Has Abstract


2012-01-01 00:00:00












  • Phytoene Accumulation in the Novel Microalga Chlorococcum sp. Using the Pigment Synthesis Inhibitor Fluridone.

    abstract::Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Laje K,Seger M,Dungan B,Cooke P,Polle J,Holguin FO

    更新日期:2019-03-22 00:00:00

  • Study on the Antifibrotic Effects of Recombinant Shark Hepatical Stimulator Analogue (r-sHSA) in Vitro and in Vivo.

    abstract::Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang Y,Zhang X,Yang Y,Yang X,Ye B

    更新日期:2015-08-18 00:00:00

  • Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013.

    abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sheu JH,Chen YH,Chen YH,Su YD,Chang YC,Su JH,Weng CF,Lee CH,Fang LS,Wang WH,Wen ZH,Wu YC,Sung PJ

    更新日期:2014-04-10 00:00:00

  • Cytotoxicity of the ascidian Cystodytes dellechiajei against tumor cells and study of the involvement of associated microbiota in the production of cytotoxic compounds.

    abstract::Many cytotoxic compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Pyridoacridine alkaloids are the main compounds extracted from the ascidian Cystodytes dellechiajei. Here we describe the in vitro antiproliferative activity aga...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Martinez-García M,Diaz-Valdés M,Ramos-Esplá A,Salvador N,Lopez P,Larriba E,Antón J

    更新日期:2007-07-19 00:00:00

  • Astaxanthin Attenuates Fish Oil-Related Hepatotoxicity and Oxidative Insult in Juvenile Pacific White Shrimp (Litopenaeus vannamei).

    abstract::The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yu Y,Liu Y,Yin P,Zhou W,Tian L,Liu Y,Xu D,Niu J

    更新日期:2020-04-17 00:00:00

  • Chitosan based polyelectrolyte complexes as potential carrier materials in drug delivery systems.

    abstract::Chitosan has been the subject of interest for its use as a polymeric drug carrier material in dosage form design due to its appealing properties such as biocompatibility, biodegradability, low toxicity and relatively low production cost from abundant natural sources. However, one drawback of using this natural polysac...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Hamman JH

    更新日期:2010-04-19 00:00:00

  • Fishery Wastes as a Yet Undiscovered Treasure from the Sea: Biomolecules Sources, Extraction Methods and Valorization.

    abstract::The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Caruso G,Floris R,Serangeli C,Di Paola L

    更新日期:2020-12-07 00:00:00

  • Sinulolides A-H, new cyclopentenone and butenolide derivatives from soft coral Sinularia sp.

    abstract::Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were d...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yang B,Wei X,Huang J,Lin X,Liu J,Liao S,Wang J,Zhou X,Wang L,Liu Y

    更新日期:2014-10-23 00:00:00

  • Absorption and Transport of Sea Cucumber Saponins from Apostichopus japonicus.

    abstract::The present study is focused on the intestinal absorption of sea cucumber saponins. We determined the pharmacokinetic characteristics and bioavailability of Echinoside A and Holotoxin A₁; the findings indicated that the bioavailability of Holotoxin A₁ was lower than Echinoside A. We inferred that the differences in ch...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Li S,Wang Y,Jiang T,Wang H,Yang S,Lv Z

    更新日期:2016-06-17 00:00:00

  • New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum Asbestinum.

    abstract::Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gutiérrez M,Santamaría R,Gómez-Reyes JF,Guzmán HM,Ávila-Román J,Motilva V,Talero E

    更新日期:2020-01-27 00:00:00

  • Characterization of Properties and Transglycosylation Abilities of Recombinant α-Galactosidase from Cold-Adapted Marine Bacterium Pseudoalteromonas KMM 701 and Its C494N and D451A Mutants.

    abstract::A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

    更新日期:2018-09-24 00:00:00

  • Antiproliferative Scalarane-Based Metabolites from the Red Sea Sponge Hyrtios erectus.

    abstract::Two new sesterterpenes analogs, namely, 12-acetoxy,16-epi-hyrtiolide (1) and 12β-acetoxy,16β-methoxy,20α-hydroxy-17-scalaren-19,20-olide (2), containing a scalarane-based framework along with seven previously reported scalarane-type sesterterpenes (3-9) have been isolated from the sponge Hyrtios erectus (order Dictyoc...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Elhady SS,Al-Abd AM,El-Halawany AM,Alahdal AM,Hassanean HA,Ahmed SA

    更新日期:2016-07-08 00:00:00

  • Cephalopods as vectors of harmful algal bloom toxins in marine food webs.

    abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Lopes VM,Lopes AR,Costa P,Rosa R

    更新日期:2013-09-06 00:00:00

  • Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.

    abstract::There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Costantino V,Della Sala G,Saurav K,Teta R,Bar-Shalom R,Mangoni A,Steindler L

    更新日期:2017-02-28 00:00:00

  • Mucoadhesive microparticles for gastroretentive delivery: preparation, biodistribution and targeting evaluation.

    abstract::The aim of this research was to prepare and characterize alginate-chitosan mucoadhesive microparticles containing puerarin. The microparticles were prepared by an emulsification-internal gelatin method using a combination of chitosan and Ca2+ as cationic components and alginate as anions. Surface morphology, particle ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hou JY,Gao LN,Meng FY,Cui YL

    更新日期:2014-12-01 00:00:00

  • In vitro acylation of okadaic acid in the presence of various bivalves' extracts.

    abstract::The dinoflagellate Dinophysis spp. is responsible for diarrhetic shellfish poisoning (DSP). In the bivalves exposed to the toxic bloom of the dinoflagellate, dinophysistoxin 3 (DTX3), the 7-OH acylated form of either okadaic acid (OA) or DTX1, is produced. We demonstrated in vitro acylation of OA with palmitoyl CoA in...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Konoki K,Onoda T,Watanabe R,Cho Y,Kaga S,Suzuki T,Yotsu-Yamashita M

    更新日期:2013-01-29 00:00:00

  • Fucus vesiculosus and Ascophyllum nodosum Ameliorate Liver Function by Reducing Diet-Induced Steatosis in Rats.

    abstract::The Asian coastal communities have used the brown seaweeds Fucus vesiculosus and Ascophyllum nodosum since ancient times. Recently, some in vitro and in vivo studies have demonstrated their abilities in reducing risk factors for metabolic syndrome. Here, we analyzed the protective effect of a phytocomplex extracted fr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gabbia D,Saponaro M,Sarcognato S,Guido M,Ferri N,Carrara M,De Martin S

    更新日期:2020-01-17 00:00:00

  • Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity.

    abstract::Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Žula A,Będziak I,Kikelj D,Ilaš J

    更新日期:2018-10-27 00:00:00

  • Biological Activities of Rhamnan Sulfate Extract from the Green Algae Monostroma nitidum (Hitoegusa).

    abstract::Monostroma nitidum is a green single-cell layered algae that grows on the southwest coast of Japan. It is often used for salad ingredients, boiled tsukudani, soups, etc., due to its health benefits. M. nitidum is composed of many cell aggregates, and the various substances that fill the intercellular space are dietary...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Suzuki K,Terasawa M

    更新日期:2020-04-24 00:00:00

  • The carotenogenesis pathway via the isoprenoid-beta-carotene interference approach in a new strain of Dunaliella salina isolated from Baja California Mexico.

    abstract::D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Paniagua-Michel J,Capa-Robles W,Olmos-Soto J,Gutierrez-Millan LE

    更新日期:2009-01-01 00:00:00

  • Gageostatins A-C, antimicrobial linear lipopeptides from a marine Bacillus subtilis.

    abstract::Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Tareq FS,Lee MA,Lee HS,Lee JS,Lee YJ,Shin HJ

    更新日期:2014-01-31 00:00:00

  • A Transcriptomic Survey of Ion Channel-Based Conotoxins in the Chinese Tubular Cone Snail (Conus betulinus).

    abstract::Conotoxins in the venom of cone snails (Conus spp.) are a mixture of active peptides that work as blockers, agonists, antagonists, or inactivators of various ion channels. Recently we reported a high-throughput method to identify 215 conotoxin transcripts from the Chinese tubular cone snail, C. betulinus. Here, based ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Huang Y,Peng C,Yi Y,Gao B,Shi Q

    更新日期:2017-07-18 00:00:00

  • Pectenotoxin-2 from marine sponges: a potential anti-cancer agent-a review.

    abstract::Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Kim GY,Kim WJ,Choi YH

    更新日期:2011-01-01 00:00:00

  • Genome Sequence of Pseudomonas stutzeri 273 and Identification of the Exopolysaccharide EPS273 Biosynthesis Locus.

    abstract::Pseudomonas stutzeri 273 is a marine bacterium producing exopolysaccharide 273 (EPS273) with high anti-biofilm activity against P. aeruginosa PAO1. Here, the complete genome of P.stutzeri 273 was sequenced and the genome contained a circular 5.03 Mb chromosome. With extensive analysis of the genome, a genetic locus co...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wu S,Zheng R,Sha Z,Sun C

    更新日期:2017-07-10 00:00:00

  • Purification and characterization of a bifunctional alginate lyase from Pseudoalteromonas sp. SM0524.

    abstract::An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Li JW,Dong S,Song J,Li CB,Chen XL,Xie BB,Zhang YZ

    更新日期:2011-01-21 00:00:00

  • Polyhydroxylated steroids from the South China Sea soft coral Sarcophyton sp. and their cytotoxic and antiviral activities.

    abstract::Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Gong KK,Tang XL,Zhang G,Cheng CL,Zhang XW,Li PL,Li GQ

    更新日期:2013-12-02 00:00:00

  • Structure elucidation of new acetylated saponins, Lessoniosides A, B, C, D, and E, and non-acetylated saponins, Lessoniosides F and G, from the viscera of the sea cucumber Holothuria lessoni.

    abstract::Sea cucumbers produce numerous compounds with a wide range of chemical structural diversity. Among these, saponins are the most diverse and include sulfated, non-sulfated, acetylated and methylated congeners with different aglycone and sugar moieties. In this study, MALDI and ESI tandem mass spectrometry, in the posit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bahrami Y,Franco CM

    更新日期:2015-01-16 00:00:00

  • Design, synthesis and biological evaluation of tasiamide analogues as tumor inhibitors.

    abstract::Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhang W,Sun T,Ma Z,Li Y

    更新日期:2014-04-22 00:00:00

  • New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.

    abstract::A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lacret R,Oves-Costales D,Gómez C,Díaz C,de la Cruz M,Pérez-Victoria I,Vicente F,Genilloud O,Reyes F

    更新日期:2014-12-29 00:00:00

  • New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques.

    abstract::Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that functions as a master regulator of cellular growth and metabolism, in response to nutrient and hormonal stimuli. mTOR functions in two distinct complexes-mTORC1 is sensitive to rapamycin, while, mTORC2 is insensitive to this dr...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ruiz-Torres V,Losada-Echeberría M,Herranz-López M,Barrajón-Catalán E,Galiano V,Micol V,Encinar JA

    更新日期:2018-10-15 00:00:00