Abstract：
:An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented anti-inflammatory and anti-nociceptive properties. In the present study, we attempt to examine the therapeutic effects of lemnalol on intra-articular monosodium urate (MSU)-induced gouty arthritis in rats. In the present study, we found that treatment with lemnalol (intramuscular [im]), but not colchicine (oral [po]), significantly attenuated MUS-induced mechanical allodynia, paw edema and knee swelling. Histomorphometric and immunohistochemistry analysis revealed that MSU-induced inflammatory cell infiltration, as well as the elevated expression of c-Fos and pro-inflammatory proteins (inducible nitric oxide synthase and cyclooxygenase-2) observed in synovial tissue, were significantly inhibited by treatment with lemnalol. We conclude that lemnalol may be a promising candidate for the development of a new treatment for gout and other acute neutrophil-driven inflammatory diseases.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Lee HP,Huang SY,Lin YY,Wang HM,Jean YH,Wu SF,Duh CY,Wen ZHdoi
10.3390/md11010099subject
Has Abstractpub_date
2013-01-10 00:00:00pages
99-113issue
1issn
1660-3397pii
md11010099journal_volume
11pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050149
更新日期：2018-05-01 00:00:00
abstract：:Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18120594
更新日期：2020-11-26 00:00:00
abstract：:This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h....
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040226
更新日期：2020-04-24 00:00:00
abstract：:An alginate lyase-producing bacterial strain, Pseudoalteromonas sp. SM0524, was screened from marine rotten kelp. In an optimized condition, the production of alginate lyase from Pseudoalteromonas sp. SM0524 reached 62.6 U/mL, suggesting that strain SM0524 is a good producer of alginate lyases. The bifunctional algina...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9010109
更新日期：2011-01-21 00:00:00
abstract：:Isolation of marine compounds from living invertebrates represents a major challenge for sustainable and environmentally friendly exploitation of marine bio-resources. To develop innovative technology to trap invertebrate compounds in the open sea, the proof of concept of a system combining external continuous circula...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050152
更新日期：2018-05-06 00:00:00
abstract：:Cyclic imines are lipophilic marine toxins that bioaccumulate in seafood. Their structure comprises a cyclic-imino moiety, responsible for acute neurotoxicity in mice. Cyclic imines have not been linked yet to human poisonings and are not regulated in Europe, although the European Food Safety Authority requires more d...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063706
更新日期：2014-06-23 00:00:00
abstract：:Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone dea...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md16050175
更新日期：2018-05-22 00:00:00
abstract：:Ice-binding protein (IBPs) protect cells from cryo-injury during cryopreservation by inhibiting ice recrystallization (IR), which is a main cause of cell death. In the present study, we employed two IBPs, one, designated LeIBP from Arctic yeast, and the other, designated FfIBP from Antarctic sea ice bacterium, in the ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120372
更新日期：2017-12-01 00:00:00
abstract：:In this study, Spirulina maxima derived pectin nanoparticles (SmPNPs) were synthesized and multiple biological effects were investigated using in vitro and in vivo models. SmPNPs were not toxic to Raw 264.7 cells and zebrafish embryos up to 1 mg/mL and 200 µg/mL, respectively. SmPNPs upregulated Il 10, Cat, Sod 2, Def...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18110556
更新日期：2020-11-07 00:00:00
abstract：:The red macroalga Agarophyton chilensis is a well-known producer of eicosanoids such as hydroxyeicosatetraenoic acids, but the alga produces almost no prostaglandins, unlike the closely related A. vermiculophyllum. This indicates that the related two algae would have different enzyme systems or substrate composition. ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020096
更新日期：2019-02-02 00:00:00
abstract：:We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15090279
更新日期：2017-09-01 00:00:00
abstract：:Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15080260
更新日期：2017-08-19 00:00:00
abstract：:Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12041876
更新日期：2014-03-28 00:00:00
abstract：:Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12020871
更新日期：2014-01-31 00:00:00
abstract：:Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11093381
更新日期：2013-09-06 00:00:00
abstract：:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12115503
更新日期：2014-11-19 00:00:00
abstract：:The mucus produced by many marine organisms is a complex mixture of proteins and polysaccharides forming a weak watery gel. It is essential for vital processes including locomotion, navigation, structural support, heterotrophic feeding and defence against a multitude of environmental stresses, predators, parasites, an...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13085276
更新日期：2015-08-19 00:00:00
abstract：:Aurantiochytrium limacinum, a marine heterotrophic protist/microalga has shown interesting yields of docosahexaenoic acid (DHA) when cultured with different carbon sources: glucose, pure and crude glycerol. A complete study in a lab-scale fermenter allowed for the characterization and comparison of the growth kinetic ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13127064
更新日期：2015-12-05 00:00:00
abstract：:Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16030093
更新日期：2018-03-13 00:00:00
abstract：:There are numerous biologically active substances with novel structures and unique physiological functions in marine organisms. These substances are important sources of new lead compounds. Pelorol is a natural product isolated from marine organisms that possesses a novel structure with high bioactivity. In this paper...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14060118
更新日期：2016-06-21 00:00:00
abstract：:The total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lau...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11072382
更新日期：2013-07-08 00:00:00
abstract：:Marine natural products are a source of promising agents for cancer treatment. However, there is a need to improve the evaluation of their mechanism of action in tumors. Metabolomics of the response to anti-tumor agents is a tool to reveal candidate biomarkers and metabolic targets. We used two-dimensional high-resolu...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11103846
更新日期：2013-10-11 00:00:00
abstract：:The carbonic anhydrase (CA, EC 4.2.1.1) superfamily of metalloenzymes catalyzes the hydration of carbon dioxide to bicarbonate and protons. The catalytically active form of these enzymes incorporates a metal hydroxide derivative, the formation of which is the rate-determining step of catalytic reaction, being affected...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15090270
更新日期：2017-08-28 00:00:00
abstract：:The geographic position, highly fluctuating sea temperatures and hypersalinity make Persian Gulf an extreme environment. Although this unique environment has high biodiversity dominated by invertebrates, its potential in marine biodiscovery has largely remained untapped. Herein, we aimed at a detailed analysis of the ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18070366
更新日期：2020-07-16 00:00:00
abstract：:In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacter...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9030294
更新日期：2011-02-25 00:00:00
abstract：:Ecklonia cava (E. cava) can alleviate vascular dysfunction in diseases associated with poor circulation. E. cava contains various polyphenols with different functions, but few studies have compared the effects of these polyphenols. Here, we comparatively investigated four major compounds present in an ethanoic extract...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110441
更新日期：2018-11-09 00:00:00
abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100349
更新日期：2018-09-24 00:00:00
abstract：:Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11093297
更新日期：2013-08-28 00:00:00
abstract：:A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020084
更新日期：2019-02-01 00:00:00
abstract：:The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title：Marine drugs
pub_type： 杂志文章,已发布勘误
doi：10.3390/md15090292
更新日期：2017-09-20 00:00:00
