Abstract：
:Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (deSSP) as the C/N source. The half maximal inhibitory concentration (IC50) and maximum aGI activity of fermented deCSP (38 µg/mL, 98%), deSSP (108 µg/mL, 89%), squid pen powder (SPP) (422 µg/mL, 98%), and shrimp head powder (SHP) (455 µg/mL, 92%) were compared with those of fermented nutrient broth (FNB) (81 µg/mL, 93%) and acarbose (1095 µg/mL, 74%), a commercial antidiabetic drug. The result of the protein/chitin ratio on aGI production showed that the optimal ratio was 0.2/1. Fermented deCSP showed lower IC50 and higher maximum inhibitory activity than those of acarbose against rat intestinal α-glucosidase.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Nguyen VB,Wang SLdoi
10.3390/md15110350subject
Has Abstractpub_date
2017-11-07 00:00:00issue
11issn
1660-3397pii
md15110350journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Four 4-hydroxy-α-pyrones including three new ones named nipyrones A-C (1-3) together with one known analogue germicidin C (4) were discovered from a marine sponge-derived fungus Aspergillus niger cultivated in a solid rice culture. Their structures and absolute configurations were elucidated through a combination of s...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060344
更新日期：2019-06-10 00:00:00
abstract：:Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md7040787
更新日期：2009-12-02 00:00:00
abstract：:In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md8030658
更新日期：2010-03-16 00:00:00
abstract：:Several known sesquiterpenoid quinones and quinols (1-9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongiaelegans. The planar structure of 10 was determined from spectroscopic analyses, and its relative and a...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17070423
更新日期：2019-07-19 00:00:00
abstract：:Biologically active compounds with different modes of action, such as, antiproliferative, antioxidant, antimicrotubule, have been isolated from marine sources, specifically algae and cyanobacteria. Recently research has been focused on peptides from marine animal sources, since they have been found as secondary metabo...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md10050963
更新日期：2012-05-01 00:00:00
abstract：:Diabetes mellitus is a group of metabolic disorders of the endocrine system characterised by hyperglycaemia. Type II diabetes mellitus (T2DM) constitutes the majority of diabetes cases around the world and are due to unhealthy diet, sedentary lifestyle, as well as rise of obesity in the population, which warrants the ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13085447
更新日期：2015-08-21 00:00:00
abstract：:Seven new polyoxygenated steroids belonging to a new structural group of sponge steroids, gracilosulfates A-G (1-7), possessing 3β-O-sulfonato, 5β,6β epoxy (or 5(6)-dehydro), and 4β,23-dihydroxy substitution patterns as a common structural motif, were isolated from the marine sponge Haliclona gracilis. Their structure...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18090454
更新日期：2020-08-30 00:00:00
abstract：:Drug-resistant Staphylococcus aureus is a continuing public health concern, both in the hospital and community settings. Antibacterial compounds that possess novel structural scaffolds and are effective against multiple S. aureus strains, including current drug-resistant ones, are needed. Previously, we have described...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10051103
更新日期：2012-05-01 00:00:00
abstract：:Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18110561
更新日期：2020-11-17 00:00:00
abstract：:A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivative...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16030090
更新日期：2018-03-12 00:00:00
abstract：:Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18080379
更新日期：2020-07-22 00:00:00
abstract：:During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18110525
更新日期：2020-10-23 00:00:00
abstract：:Actinoporins are α-pore forming proteins with therapeutic potential, produced by sea anemones. Sticholysin II (StnII) from Stichodactyla helianthus is one of its most extensively characterized members. These proteins remain stably folded in water, but upon interaction with lipid bilayers, they oligomerize to form a po...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13041647
更新日期：2015-03-25 00:00:00
abstract：:Four new cembrane-type diterpenoids, sarcophyolides B-E (1-4), along with 11 known analogues were isolated from the soft coral Sarcophyton elegans. The structures of new compounds 1-4 were established on the basis of spectroscopic analysis and chemical conversion. The new cembranoids sarcophyolides B (1) and lobocraso...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11093186
更新日期：2013-08-26 00:00:00
abstract：:Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17080472
更新日期：2019-08-15 00:00:00
abstract：:Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17050307
更新日期：2019-05-24 00:00:00
abstract：:Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10112596
更新日期：2012-11-21 00:00:00
abstract：:Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15070219
更新日期：2017-07-11 00:00:00
abstract：:In the present study, histone from immature testis of Atlantic salmon was extracted and identified, and its antibacterial activity after enzymolysis was investigated. Histone extracted from Atlantic salmon (Salmo salar) testis using the acid extraction method was successfully identified by LC-MS/MS, and revealed signi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030133
更新日期：2020-02-26 00:00:00
abstract：:A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora of many TTX-bearing hosts, thereby providing strong support for ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18030177
更新日期：2020-03-23 00:00:00
abstract：:Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16070218
更新日期：2018-06-25 00:00:00
abstract：:In this study, we aimed to illustrate the potential bio-effects of 3-bromo-4,5-dihydroxybenzaldehyde (3-BDB) on the antioxidant/cytoprotective enzyme heme oxygenase-1 (HO-1) in keratinocytes. The antioxidant effects of 3-BDB were examined via reverse transcription PCR, Western blotting, HO-1 activity assay, and immuno...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17040234
更新日期：2019-04-19 00:00:00
abstract：:Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050149
更新日期：2018-05-01 00:00:00
abstract：:Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16020063
更新日期：2018-02-15 00:00:00
abstract：:Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18120604
更新日期：2020-11-29 00:00:00
abstract：:Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020101
更新日期：2020-02-04 00:00:00
abstract：:Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 μg/mL. In addition...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9071187
更新日期：2011-01-01 00:00:00
abstract：:Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17030138
更新日期：2019-02-27 00:00:00
abstract：:Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable anti...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040117
更新日期：2018-04-05 00:00:00
abstract：:Six new polyoxygenated cembrane-based diterpenoids, stellatumolides A⁻C (1⁻3), stellatumonins A and B (4 and 5), and stellatumonone (6), were isolated together with ten known related compounds (7⁻16) from the ethyl acetate (EtOAc) extract of soft coral Sarcophyton stellatum. The structures of the new compounds were es...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16060210
更新日期：2018-06-14 00:00:00
