Aplisulfamines, new sulfoxide-containing metabolites from an aplidium tunicate: absolute stereochemistry at chiral sulfur and carbon atoms assigned through an original combination of spectroscopic and computational methods.

Abstract:

:Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute configuration at the three contiguous chiral centers present in the structures of both aplisulfamines, two at carbon and one at sulfur. This involved Electronic Circular Dichroism (ECD) studies, J-based configuration analysis and Density Functional Theory (DFT) calculations and represents an interesting integration of modern techniques in stereoanalysis, which could contribute to the enhancement of theoretical protocols recently applied to solve stereochemical aspects in structure elucidation.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Aiello A,Fattorusso E,Imperatore C,Luciano P,Menna M,Vitalone R

doi

10.3390/md10010051

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

51-63

issue

1

issn

1660-3397

pii

marinedrugs-10-00051

journal_volume

10

pub_type

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