Chitin Oligosaccharide Modulates Gut Microbiota and Attenuates High-Fat-Diet-Induced Metabolic Syndrome in Mice.

abstract：:Oxidative stress contributes to chronic inflammatory processes implicated in aging, referred to as "inflamm-aging." In this study, the potential anti-inflammatory and anti-aging effects of a pigment-protein complex (PPC) from Chlorella pyrenoidosa were investigated using lipopolysaccharide (LPS)-stimulated RAW 264.7 m...

journal_title：Marine drugs

authors： Zhang R,Chen J,Mao X,Qi P,Zhang X

更新日期：2019-10-16 00:00:00

abstract：:Natural polysaccharides exhibit beneficial immune modulatory effects, including immune stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, and its effect on tumor-bearing mice. Intravenous CFP treatment of C57BL/6 ...

journal_title：Marine drugs

authors： Park HB,Hwang J,Zhang W,Go S,Kim J,Choi I,You S,Jin JO

更新日期：2020-12-08 00:00:00

abstract：:Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 w...

journal_title：Marine drugs

authors： Xu X,Zhang X,Nong X,Wang J,Qi S

更新日期：2017-02-17 00:00:00

abstract：:Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its...

journal_title：Marine drugs

authors： Hannan MA,Dash R,Sohag AAM,Moon IS

更新日期：2019-11-13 00:00:00

abstract：:Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...

journal_title：Marine drugs

authors： Wiese J,Ohlendorf B,Blümel M,Schmaljohann R,Imhoff JF

更新日期：2011-01-01 00:00:00

abstract：:In 2011, a Diarrhetic Shellfish Poisoning (DSP) outbreak occurred in British Columbia (BC), Canada that was associated with cooked mussel consumption. This is the first reported DSP outbreak in BC. Investigation of ill individuals, traceback of product and laboratory testing for toxins were used in this investigation....

journal_title：Marine drugs

authors： Taylor M,McIntyre L,Ritson M,Stone J,Bronson R,Bitzikos O,Rourke W,Galanis E,Outbreak Investigation Team.

更新日期：2013-05-21 00:00:00

abstract：:In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...

journal_title：Marine drugs

authors： Park MK,Jung U,Roh C

更新日期：2011-01-01 00:00:00

abstract：:Metalloproteases are emerging as useful agents in the treatment of many diseases including arthritis, cancer, cardiovascular diseases, and fibrosis. Studies that could shed light on the metalloprotease pharmaceutical applications require the pure enzyme. Here, we reported the structure-based design and synthesis of th...

journal_title：Marine drugs

authors： Li S,Wang L,Xu X,Lin S,Wang Y,Hao J,Sun M

更新日期：2016-12-27 00:00:00

abstract：:The predatory marine gastropod Dicathais orbita has been the subject of a significant amount of biological and chemical research over the past five decades. Natural products research on D. orbita includes the isolation and identification of brominated indoles and choline esters as precursors of Tyrian purple, as well ...

journal_title：Marine drugs

authors： Benkendorff K

更新日期：2013-04-23 00:00:00

abstract：:Marine derived cyclo(Gly-l-Ser-l-Pro-l-Glu) was selected as a lead to evaluate antitumor-antibiotic activity. Histidine was chosen to replace the serine residue to form cyclo(Gly-l-His-l-Pro-l-Glu). Cyclic tetrapeptides (CtetPs) were then synthesized using a solution phase method, and subjected to antitumor and antibi...

journal_title：Marine drugs

authors： Chakraborty S,Tai DF,Lin YC,Chiou TW

更新日期：2015-05-15 00:00:00

abstract：:It is proven that β-amyloid (Aβ) aggregates containing cross-β-sheet structures led to oxidative stress, neuroinflammation, and neuronal loss via multiple pathways. Therefore, reduction of Aβ neurotoxicity via inhibiting aggregation of Aβ or dissociating toxic Aβ aggregates into nontoxic forms might be effective thera...

journal_title：Marine drugs

authors： Zhu L,Li R,Jiao S,Wei J,Yan Y,Wang ZA,Li J,Du Y

更新日期：2020-09-25 00:00:00

abstract：:Eight new compounds, sinulolides A-H (1-8), along with two known compounds, α-methoxy-2,3-dimethyl-butenolide (9) and sinularone D (10), were isolated from the soft coral Sinularia sp. The structures of these compounds were elucidated on the basis of extensive spectroscopic analysis. The absolute configurations were d...

journal_title：Marine drugs

authors： Yang B,Wei X,Huang J,Lin X,Liu J,Liao S,Wang J,Zhou X,Wang L,Liu Y

更新日期：2014-10-23 00:00:00

abstract：:The marine habitat provides a large number of structurally-diverse bioactive compounds for drug development. Marine sponges have been studied over many years and are found to be a rich source of these bioactive chemicals. This study is focused on the evaluation of the activity of six diterpene derivatives isolated fro...

journal_title：Marine drugs

authors： Leirós M,Sánchez JA,Alonso E,Rateb ME,Houssen WE,Ebel R,Jaspars M,Alfonso A,Botana LM

更新日期：2014-01-27 00:00:00

abstract：:In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...

journal_title：Marine drugs

authors： da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MR

更新日期：2016-05-19 00:00:00

abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

journal_title：Marine drugs

authors： Zhang W,Sun T,Ma Z,Li Y

更新日期：2014-04-22 00:00:00

abstract：:Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...

journal_title：Marine drugs

authors： Huang CY,Tseng WR,Ahmed AF,Chiang PL,Tai CJ,Hwang TL,Dai CF,Sheu JH

更新日期：2018-03-13 00:00:00

abstract：:To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wi...

journal_title：Marine drugs

authors： Zhang F,Braun DR,Rajski SR,DeMaria D,Bugni TS

更新日期：2019-12-12 00:00:00

abstract：:The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...

journal_title：Marine drugs

authors： Xie B,Huang Y,Baumann K,Fry BG,Shi Q

更新日期：2017-03-30 00:00:00

abstract：:The cultivation of macroalgae to supply the biofuel, pharmaceutical or food industries generates a considerable amount of organic residue, which represents a potential substrate for biomethanation. Its use optimizes the total resource exploitation by the simultaneous disposal of waste biomaterials. In this study, we e...

journal_title：Marine drugs

authors： Barbot YN,Thomsen C,Thomsen L,Benz R

更新日期：2015-09-18 00:00:00

abstract：:Marine cyanobacteria, notably those from tropical regions, are a rich source of bioactive secondary metabolites. Tropical marine cyanobacteria often grow to high densities in the environment, allowing direct isolation of many secondary metabolites from field-collected material. However, in temperate environments cultu...

journal_title：Marine drugs

authors： Leão PN,Ramos V,Gonçalves PB,Viana F,Lage OM,Gerwick WH,Vasconcelos VM

更新日期：2013-04-22 00:00:00

abstract：:Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...

journal_title：Marine drugs

authors： Shah SAA,Akhter N,Auckloo BN,Khan I,Lu Y,Wang K,Wu B,Guo YW

更新日期：2017-11-10 00:00:00

abstract：:The role of the marine environment in the development of anticancer drugs has been widely reviewed, particularly in recent years. However, the innovation in terms of clinical benefits has not been duly emphasized, although there are important breakthroughs associated with the use of marine-derived anticancer agents th...

journal_title：Marine drugs

authors： Pereira RB,Evdokimov NM,Lefranc F,Valentão P,Kornienko A,Pereira DM,Andrade PB,Gomes NGM

更新日期：2019-06-02 00:00:00

abstract：:Sea anemones are a remarkable source of active principles due to a decentralized venom system. New blood vessel growth or angiogenesis is a very promising target against cancer, but the few available antiangiogenic compounds have limited efficacy. In this study, a protein fraction, purified from tentacles of Anemonia ...

journal_title：Marine drugs

authors： Loret EP,Luis J,Nuccio C,Villard C,Mansuelle P,Lebrun R,Villard PH

更新日期：2018-04-19 00:00:00

abstract：:Tisochrysis lutea is a marine haptophyte rich in omega-3 polyunsaturated fatty acids (e.g., docosahexaenoic acid (DHA)) and carotenoids (e.g., fucoxanthin). Because of the nutraceutical applications of these compounds, this microalga is being used in aquaculture to feed oyster and shrimp larvae. In our earlier report,...

journal_title：Marine drugs

authors： Gangadhar KN,Rodrigues MJ,Pereira H,Gaspar H,Malcata FX,Barreira L,Varela J

更新日期：2020-11-19 00:00:00

abstract：:The potential anti-tumor agent wentilactones were produced by a newly isolated marine fungus Aspergillus dimorphicus. This fungus was derived from deep-sea sediment and identified by polyphasic approach, combining phenotypic, molecular, and extrolite profiles. However, wentilactone production was detected only under s...

journal_title：Marine drugs

authors： Xu R,Xu GM,Li XM,Li CS,Wang BG

更新日期：2015-11-19 00:00:00

abstract：:Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...

journal_title：Marine drugs

authors： Kellogg J,Grace MH,Lila MA

更新日期：2014-10-22 00:00:00

abstract：:Ulvan lyases can degrade ulvan to oligosaccharides with potent biological activity. A new ulvan lyase gene, ALT3695, was identified in Alteromonas sp. A321. Soluble expression of ALT3695 was achieved in Escherichia coli BL21 (DE3). The 1314-bp gene encoded a protein with 437 amino acid residues. The amino acid sequenc...

journal_title：Marine drugs

authors： Gao J,Du C,Chi Y,Zuo S,Ye H,Wang P

更新日期：2019-10-08 00:00:00

abstract：:Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...

journal_title：Marine drugs

authors： Wen J,Adams DJ,Hung A

更新日期：2020-07-03 00:00:00

abstract：:The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...

journal_title：Marine drugs

authors： Reen FJ,Gutiérrez-Barranquero JA,Dobson AD,Adams C,O'Gara F

更新日期：2015-05-13 00:00:00

abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...

journal_title：Marine drugs

authors： Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu K

更新日期：2017-05-18 00:00:00