Abstract:
:Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, oncoVV-HddSBL, in which a gene encoding Haliotis discus discus sialic acid-binding lectin (HddSBL) was inserted into oncoVV, significantly prolonged the survival of mice as compared to the control virus. HddSBL reduced the tumor secreted serum rat IL-2 level upregulated by oncoVV, promoted viral replication, as well as inhibited the expression of antiviral factors in C6 glioblastoma cell line. Furthermore, HddSBL downregulated the expression levels of histone H3 and H4, and upregulated histone H3R8 and H4R3 asymmetric dimethylation, confirming the effect of HddSBL on chromatin structure suggested by the transcriptome data. Our results might provide insights into the utilization of HddSBL in counteracting the adverse effects of oncolytic vaccinia virus.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Li G,Mei S,Cheng J,Wu T,Luo Jdoi
10.3390/md16050141subject
Has Abstractpub_date
2018-04-26 00:00:00issue
5issn
1660-3397pii
md16050141journal_volume
16pub_type
杂志文章相关文献
Marine Drugs文献大全abstract::TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12095072
更新日期:2014-09-25 00:00:00
abstract::Sulphated polysaccharides with anti-thrombotic and anti-coagulant activities have been found in various marine biota. In this study, a previously characterised anti-thrombotic and anti-coagulant extract from blacklip abalone was fractionated by anion exchange chromatography (AEC), pooled (on a sulphated polysaccharide...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15080240
更新日期:2017-08-04 00:00:00
abstract::Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9112369
更新日期:2011-01-01 00:00:00
abstract::Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17050299
更新日期:2019-05-20 00:00:00
abstract::An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11010099
更新日期:2013-01-10 00:00:00
abstract::When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080419
更新日期:2020-08-10 00:00:00
abstract::Sponges are important sources of bioactive secondary metabolites. These compounds are frequently synthesized by bacterial symbionts, which may be recruited from the surrounding seawater or transferred to the sponge progeny by the parent. In this study, we investigated the bacterial communities associated with the spon...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15040095
更新日期:2017-03-25 00:00:00
abstract::Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11093517
更新日期:2013-09-17 00:00:00
abstract::In our search for bioactive metabolites from marine organisms, we have investigated the polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive chromatographic separations and final HPLC purification of the potent antifungal fraction afforded a new bicyclic glycopeptide, theonellamid...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12041911
更新日期:2014-04-01 00:00:00
abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120377
更新日期:2017-12-04 00:00:00
abstract::Sea cucumbers have been valued for many centuries as a tonic and functional food, dietary delicacies and important ingredients of traditional medicine in many Asian countries. An assortment of bioactive compounds has been described in sea cucumbers. The most important and abundant secondary metabolites from sea cucumb...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md14080147
更新日期:2016-08-04 00:00:00
abstract::During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18110525
更新日期:2020-10-23 00:00:00
abstract::24-methyl-cholesta-5,24(28)-diene-3β,19-diol-7β-monoacetate (MeCDDA) is a natural steroid compound isolated from a wild-type soft coral (Nephthea erecta). The present study aimed to investigate the anti-small cell lung cancer (SCLC) effects of MeCDDA in vitro and in vivo, as well as to elucidate its underlying mechani...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15070210
更新日期:2017-07-01 00:00:00
abstract::The goal of this work was to identify sequences encoding monooxygenase biocatalysts with novel features by in silico mining an assembled metagenomic dataset of polar and subpolar marine sediments. The targeted enzyme sequences were Baeyer-Villiger and bacterial cytochrome P450 monooxygenases (CYP153). These enzymes ha...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15040114
更新日期:2017-04-09 00:00:00
abstract::Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15110354
更新日期:2017-11-10 00:00:00
abstract::Marine sponges are currently one of the richest sources of pharmacologically active compounds found in the marine environment. These bioactive molecules are often secondary metabolites, whose main function is to enable and/or modulate cellular communication and defense. They are usually produced by functional enzyme c...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md8102619
更新日期:2010-10-11 00:00:00
abstract::The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18120622
更新日期:2020-12-07 00:00:00
abstract::Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16020063
更新日期:2018-02-15 00:00:00
abstract::One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12074110
更新日期:2014-07-08 00:00:00
abstract::Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md9112176
更新日期:2011-01-01 00:00:00
abstract::Seaweed is a rich source of bioactive sulfated polysaccharides. We obtained six sulfated polysaccharide-rich fractions (UF-0.3, UF-0.5, UF-0.6, UF-0.7, UF-1.0, and UF-2.0) from the green seaweed Udotea flabellum (UF) by proteolytic digestion followed by sequential acetone precipitation. Biochemical analysis of these f...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16040135
更新日期:2018-04-20 00:00:00
abstract::Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md20080015
更新日期:2008-06-10 00:00:00
abstract::The red seaweed Pyropia yezoensis is an ideal research model for dissecting the molecular mechanisms underlying its robust acclimation to abiotic stresses in intertidal zones. Glycine betaine (GB) was an important osmolyte in maintaining osmotic balance and stabilizing the quaternary structure of complex proteins unde...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17010070
更新日期:2019-01-21 00:00:00
abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md11093381
更新日期:2013-09-06 00:00:00
abstract::Natural anionic polysaccharides fucosylated chondroitin sulfates (FCS) from sea cucumbers attract great attention nowadays due to their ability to influence various biological processes, such as blood coagulation, thrombosis, angiogenesis, inflammation, bacterial and viral adhesion. To determine pharmacophore fragment...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13020770
更新日期:2015-02-02 00:00:00
abstract::Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18080384
更新日期:2020-07-24 00:00:00
abstract::Marine biomass diversity is a tremendous source of potential anticancer compounds. Several natural marine products have been described to restore tumor cell sensitivity to TNF-related apoptosis inducing ligand (TRAIL)-induced cell death. TRAIL is involved during tumor immune surveillance. Its selectivity for cancer ce...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13116884
更新日期:2015-11-13 00:00:00
abstract::Gliotoxin, a secondary metabolite produced by marine fungus Aspergillus sp., possesses various biological activities including anticancer activity. However, the mechanism underlying gliotoxin-induced cytotoxicity on human cervical cancer (Hela) and human chondrosarcoma (SW1353) cells remains unclear. In this study, we...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12010069
更新日期:2013-12-24 00:00:00
abstract::Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compoun...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14060111
更新日期:2016-06-03 00:00:00
abstract::Nosocomial infections and increasing multi-drug resistance caused by Acinetobacter baumannii have been recognized as emerging problems worldwide. Moreover, A. baumannii is able to colonize various abiotic materials and medical devices, making it difficult to eradicate and leading to ventilator-associated pneumonia, an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14080143
更新日期:2016-07-29 00:00:00