Abstract：
:Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute configurations were unambiguously determined through quantum chemical calculations, as well as DP4+ probability simulations. The proposed biosynthetic pathway suggested 1-3 were generated from unusual L-Phe and D-Ser. All the isolates were evaluated for their cytotoxicity against four tumor cell lines.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Liu Z,Fan Z,Sun Z,Liu H,Zhang Wdoi
10.3390/md17110596subject
Has Abstractpub_date
2019-10-23 00:00:00issue
11issn
1660-3397pii
md17110596journal_volume
17pub_type
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