Abstract:
:To date, a number of mannose-specific lectins have been isolated and characterized from seaweeds, especially from red algae. In fact, man-specific seaweed lectins consist of different structural scaffolds harboring a single or a few carbohydrate-binding sites which specifically recognize mannose-containing glycans. Depending on the structural scaffold, man-specific seaweed lectins belong to five distinct structurally-related lectin families, namely (1) the griffithsin lectin family (β-prism I scaffold); (2) the Oscillatoria agardhii agglutinin homolog (OAAH) lectin family (β-barrel scaffold); (3) the legume lectin-like lectin family (β-sandwich scaffold); (4) the Galanthus nivalis agglutinin (GNA)-like lectin family (β-prism II scaffold); and, (5) the MFP2-like lectin family (MFP2-like scaffold). Another algal lectin from Ulva pertusa, has been inferred to the methanol dehydrogenase related lectin family, because it displays a rather different GlcNAc-specificity. In spite of these structural discrepancies, all members from the five lectin families share a common ability to specifically recognize man-containing glycans and, especially, high-mannose type glycans. Because of their mannose-binding specificity, these lectins have been used as valuable tools for deciphering and characterizing the complex mannose-containing glycans from the glycocalyx covering both normal and transformed cells, and as diagnostic tools and therapeutic drugs that specifically recognize the altered high-mannose N-glycans occurring at the surface of various cancer cells. In addition to these anti-cancer properties, man-specific seaweed lectins have been widely used as potent human immunodeficiency virus (HIV-1)-inactivating proteins, due to their capacity to specifically interact with the envelope glycoprotein gp120 and prevent the virion infectivity of HIV-1 towards the host CD4+ T-lymphocyte cells in vitro.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Barre A,Simplicien M,Benoist H,Van Damme EJM,Rougé Pdoi
10.3390/md17080440subject
Has Abstractpub_date
2019-07-26 00:00:00issue
8issn
1660-3397pii
md17080440journal_volume
17pub_type
杂志文章,评审相关文献
Marine Drugs文献大全abstract::AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 reverse transcriptase (RT) inhibitory activity, such as the diterpenes...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11114127
更新日期:2013-10-29 00:00:00
abstract::The aim of the present work was to load a Hibiscus sabdariffa (HS) hydroalcoholic extract into in situ gelling formulations for the treatment of oral mucositis and esophagitis. Such formulations, selected as the most promising options in a previous work of ours, were composed by κ-carrageenan (κ-CG), a sulfated marine...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030153
更新日期:2019-03-05 00:00:00
abstract::Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17080472
更新日期:2019-08-15 00:00:00
abstract::In our current investigation, we evaluated the effect of Chlorella pyrenoidosa protein hydrolysate (CPPH) and Chlorella pyrenoidosa protein hydrolysate-calcium chelate (CPPH-Ca) on calcium absorption and gut microbiota composition, as well as their in vivo regulatory mechanism in SD rats fed low-calcium diets. Potent ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17060348
更新日期:2019-06-11 00:00:00
abstract::Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific abe...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md9091580
更新日期:2011-01-01 00:00:00
abstract::Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md9040561
更新日期:2011-01-01 00:00:00
abstract::Five new sulfide diketopiperazine derivatives, namely, penicibrocazines A-E (1-5), along with a known congener (6), were isolated and identified from the culture extract of Penicillium brocae MA-231, an endophytic fungus obtained from the fresh tissue of the marine mangrove plant Avicennia marina. The structures of th...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13010276
更新日期:2015-01-07 00:00:00
abstract::In this study, we developed novel chitosan/fucoidan nanoparticles (CS/F NPs) using a simple polyelectrolyte self-assembly method and evaluated their potential to be antioxidant carriers. As the CS/F weight ratio was 5/1, the CS/F NPs were spherical and exhibited diameters of approximately 230-250 nm, as demonstrated b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12084379
更新日期:2014-07-31 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a malignant tumor that can cause systemic invasion; however, the exact etiology and molecular mechanism are unknown. Astaxanthin (ASX), a powerful antioxidant, has efficient anti-oxidant, anti-inflammatory, and other activities, and has great research prospects in cancer therapy. We s...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md13106064
更新日期:2015-09-24 00:00:00
abstract::Being able to quantify ichthyotoxic metabolites from microalgae allows for the determination of ecologically-relevant concentrations that can be simulated in laboratory experiments, as well as to investigate bioaccumulation and degradation. Here, the ichthyotoxin karmitoxin, produced by Karlodinium armiger, was quanti...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15090278
更新日期:2017-08-31 00:00:00
abstract::Oxylipins such as polyunsaturated aldehydes (PUAs) and hydroxyacids (HEPEs) are signaling molecules derived from the oxidation of polyunsaturated fatty acids. They are common in diatoms that constitute a major group of microalgae in freshwater and oceanic ecosystems. Although HEPEs represent the most common oxylipins ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030144
更新日期:2019-03-01 00:00:00
abstract::Magnetotactic bacteria (MTB) produce intracellular organelles called magnetosomes which are magnetic nanoparticles composed of magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a lipid bilayer. The synthesis of a magnetosome is through a genetically controlled process in which the bacterium has control over the compo...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md13010389
更新日期:2015-01-16 00:00:00
abstract::In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md12115503
更新日期:2014-11-19 00:00:00
abstract::Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities. We report here for the first time, the presence of high molecular weight compounds that participate in the envenomation cocktail used by these marine snails. ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md10020258
更新日期:2012-02-01 00:00:00
abstract::A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16100349
更新日期:2018-09-24 00:00:00
abstract::Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17090539
更新日期:2019-09-17 00:00:00
abstract::Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md19020067
更新日期:2021-01-27 00:00:00
abstract::Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md15120369
更新日期:2017-12-01 00:00:00
abstract::Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18080379
更新日期:2020-07-22 00:00:00
abstract::Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md15110354
更新日期:2017-11-10 00:00:00
abstract::High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) ...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md18030148
更新日期:2020-03-04 00:00:00
abstract::Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md18080384
更新日期:2020-07-24 00:00:00
abstract::To sustainably produce marine fish with a high lipid quality rich in omega-3 fatty acids, alternative sources of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are being identified. Moreover, the use of bioactive compounds that would stimulate the in vivo fatty acid synthesis, such as resveratrol (RV), wou...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16100379
更新日期:2018-10-10 00:00:00
abstract::Fucosterol from edible brown seaweeds has various biological activities, including anti-inflammatory, anti-adipogenic, antiphotoaging, anti-acetylcholinesterase, and anti-beta-secretase 1 activities. However, little is known about its effects on soluble amyloid beta peptide (sAβ)-induced endoplasmic reticulum (ER) str...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md16100368
更新日期:2018-10-05 00:00:00
abstract::Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute con...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17110596
更新日期:2019-10-23 00:00:00
abstract::Nosocomial infections and increasing multi-drug resistance caused by Acinetobacter baumannii have been recognized as emerging problems worldwide. Moreover, A. baumannii is able to colonize various abiotic materials and medical devices, making it difficult to eradicate and leading to ventilator-associated pneumonia, an...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md14080143
更新日期:2016-07-29 00:00:00
abstract::In continuation of our search for drug leads from Red Sea sponges we have investigated the ethyl acetate fraction of the organic extract of the Red Sea sponge Hyrtios species. Bioassay-directed fractionation of the active fraction resulted into the identification of three new alkaloids, hyrtioerectines D-F (1-3). Hyrt...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md11041061
更新日期:2013-03-28 00:00:00
abstract::Domoic acid produced by marine algae has been shown to cause acute and chronic neurologic sequelae in Californian sea lions following acute or low-dose exposure. Histological findings in affected animals included a degenerative cardiomyopathy that was hypothesized to be caused by over-excitation of the glutamate recep...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md8051637
更新日期:2010-05-06 00:00:00
abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...
journal_title:Marine drugs
pub_type: 杂志文章,评审
doi:10.3390/md12031185
更新日期:2014-03-06 00:00:00
abstract::Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...
journal_title:Marine drugs
pub_type: 杂志文章
doi:10.3390/md17030185
更新日期:2019-03-20 00:00:00