Abstract：
:Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the search for new preventive and treatment strategies. Improved comprehension of T2DM pathophysiology provided various new agents and approaches against T2DM including via nutritional and lifestyle interventions. Seaweeds are rich in dietary fibres, unsaturated fatty acids, and polyphenolic compounds. Many of these seaweed compositions have been reported to be beneficial to human health including in managing diabetes. In this review, we discussed the diversity of seaweed composition and bioactive compounds which are potentially useful in preventing or managing T2DM by targeting various pharmacologically relevant routes including inhibition of enzymes such as α-glucosidase, α-amylase, lipase, aldose reductase, protein tyrosine phosphatase 1B (PTP1B) and dipeptidyl-peptidase-4 (DPP-4). Other mechanisms of action identified, such as anti-inflammatory, induction of hepatic antioxidant enzymes' activities, stimulation of glucose transport and incretin hormones release, as well as β-cell cytoprotection, were also discussed by taking into consideration numerous in vitro, in vivo, and human studies involving seaweed and seaweed-derived agents.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Sharifuddin Y,Chin YX,Lim PE,Phang SMdoi
10.3390/md13085447subject
Has Abstractpub_date
2015-08-21 00:00:00pages
5447-91issue
8issn
1660-3397pii
md13085447journal_volume
13pub_type
杂志文章,评审相关文献
Marine Drugs文献大全abstract：:Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16030076
更新日期：2018-02-28 00:00:00
abstract：:Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fr...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8020359
更新日期：2010-02-23 00:00:00
abstract：:Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12031471
更新日期：2014-03-13 00:00:00
abstract：:Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in water, but upon interaction with lipid bilayers, they oligomerize to form a po...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13041647
更新日期：2015-03-25 00:00:00
abstract：:Nine new sulfated triterpene glycosides, magnumosides A₁ (1), A₂ (2), A₃ (3), A₄ (4), B₁ (5), B₂ (6), C₁ (7), C₂ (8) and C₄ (9) as well as a known colochiroside B₂ (10) have been isolated from the tropical Indo-West Pacific sea cucumber Neothynidium (=Massinium) magnum (Phyllophoridae, Dendrochirotida) collected in th...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15080256
更新日期：2017-08-16 00:00:00
abstract：:High seafood consumption has traditionally been linked to a reduced risk of cardiovascular diseases, mainly due to the lipid lowering effects of the long chained omega 3 fatty acids. However, fish and seafood are also excellent sources of good quality proteins and emerging documentation show that, upon digestion, thes...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14110211
更新日期：2016-11-18 00:00:00
abstract：:Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11030718
更新日期：2013-03-08 00:00:00
abstract：:Many cytotoxic compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Pyridoacridine alkaloids are the main compounds extracted from the ascidian Cystodytes dellechiajei. Here we describe the in vitro antiproliferative activity aga...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md503052
更新日期：2007-07-19 00:00:00
abstract：:Two new cyclotetrapeptides, sartoryglabramides A (5) and B (6), and a new analog of fellutanine A (8) were isolated, together with six known compounds including ergosta-4, 6, 8 (14), 22-tetraen-3-one, ergosterol 5, 8-endoperoxide, helvolic acid, aszonalenin (1), (3R)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodia...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070136
更新日期：2016-07-20 00:00:00
abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063091
更新日期：2014-05-27 00:00:00
abstract：:In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14050101
更新日期：2016-05-19 00:00:00
abstract：:This study aimed to investigate the cardiovascular effects elicited by Dictyota pulchella, a brown alga, using in vivo and in vitro approaches. In normotensive conscious rats, CH(2)Cl(2)/MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella produced dose-dependent hypotension (-4 ± 1; -8 ± 2; -53 ± 8 and ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9102075
更新日期：2011-01-01 00:00:00
abstract：:A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12084311
更新日期：2014-07-29 00:00:00
abstract：:Six new bis(indole) alkaloids (1-6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A-D (1-4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19010003
更新日期：2020-12-23 00:00:00
abstract：:This work aimed at improving the targeting and cytotoxicity of simvastatin (SMV) against colon cancer cells. SMV was encapsulated in chitosan polymers, followed by eudragit S100 microparticles. The release of SMV double coated microparticles was dependent on time and pH. At pH 7.4 maximum release was observed for 6 h....
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040226
更新日期：2020-04-24 00:00:00
abstract：:A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020084
更新日期：2019-02-01 00:00:00
abstract：:Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17030170
更新日期：2019-03-16 00:00:00
abstract：:Two new compounds-a trioxilin and a sulfoquinovosyl diacylglycerol (SQDG)-were isolated from the methanolic extract of the heterotrophic dinoflagellate Oxyrrhis marina cultivated by feeding on dried yeasts. The trioxilin was identified as (4Z,8E,13Z,16Z,19Z) -7(S),10(S),11(S)-trihydroxydocosapentaenoic acid (1), and t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030057
更新日期：2017-02-27 00:00:00
abstract：:In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11030611
更新日期：2013-02-26 00:00:00
abstract：:Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12010069
更新日期：2013-12-24 00:00:00
abstract：:Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md20080004
更新日期：2008-05-07 00:00:00
abstract：:Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050141
更新日期：2018-04-26 00:00:00
abstract：:In tumor development, the degradation of heparan sulfate (HS) by heparanase (HPSE) is associated with cell-surface and extracellular matrix remodeling as well as the release of HS-bound signaling molecules, allowing cancer cell migration, invasion and angiogenesis. Because of their structural similarity with HS, sulfa...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030140
更新日期：2019-02-27 00:00:00
abstract：:Ice-binding protein (IBPs) protect cells from cryo-injury during cryopreservation by inhibiting ice recrystallization (IR), which is a main cause of cell death. In the present study, we employed two IBPs, one, designated LeIBP from Arctic yeast, and the other, designated FfIBP from Antarctic sea ice bacterium, in the ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120372
更新日期：2017-12-01 00:00:00
abstract：:The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13052875
更新日期：2015-05-08 00:00:00
abstract：:Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragment...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13020770
更新日期：2015-02-02 00:00:00
abstract：:Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 w...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15020043
更新日期：2017-02-17 00:00:00
abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17040234
更新日期：2019-04-19 00:00:00
abstract：:Functional feed supplemented with alternative-economic nutrient sources (protein, carbohydrates, lipids) and probiotics are being considered in shrimp/fish aquaculture production systems as an option to increase yield and profits and to reduce water pollution. In this study the probiotic potential to formulate functio...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9061119
更新日期：2011-01-01 00:00:00
abstract：:Two new piperazine-triones lansai E and F (1, 2), together with four known secondary metabolites lansai D (3), 1-N-methyl-(E,Z)-albonoursin (4), imidazo[4,5-e]-1,2,4-triazine (5), and streptonigrin (6) were isolated from a deep-sea-derived Streptomycetes sp. strain SMS636. The structures of the isolated compounds were...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030186
更新日期：2019-03-21 00:00:00
