Abstract：
:Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic epileptic syndrome in California sea lions through investigation of a series of domoic acid poisoning cases between 1998 and 2006. The sea lion study provided a breadth of insight into clinical presentations, unusual behaviors, brain pathology, and epidemiology. A rat model that replicates key observations of the chronic epileptic syndrome in sea lions has been applied to identify the progression of the epileptic disease state, its relationship to behavioral manifestations, and to define the neural systems involved in these behavioral disorders. Here, we present the concept of domoic acid epileptic disease as a delayed manifestation of domoic acid poisoning and review the state of knowledge for this disease state in affected humans and sea lions. We discuss causative mechanisms and neural underpinnings of disease maturation revealed by the rat model to present the concept for olfactory origin of an epileptic disease; triggered in dendodendritic synapases of the olfactory bulb and maturing in the olfactory cortex. We conclude with updated information on populations at risk, medical diagnosis, treatment, and prognosis.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Ramsdell JS,Gulland FMdoi
10.3390/md12031185subject
Has Abstractpub_date
2014-03-06 00:00:00pages
1185-207issue
3issn
1660-3397pii
md12031185journal_volume
12pub_type
杂志文章,评审相关文献
Marine Drugs文献大全abstract：:The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, w...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110438
更新日期：2018-11-08 00:00:00
abstract：:Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110639
更新日期：2019-11-13 00:00:00
abstract：:Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110342
更新日期：2017-11-01 00:00:00
abstract：:Shrimp is one of the most popular seafoods worldwide, and its lipids have been studied for biological activity in both, muscle and exoskeleton. Free fatty acids, triglycerides, carotenoids, and other lipids integrate this fraction, and some of these compounds have been reported with cancer chemopreventive activities. ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11103926
更新日期：2013-10-16 00:00:00
abstract：:The red macroalga Agarophyton chilensis is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related A. vermiculophyllum. This indicates that the related two algae would have different enzyme systems or substrate composition. ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020096
更新日期：2019-02-02 00:00:00
abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020096
更新日期：2020-01-31 00:00:00
abstract：:Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020084
更新日期：2020-01-27 00:00:00
abstract：:Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable anti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040117
更新日期：2018-04-05 00:00:00
abstract：:Tetracenomycin X (Tcm X) has been reported to have antitumour activity in various cancers, but there have not been any studies on its activity with respect to lung cancer to date. Therefore, this study aims to investigate the anti-lung cancer activity of Tcm X. In this study, we found that tetracenomycin X showed anti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010063
更新日期：2019-01-18 00:00:00
abstract：:The dinoflagellate Prorocentrum belizeanum is responsible for the production of several toxins involved in the red tide phenomenon known as Diarrhetic Shellfish Poisoning (DSP). In this paper we report on the biosynthetic origin of an okadaic acid water-soluble ester derivative, DTX5c, on the basis of the spectroscopi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10102234
更新日期：2012-10-01 00:00:00
abstract：:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100581
更新日期：2019-10-12 00:00:00
abstract：:Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific abe...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9091580
更新日期：2011-01-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) are not only cytotoxic towards host pathogens or cancer cells but also are able to act as immunomodulators. It was shown that some human and non-human AMPs can interact with complement proteins and thereby modulate complement activity. Thus, AMPs could be considered as the base for comple...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18120631
更新日期：2020-12-10 00:00:00
abstract：:Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chito...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17080452
更新日期：2019-08-01 00:00:00
abstract：:This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h....
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040226
更新日期：2020-04-24 00:00:00
abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100564
更新日期：2019-09-30 00:00:00
abstract：:Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15110354
更新日期：2017-11-10 00:00:00
abstract：:Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md20080004
更新日期：2008-05-07 00:00:00
abstract：:Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod Temora longicornis. Production of DMS can rapidly increase following ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11072486
更新日期：2013-07-15 00:00:00
abstract：:Mycosporine-like amino acids (MAAs) have gained considerable attention as highly active photoprotective candidates for human sunscreens. However, more studies are necessary to evaluate the extraction efficiency of these metabolites in solvents compatible with cosmetics and their subsequent analysis by HPLC. In the pre...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18010027
更新日期：2019-12-28 00:00:00
abstract：:α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16060215
更新日期：2018-06-20 00:00:00
abstract：:Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040190
更新日期：2020-04-02 00:00:00
abstract：:The democratization of sequencing technologies fostered a leap in our knowledge of the diversity of marine phytoplanktonic microalgae, revealing many previously unknown species and lineages. The evolutionary history of the diversification of microalgae can be inferred from the analysis of their genome sequences. Howev...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020078
更新日期：2020-01-25 00:00:00
abstract：:Like many fields of the biosciences, actinomycete natural products research has been revolutionised by next-generation DNA sequencing (NGS). Hundreds of new genome sequences from actinobacteria are made public every year, many of them as a result of projects aimed at identifying new natural products and their biosynth...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14040078
更新日期：2016-04-13 00:00:00
abstract：:Chemical investigation of the marine soft coral Sarcophyton tenuispiculatum resulted in the isolation of a 1,4-dihydrobenzoquinone, sarcotenuhydroquinone (1), three new cembranoids, sarcotenusenes A‒C (2‒4), and ten previously reported metabolites 5-14. The chemical structures of all isolated metabolites were determin...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19010008
更新日期：2020-12-27 00:00:00
abstract：:The marine environment is host to unparalleled biological and chemical diversity, making it an attractive resource for the discovery of new therapeutics for a plethora of diseases. Compounds that are extracted from cyanobacteria are of special interest due to their unique structural scaffolds and capacity to produce p...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14010017
更新日期：2016-01-12 00:00:00
abstract：:Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10010051
更新日期：2012-01-01 00:00:00
abstract：:After in situ incubation at the site for a year, phytoplanktons in surface water were exposed to natural light in temperate lakes (every month); thereafter, the net production rate of photoprotective compounds (mycosporine-like amino acids, MAAs) was calculated using (13)C labeled tracer. This is the first report desc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13116740
更新日期：2015-11-06 00:00:00
abstract：:An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9010109
更新日期：2011-01-21 00:00:00
abstract：:Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100372
更新日期：2018-10-09 00:00:00
