Abstract：
:Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute configuration at the three contiguous chiral centers present in the structures of both aplisulfamines, two at carbon and one at sulfur. This involved Electronic Circular Dichroism (ECD) studies, J-based configuration analysis and Density Functional Theory (DFT) calculations and represents an interesting integration of modern techniques in stereoanalysis, which could contribute to the enhancement of theoretical protocols recently applied to solve stereochemical aspects in structure elucidation.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Aiello A,Fattorusso E,Imperatore C,Luciano P,Menna M,Vitalone Rdoi
10.3390/md10010051subject
Has Abstractpub_date
2012-01-01 00:00:00pages
51-63issue
1issn
1660-3397pii
marinedrugs-10-00051journal_volume
10pub_type
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