Abstract：
:Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and D-galactose (D-gal)-induced aging in a murine model. Results indicated that PPC inhibits the production of the inflammatory cytokines TNF-α and IL-6, and the inflammatory mediator nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. It also protected mice from D-gal induced informatory aging by increasing the activity of the antioxidant enzyme, such as superoxide dismutase (SOD), inhibiting D-gal-induced NF-κB upregulation, and increasing PPARs expression in the brain and gut. The findings indicated that PPC has favorable anti-inflammatory and anti-aging properties, and could be useful in the treatment of acute inflammation and senescence diseases.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Zhang R,Chen J,Mao X,Qi P,Zhang Xdoi
10.3390/md17100586subject
Has Abstractpub_date
2019-10-16 00:00:00issue
10issn
1660-3397pii
md17100586journal_volume
17pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:This study describes the preparation, characterization and performance of a novel excipient for use in oro-dispersible tablets (ODT). The excipient (Cop-CM) consists of chitin and mannitol. The excipient with optimal physicochemical properties was obtained at a chitin: mannitol ratio of 2:8 (w/w) and produced by roll ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13041739
更新日期：2015-03-30 00:00:00
abstract：BACKGROUND:Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phas...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030074
更新日期：2017-03-15 00:00:00
abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18080419
更新日期：2020-08-10 00:00:00
abstract：:A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglyc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13084934
更新日期：2015-08-06 00:00:00
abstract：:A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora of many TTX-bearing hosts, thereby providing strong support for ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030177
更新日期：2020-03-23 00:00:00
abstract：:Microalgae represent a source of bio-active compounds such as carotenoids with potent anti-inflammatory and antioxidant properties. We aimed to investigate the effects of fucoxanthin (FX) in both in vitro and in vivo skin models. Firstly, its anti-inflammatory activity was evaluated in LPS-stimulated THP-1 macrophages...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100378
更新日期：2018-10-10 00:00:00
abstract：:Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13116687
更新日期：2015-10-30 00:00:00
abstract：:Anemonia viridis is a widespread and extensively studied Mediterranean species of sea anemone from which a large number of polypeptide toxins, such as blood depressing substances (BDS) peptides, have been isolated. The first members of this class, BDS-1 and BDS-2, are polypeptides belonging to the β-defensin fold fami...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11114213
更新日期：2013-10-30 00:00:00
abstract：:Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15110342
更新日期：2017-11-01 00:00:00
abstract：:High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030148
更新日期：2020-03-04 00:00:00
abstract：:The goal of this work was to identify sequences encoding monooxygenase biocatalysts with novel features by in silico mining an assembled metagenomic dataset of polar and subpolar marine sediments. The targeted enzyme sequences were Baeyer-Villiger and bacterial cytochrome P450 monooxygenases (CYP153). These enzymes ha...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15040114
更新日期：2017-04-09 00:00:00
abstract：:Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100372
更新日期：2018-10-09 00:00:00
abstract：:Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16010018
更新日期：2018-01-09 00:00:00
abstract：:The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030153
更新日期：2019-03-05 00:00:00
abstract：:Cyanobacteria are photosynthetic microorganisms that colonize diverse environments worldwide, ranging from ocean to freshwaters, soils, and extreme environments. Their adaptation capacities and the diversity of natural products that they synthesize, support cyanobacterial success in colonization of their respective ec...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17060320
更新日期：2019-05-30 00:00:00
abstract：:Ten new di-, tri- and tetrasulfated triterpene glycosides, psolusosides B1 (1), B2 (2), J (3), K (4), L (5), M (6), N (7), O (8), P (9), and Q (10), were isolated from the sea cucumber Psolus fabricii collected in the Sea of Okhotsk near the Kurile Islands. Structures of these glycosides were established by two-dimens...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17110631
更新日期：2019-11-06 00:00:00
abstract：:Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13095784
更新日期：2015-09-15 00:00:00
abstract：:Ovarian cancer is one of the prevalent gynecological cancers occurring in women. In particular, the efficiency of standard therapeutic methods decreases when recurrence and chemoresistance ensue. To assist standard anti-cancer agents in the cure of ovarian cancer, development and application of new compounds such as s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060331
更新日期：2019-06-03 00:00:00
abstract：:In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11030611
更新日期：2013-02-26 00:00:00
abstract：:Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19020067
更新日期：2021-01-27 00:00:00
abstract：:Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16070218
更新日期：2018-06-25 00:00:00
abstract：:Many cytotoxic compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Pyridoacridine alkaloids are the main compounds extracted from the ascidian Cystodytes dellechiajei. Here we describe the in vitro antiproliferative activity aga...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md503052
更新日期：2007-07-19 00:00:00
abstract：:This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13010655
更新日期：2015-01-19 00:00:00
abstract：:Drug-resistant Staphylococcus aureus is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple S. aureus strains, including current drug-resistant ones, are needed. Previously, we have described...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10051103
更新日期：2012-05-01 00:00:00
abstract：:Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030138
更新日期：2019-02-27 00:00:00
abstract：:The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13052924
更新日期：2015-05-13 00:00:00
abstract：:The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17100543
更新日期：2019-09-21 00:00:00
abstract：:The first total synthesis of the marine nucleoside Mycalisine B-a naturally occurring and structurally distinct 4,5-unsaturated 7-deazapurine nucleoside-has been accomplished in 10 linear steps with 27.5% overall yield from commercially available 1,2,3,5-tetra-O-acetyl-ribose and tetracyanoethylene. Key steps of the a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17040226
更新日期：2019-04-14 00:00:00
abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12010069
更新日期：2013-12-24 00:00:00
abstract：:Natural phenolic compounds are important classes of plant, microorganism, and algal secondary metabolites. They have well-documented beneficial biological activities. The marine environment is less explored than other environments but have huge potential for the discovery of new unique compounds with potential applica...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18080389
更新日期：2020-07-27 00:00:00
