Penicibrocazines A-E, five new sulfide diketopiperazines from the marine-derived endophytic fungus Penicillium brocae.

abstract：:A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol...

journal_title：Marine drugs

authors： Wang W,Wan X,Liu J,Wang J,Zhu H,Chen C,Zhang Y

更新日期：2018-05-02 00:00:00

abstract：:Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...

journal_title：Marine drugs

authors： Fuochi V,Li Volti G,Camiolo G,Tiralongo F,Giallongo C,Distefano A,Petronio Petronio G,Barbagallo I,Viola M,Furneri PM,Di Rosa M,Avola R,Tibullo D

更新日期：2017-11-01 00:00:00

abstract：:Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

journal_title：Marine drugs

authors： Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

更新日期：2018-02-28 00:00:00

abstract：:Food protein hydrolysates are known to exhibit angiotensin converting enzyme (ACE) inhibitory properties and can be used as a novel functional food for prevention of hypertension. This study evaluated the ACE inhibitory potentials of Actinopyga lecanora proteolysate (ALP) in vivo. The pre-fed rats with ALP at various ...

journal_title：Marine drugs

authors： Sadegh Vishkaei M,Ebrahimpour A,Abdul-Hamid A,Ismail A,Saari N

更新日期：2016-09-30 00:00:00

abstract：:Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae as a great source o...

journal_title：Marine drugs

authors： Genovese G,Tedone L,Hamann MT,Morabito M

更新日期：2009-08-11 00:00:00

abstract：:Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

journal_title：Marine drugs

authors： Kumar SR,Hosokawa M,Miyashita K

更新日期：2013-12-16 00:00:00

abstract：:Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...

journal_title：Marine drugs

authors： Drotningsvik A,Vikøren LA,Mjøs SA,Oterhals Å,Pampanin D,Flesland O,Gudbrandsen OA

更新日期：2018-05-01 00:00:00

abstract：:MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc). MytiLec revealed β-trefoil folding as also found in the ricin B-subunit type (R-type) lectin family, although the amino acid sequences were quite different....

journal_title：Marine drugs

authors： Hasan I,Sugawara S,Fujii Y,Koide Y,Terada D,Iimura N,Fujiwara T,Takahashi KG,Kojima N,Rajia S,Kawsar SM,Kanaly RA,Uchiyama H,Hosono M,Ogawa Y,Fujita H,Hamako J,Matsui T,Ozeki Y

更新日期：2015-12-14 00:00:00

abstract：:The benefit of carotenoids to human health is undeniable and consequently, their use for this purpose is growing rapidly. Additionally, the nutraceutical properties of carotenoids have attracted attention of the food industry, especially in a new market area, the 'cosmeceuticals.' Marine organisms (microalgae, seaweed...

journal_title：Marine drugs

authors： Viera I,Pérez-Gálvez A,Roca M

更新日期：2018-10-22 00:00:00

abstract：:Hepatic fibrosis is an effusive wound healing process, characterized by an excessive deposition of extracellular matrix (ECM), as the consequence of chronic liver injury of any etiology. Current therapeutic repertoire for hepatic fibrosis is limited to withdrawal of the noxious agent, which is not always feasible. Hen...

journal_title：Marine drugs

authors： Wang Y,Zhang X,Yang Y,Yang X,Ye B

更新日期：2015-08-18 00:00:00

abstract：:Pectenotoxin-2 (PTX-2), which was first identified as a cytotoxic entity in marine sponges, has been reported to display significant cytotoxicity to human cancer cells where it inhibits mitotic separation and cytokinesis through the depolymerization of actin filaments. In the late stage of endoreduplication, the effec...

journal_title：Marine drugs

authors： Kim GY,Kim WJ,Choi YH

更新日期：2011-01-01 00:00:00

abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...

journal_title：Marine drugs

authors： Ding CYG,Pang LM,Liang ZX,Goh KKK,Glukhov E,Gerwick WH,Tan LT

更新日期：2018-12-13 00:00:00

abstract：:Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...

journal_title：Marine drugs

authors： He Q,Sun R,Liu H,Geng Z,Chen D,Li Y,Han J,Lin W,Du S,Deng Z

更新日期：2014-03-28 00:00:00

abstract：:Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...

journal_title：Marine drugs

authors： Laje K,Seger M,Dungan B,Cooke P,Polle J,Holguin FO

更新日期：2019-03-22 00:00:00

abstract：:Mouse bioassay is the official testing method to quantify paralytic shellfish toxins (PSTs) in bivalves. A number of alternative analytical methods have been reported. Some methods have been evaluated by a single laboratory validation. Among the different types of methods, chemical analyses are capable of identifying ...

journal_title：Marine drugs

authors： Watanabe R,Suzuki T,Oshima Y

更新日期：2011-03-22 00:00:00

abstract：:Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of th...

journal_title：Marine drugs

authors： Sproule A,Correa H,Decken A,Haltli B,Berrué F,Overy DP,Kerr RG

更新日期：2019-06-11 00:00:00

abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...

journal_title：Marine drugs

authors： Ryu YS,Fernando PDSM,Kang KA,Piao MJ,Zhen AX,Kang HK,Koh YS,Hyun JW

更新日期：2019-04-19 00:00:00

abstract：:Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...

journal_title：Marine drugs

authors： Wang X,Schröder HC,Feng Q,Draenert F,Müller WE

更新日期：2013-03-08 00:00:00

abstract：:Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar...

journal_title：Marine drugs

authors： Bae M,Kim H,Shin Y,Kim BY,Lee SK,Oh KB,Shin J,Oh DC

更新日期：2013-08-13 00:00:00

abstract：:Cyclic imines are lipophilic marine toxins that bioaccumulate in seafood. Their structure comprises a cyclic-imino moiety, responsible for acute neurotoxicity in mice. Cyclic imines have not been linked yet to human poisonings and are not regulated in Europe, although the European Food Safety Authority requires more d...

journal_title：Marine drugs

authors： García-Altares M,Casanova A,Bane V,Diogène J,Furey A,de la Iglesia P

更新日期：2014-06-23 00:00:00

abstract：:The effect of carrageenans on tomato chlorotic dwarf viroid (TCDVd) replication and symptom expression was studied. Three-week-old tomato plants were spray-treated with iota(ɩ)-, lambda(λ)-, and kappa(κ)-carrageenan at 1 g·L-1 and inoculated with TCDVd after 48 h. The λ-carrageenan significantly suppressed viroid symp...

journal_title：Marine drugs

authors： Sangha JS,Kandasamy S,Khan W,Bahia NS,Singh RP,Critchley AT,Prithiviraj B

更新日期：2015-05-08 00:00:00

abstract：:Nanoparticle drug delivery (NDDS) is a novel system in which the drugs are delivered to the site of action by small particles in the nanometer range. Natural or synthetic polymers are used as vectors in NDDS, as they provide targeted, sustained release and biodegradability. Here, we used the chitosan and hepatoma cell...

journal_title：Marine drugs

authors： Cheng M,Gao X,Wang Y,Chen H,He B,Xu H,Li Y,Han J,Zhang Z

更新日期：2013-09-17 00:00:00

abstract：:Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...

journal_title：Marine drugs

authors： Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

更新日期：2020-11-29 00:00:00

abstract：:In our search for quorum-sensing (QS) disrupting molecules, 75 fungal isolates were recovered from reef organisms (endophytes), saline lakes and mangrove rhizosphere. Their QS inhibitory activity was evaluated in Chromobacterium violaceum CVO26. Four strains of endophytic fungi stood out for their potent activity at c...

journal_title：Marine drugs

authors： Martín-Rodríguez AJ,Reyes F,Martín J,Pérez-Yépez J,León-Barrios M,Couttolenc A,Espinoza C,Trigos A,Martín VS,Norte M,Fernández JJ

更新日期：2014-11-19 00:00:00

abstract：:A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...

journal_title：Marine drugs

authors： Cheng Z,Liu W,Fan R,Han S,Li Y,Cui X,Zhang J,Wu Y,Lv X,Zhang Y,Luo Z,Alias SA,Xu W,Li Q

更新日期：2020-03-16 00:00:00

abstract：:Collagen has become a key-molecule in cell culture studies and in the tissue engineering field. Industrially, the principal sources of collagen are calf skin and bones which, however, could be associated to risks of serious disease transmission. In fact, collagen derived from alternative and riskless sources is requir...

journal_title：Marine drugs

authors： Benedetto CD,Barbaglio A,Martinello T,Alongi V,Fassini D,Cullorà E,Patruno M,Bonasoro F,Barbosa MA,Carnevali MD,Sugni M

更新日期：2014-09-24 00:00:00

abstract：:The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

journal_title：Marine drugs

authors： Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

更新日期：2018-11-16 00:00:00

abstract：:Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...

journal_title：Marine drugs

authors： Turk T,Frangez R,Sepcić K

更新日期：2007-11-13 00:00:00

abstract：:Collagen is the major fibrillar protein in most living organisms. Among the different types of collagen, type I collagen is the most abundant one in tissues of marine invertebrates. Due to the health-related risk factors and religious constraints, use of mammalian derived collagen has been limited. This triggers the s...

journal_title：Marine drugs

authors： Senadheera TRL,Dave D,Shahidi F

更新日期：2020-09-18 00:00:00

abstract：:Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...

journal_title：Marine drugs

authors： Deeds JR,Landsberg JH,Etheridge SM,Pitcher GC,Longan SW

更新日期：2008-06-10 00:00:00