Abstract:
:A member of the marine streptomycete clade MAR4, Streptomyces sp. CNQ-509, has genetic potential for the biosynthesis of hybrid isoprenoids and produces several meroterpenoids such as naphterpin, nitropyrrolin and marinophenazine. Our research on the strain CNQ-509 led to the isolation of two new naphterpin derivatives (1 and 2) comprised of naphthoquinone and geranyl moieties along with the known terpenoid, debromomarinone. The two-dimensional structure of these compounds was determined through spectral data analysis using data from NMR, MS and UV spectroscopy. Furthermore, the full structures of 1 and 2 including absolute configurations were unequivocally established by a combination of NMR experiments and chemical modifications.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Park JS,Kwon HCdoi
10.3390/md16030090subject
Has Abstractpub_date
2018-03-12 00:00:00issue
3issn
1660-3397pii
md16030090journal_volume
16pub_type
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