Abstract:
:Two previously unreported citrinin dimer derivatives, penicitol D (1) and 1-epi-citrinin H1 (2), were isolated from the culture of a deep sea-derived fungus Penicillium citrinum NLG-S01-P1, together with 11 biogenetic related compounds (3⁻13). A plausible biogenetic pathway for compounds 2⁻4 was proposed. Their structures, including absolute configurations, were established through analysis of extensive spectroscopic data and time-dependent density functional theory (TD-DFT) ECD calculations. Compounds 1 and 2 showed antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA). Compounds 5 and 10 displayed relatively stronger activities than the other compounds against Vibrio vulnificus and Vibrio campbellii. Compound 1 showed the most potent cytotoxic activity towards the HeLa cell.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Wang W,Liao Y,Zhang B,Gao M,Ke W,Li F,Shao Zdoi
10.3390/md17010046subject
Has Abstractpub_date
2019-01-10 00:00:00issue
1issn
1660-3397pii
md17010046journal_volume
17pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18030133
更新日期:2020-02-26 00:00:00
abstract::The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16090342
更新日期:2018-09-19 00:00:00
abstract::Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060347
更新日期:2019-06-11 00:00:00
abstract::Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12020871
更新日期:2014-01-31 00:00:00
abstract::The herein presented complete structure of the core oligosaccharide of lipopolysaccharide (LPS) P. shigelloides Polish Collection of Microorganisms (PCM) 2231 (serotype O17) was investigated by (1)H, (13)C NMR spectroscopy, mass spectrometry, chemical analyses and serological methods. The core oligosaccharide is compo...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11020440
更新日期:2013-02-06 00:00:00
abstract::Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100564
更新日期:2019-09-30 00:00:00
abstract::The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13095947
更新日期:2015-09-18 00:00:00
abstract::Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ec...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md17060320
更新日期:2019-05-30 00:00:00
abstract::Intermittent hypobaric hypoxia (IH) is linked with oxidative stress, impairing cardiac function. However, early IH also activate cardio-protective mechanisms. Omega 3 fatty acids (Ω3) induce cardioprotection by reducing infarct size and reinforcing antioxidant defenses. The aim of this work was to determine the combin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020838
更新日期:2015-02-04 00:00:00
abstract::To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16080263
更新日期:2018-08-01 00:00:00
abstract::Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17100586
更新日期:2019-10-16 00:00:00
abstract::Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050299
更新日期:2019-05-20 00:00:00
abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10030639
更新日期:2012-03-01 00:00:00
abstract::In the course of our continuing efforts to identify bioactive secondary metabolites from Red Sea marine invertebrates, we have investigated the sponge Hemimycale arabica. The antimicrobial fraction of an organic extract of the sponge afforded two new hydantoin alkaloids, hemimycalins A and B (2 and 3), together with t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13116609
更新日期:2015-10-28 00:00:00
abstract::D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md7010045
更新日期:2009-01-01 00:00:00
abstract::Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10112596
更新日期:2012-11-21 00:00:00
abstract::Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structure...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18090454
更新日期:2020-08-30 00:00:00
abstract::Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110631
更新日期:2019-11-06 00:00:00
abstract::Using theonellasterol as a novel FXR antagonist hit, we prepared a series of semi-synthetic derivatives in order to gain insight into the structural requirements for exhibiting antagonistic activity. These derivatives are characterized by modification at the exocyclic carbon-carbon double bond at C-4 and at the hydrox...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10112448
更新日期:2012-11-05 00:00:00
abstract::An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11010099
更新日期:2013-01-10 00:00:00
abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031185
更新日期:2014-03-06 00:00:00
abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120377
更新日期:2017-12-04 00:00:00
abstract::The first total synthesis of the marine nucleoside Mycalisine B-a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside-has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the a...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17040226
更新日期:2019-04-14 00:00:00
abstract::The carbonic anhydrase (CA, EC 4.2.1.1) superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090270
更新日期:2017-08-28 00:00:00
abstract::Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19010008
更新日期:2020-12-27 00:00:00
abstract::Two new diphenyl ethers (1 and 2) and four new phenolic bisabolane sesquiterpenoids (3⁻6), together with five known related derivatives, were isolated from the culture of the endophytic fungus Aspergillus flavus QQSG-3 obtained from a fresh branch of Kandelia obobata, which was collected from Huizhou city in the provi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16090307
更新日期:2018-09-01 00:00:00
abstract::Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040101
更新日期:2018-03-23 00:00:00
abstract::The main challenges facing efforts to prevent the transmission of human immunodeficiency virus (HIV) are the lack of access to sexual education services and sexual violence against young women and girls. Vaginal formulations for the prevention of sexually transmitted infections are currently gaining importance in drug...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15020050
更新日期:2017-02-21 00:00:00
abstract::Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11093297
更新日期:2013-08-28 00:00:00
abstract::Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 w...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15020043
更新日期:2017-02-17 00:00:00