Core oligosaccharide of Plesiomonas shigelloides PCM 2231 (Serotype O17) lipopolysaccharide--structural and serological analysis.

abstract：:In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the cultur...

journal_title：Marine drugs

authors： Wu DL,Li HJ,Smith DR,Jaratsittisin J,Xia-Ke-Er XF,Ma WZ,Guo YW,Dong J,Shen J,Yang DP,Lan WJ

更新日期：2018-07-06 00:00:00

abstract：:A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands (a commonwealth of the USA), led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A (1). Laucysteinamide A is a new monomeric analogue o...

journal_title：Marine drugs

authors： Zhang C,Naman CB,Engene N,Gerwick WH

更新日期：2017-04-14 00:00:00

abstract：:The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...

journal_title：Marine drugs

authors： Miyaoka R,Hosokawa M,Ando M,Mori T,Hamaguchi HO,Takeyama H

更新日期：2014-05-13 00:00:00

abstract：:Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...

journal_title：Marine drugs

authors： Twiner MJ,Rehmann N,Hess P,Doucette GJ

更新日期：2008-05-07 00:00:00

abstract：:The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...

journal_title：Marine drugs

authors： Caruso G,Floris R,Serangeli C,Di Paola L

更新日期：2020-12-07 00:00:00

abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...

journal_title：Marine drugs

authors： Jøraholmen MW,Bhargava A,Julin K,Johannessen M,Škalko-Basnet N

更新日期：2020-01-31 00:00:00

abstract：:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation t...

journal_title：Marine drugs

authors： Kim MW,Niidome T,Lee R

更新日期：2019-10-12 00:00:00

abstract：:Chitosan is the N-deacetylated derivative of chitin, a naturally abundant mucopolysaccharide that consists of 2-acetamido-2-deoxy-β-d-glucose through a β (1→4) linkage and is found in nature as the supporting material of crustaceans, insects, etc. Chitosan has been strongly recommended as a suitable functional materia...

journal_title：Marine drugs

authors： Aranaz I,Gutiérrez MC,Ferrer ML,del Monte F

更新日期：2014-11-24 00:00:00

abstract：:Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...

journal_title：Marine drugs

authors： Kim GY,Kim WJ,Choi YH

更新日期：2011-01-01 00:00:00

abstract：:AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 reverse transcriptase (RT) inhibitory activity, such as the diterpenes...

journal_title：Marine drugs

authors： Miceli LA,Teixeira VL,Castro HC,Rodrigues CR,Mello JF,Albuquerque MG,Cabral LM,de Brito MA,de Souza AM

更新日期：2013-10-29 00:00:00

abstract：:Marine sponges belonging to the phylum Porifera (Metazoa), evolutionarily the oldest animals are the single best source of marine natural products. The present review presents a comprehensive overview of the source, taxonomy, country of origin or geographical position, chemical class, and biological activity of sponge...

journal_title：Marine drugs

authors： Mehbub MF,Lei J,Franco C,Zhang W

更新日期：2014-08-19 00:00:00

abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...

journal_title：Marine drugs

authors： Daraghmeh N,Chowdhry BZ,Leharne SA,Al Omari MM,Badwan AA

更新日期：2015-03-30 00:00:00

abstract：:We have searched for special characteristics in growth, protein expression, fatty acids and volatile organic compounds (VOCs) in a local Phaeodactylum tricornutum Bohlin strain (Bergen Marine Biobank), by comparing it with a common accession strain (CCAP). Differences in growth and expressed proteins were detected bet...

journal_title：Marine drugs

authors： Prestegard SK,Erga SR,Steinrücken P,Mjøs SA,Knutsen G,Rohloff J

更新日期：2015-12-30 00:00:00

abstract：:β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...

journal_title：Marine drugs

authors： Lage S,Annadotter H,Rasmussen U,Rydberg S

更新日期：2015-03-02 00:00:00

abstract：:In the current study, hemostatic compositions including a combination of chitosan and kaolin have been developed. Chitosan is a marine polysaccharide derived from chitins, a structural component in the shells of crustaceans. Both chitosan and kaolin have the ability to mediate a quick and efficient hemostatic effect f...

journal_title：Marine drugs

authors： Elsabahy M,Hamad MA

更新日期：2021-01-22 00:00:00

abstract：:Marine biotoxin-contaminated seafood has caused thousands of poisonings worldwide this century. Given these threats, there is an increasing need for improved technologies that can be easily integrated into coastal monitoring programs. This study evaluates approaches for monitoring toxins associated with recurrent toxi...

journal_title：Marine drugs

authors： Hattenrath-Lehmann TK,Lusty MW,Wallace RB,Haynes B,Wang Z,Broadwater M,Deeds JR,Morton SL,Hastback W,Porter L,Chytalo K,Gobler CJ

更新日期：2018-01-13 00:00:00

abstract：:The effect of gold nanoparticles (GNPs) synthesized in marine algae has been described in the context of skin, where they have shown potential benefit. Ecklonia stolonifera (ES) is a brown algae that belongs to the Laminariaceae family, and is widely used as a component of food and medicine due to its biological activ...

journal_title：Marine drugs

authors： Jun ES,Kim YJ,Kim HH,Park SY

更新日期：2020-08-19 00:00:00

abstract：:An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...

journal_title：Marine drugs

authors： Lee HP,Huang SY,Lin YY,Wang HM,Jean YH,Wu SF,Duh CY,Wen ZH

更新日期：2013-01-10 00:00:00

abstract：:Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...

journal_title：Marine drugs

authors： Getachew AT,Jacobsen C,Holdt SL

更新日期：2020-07-27 00:00:00

abstract：:Chemical investigation on the soft coral Sarcophyton sp. collected from the South China Sea yielded three new polyhydroxylated steroids, compounds (1-3), together with seven known ones (4-10). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related kn...

journal_title：Marine drugs

authors： Gong KK,Tang XL,Zhang G,Cheng CL,Zhang XW,Li PL,Li GQ

更新日期：2013-12-02 00:00:00

abstract：:Nanofibrous structures mimicking the native extracellular matrix have attracted considerable attention for biomedical applications. The present study aims to design and produce drug-eluting core-shell fibrous scaffolds for wound healing and skin tissue engineering. Aloe vera extracts were encapsulated inside polymer f...

journal_title：Marine drugs

authors： Zahedi E,Esmaeili A,Eslahi N,Shokrgozar MA,Simchi A

更新日期：2019-01-05 00:00:00

abstract：:Cyclic imines are lipophilic marine toxins that bioaccumulate in seafood. Their structure comprises a cyclic-imino moiety, responsible for acute neurotoxicity in mice. Cyclic imines have not been linked yet to human poisonings and are not regulated in Europe, although the European Food Safety Authority requires more d...

journal_title：Marine drugs

authors： García-Altares M,Casanova A,Bane V,Diogène J,Furey A,de la Iglesia P

更新日期：2014-06-23 00:00:00

abstract：:Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...

journal_title：Marine drugs

authors： Ngokpol S,Suwakulsiri W,Sureram S,Lirdprapamongkol K,Aree T,Wiyakrutta S,Mahidol C,Ruchirawat S,Kittakoop P

更新日期：2015-06-05 00:00:00

abstract：:The red seaweeds belonging to the genus Laurencia are well known as halogenated secondary metabolites producers, mainly terpenoids and acetogennins. Several of these chemicals exhibit important ecological roles and biotechnological applications. However, knowledge regarding the genes involved in the biosynthesis of th...

journal_title：Marine drugs

authors： de Oliveira LS,Tschoeke DA,de Oliveira AS,Hill LJ,Paradas WC,Salgado LT,Thompson CC,Pereira RC,Thompson FL

更新日期：2015-02-10 00:00:00

abstract：:Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...

journal_title：Marine drugs

authors： Wang X,Schröder HC,Feng Q,Draenert F,Müller WE

更新日期：2013-03-08 00:00:00

abstract：:This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...

journal_title：Marine drugs

authors： Boucle S,Melin C,Clastre M,Guillard J

更新日期：2015-01-19 00:00:00

abstract：:Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...

journal_title：Marine drugs

authors： Anisimova N,Ustyuzhanina N,Bilan M,Donenko F,Usov A,Kiselevskiy M,Nifantiev N

更新日期：2017-09-30 00:00:00

abstract：:The goal of this work was to identify sequences encoding monooxygenase biocatalysts with novel features by in silico mining an assembled metagenomic dataset of polar and subpolar marine sediments. The targeted enzyme sequences were Baeyer-Villiger and bacterial cytochrome P450 monooxygenases (CYP153). These enzymes ha...

journal_title：Marine drugs

authors： Musumeci MA,Lozada M,Rial DV,Mac Cormack WP,Jansson JK,Sjöling S,Carroll J,Dionisi HM

更新日期：2017-04-09 00:00:00

abstract：:To investigate a high cholesterol diet in Alzheimer's disease (AD) mice, they were fed with (2% cholesterol) in five groups with a control group, AD mice group, AD mice plus Meretrix lusoria group, AD mice plus Geloina eros group, and, AD mice plus Corbicula fluminea group for three months, and treated with the fatty ...

journal_title：Marine drugs

authors： Hsieh YL,Teng HJ,Yeh YH,Hsieh CH,Huang CY

更新日期：2018-08-01 00:00:00

abstract：:Marine organisms produce secondary metabolites that may be valuable for the development of novel drug leads as such and can also provide structural scaffolds for the design and synthesis of novel bioactive compounds. The marine alkaloids, clathrodin and oroidin, which were originally isolated from sponges of the genus...

journal_title：Marine drugs

authors： Zidar N,Montalvão S,Hodnik Ž,Nawrot DA,Žula A,Ilaš J,Kikelj D,Tammela P,Mašič LP

更新日期：2014-02-14 00:00:00