Abstract：
:Ieodomycin B, which shows in vitro antimicrobial activity, was isolated from a marine Bacillus species. A novel asymmetric total synthetic approach to ieodomycin B using commercially available geraniol was achieved. The approach involves the generation of 1,3-trans-dihydroxyl at C-3 and C-5 positions via a Crimmins-modified Evans aldol reaction and a chelation-controlled Mukaiyama aldol reaction of a p-methoxybenzyl-protected aldehyde, as well as the generation of a lactone ring in a deprotection-lactonization one-pot reaction.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Lin S,Zhang J,Zhang Z,Xu T,Huang S,Wang Xdoi
10.3390/md15010017subject
Has Abstractpub_date
2017-01-18 00:00:00issue
1issn
1660-3397pii
md15010017journal_volume
15pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Cold-adapted enzymes produced by psychrophilic organisms have elevated catalytic activities at low temperatures compared to their mesophilic counterparts. This is largely due to amino acids changes in the protein sequence that often confer increased molecular flexibility in the cold. Comparison of structural changes b...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md19020067
更新日期：2021-01-27 00:00:00
abstract：:TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12095072
更新日期：2014-09-25 00:00:00
abstract：:Fish oil is used in the production of feed for cultured fish owing to its high polyunsaturated fatty acid content (PUFA). The over-exploitation of fisheries and events like "El Niño" are reducing the fish oil supply. Some marine microorganisms are considered potentially as alternative fatty acid sources. This study as...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120369
更新日期：2017-12-01 00:00:00
abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100349
更新日期：2018-09-24 00:00:00
abstract：:Three new diphenyl ether derivatives-phomaethers A-C (1-3) and five known compounds-including a diphenyl ether analog, 2,3'-dihydroxy-4-methoxy-5',6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)-were isolated...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15060146
更新日期：2017-05-25 00:00:00
abstract：:Pinnatoxins (PnTXs) are emerging neurotoxins that were discovered about 30 years ago. They are solely produced by the marine dinoflagellate Vulcanodinium rugosum, and may be transferred into the food chain, as they have been found in various marine invertebrates, including bivalves. No human intoxication has been repo...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md17070425
更新日期：2019-07-20 00:00:00
abstract：:Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13116687
更新日期：2015-10-30 00:00:00
abstract：:The tropical marine cyanobacterium Moorena bouillonii occupies a large geographic range across the Indian and Western Tropical Pacific Oceans and is a prolific producer of structurally unique and biologically active natural products. An ensemble of computational approaches, including the creation of the ORCA (Objectiv...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100515
更新日期：2020-10-14 00:00:00
abstract：:Lung cancer is a leading cause of tumor-associated mortality. Fascaplysin, a bis-indole of a marine sponge, exhibit broad anticancer activity as specific CDK4 inhibitor among several other mechanisms, and is investigated as a drug to overcome chemoresistance after the failure of targeted agents or immunotherapy. The c...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100383
更新日期：2018-10-14 00:00:00
abstract：:Fungi associated with the marine sponge Tethya aurantium were isolated and identified by morphological criteria and phylogenetic analyses based on internal transcribed spacer (ITS) regions. They were evaluated with regard to their secondary metabolite profiles. Among the 81 isolates which were characterized, members o...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9040561
更新日期：2011-01-01 00:00:00
abstract：:For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat mo...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14070121
更新日期：2016-06-24 00:00:00
abstract：:Carrageenans are abundant and safe non-starch polysaccharides exerting their biological effects in living organisms. Apart from their known pro-inflammation properties and some pharmacological activity, carrageenans can also strongly bind and hold metal ions. This property can be used for creation of the new drugs for...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md8041106
更新日期：2010-04-01 00:00:00
abstract：:Protamine sulfate (PS) is a polycationic protein drug obtained from the sperm of fish, and is used to reverse the anticoagulant effect of unfractionated heparin (UFH). However, the interactions between PS, UFH, and platelets are still not clear. We measured the platelet numbers and collagen-induced aggregation, P-sele...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17090539
更新日期：2019-09-17 00:00:00
abstract：:Numerous antimicrobial peptides (AMPs) from marine fish have been identified, isolated and characterized. These peptides act as host defense molecules that exert antimicrobial effects by targeting the lipopolysaccharide (LPS) of Gram-negative bacteria. The LPS-AMP interactions are driven by the biophysical properties ...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12031471
更新日期：2014-03-13 00:00:00
abstract：:Carotenoids are natural pigments that contribute to light harvesting and photo-protection in photosynthetic organisms. In this study, we analyzed the carotenoid profiles, including mono-hydroxy and epoxy-carotenoids, in the economically valuable red seaweed Pyropia yezoensis, to clarify the detailed biosynthetic and m...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16110426
更新日期：2018-11-01 00:00:00
abstract：:Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15100301
更新日期：2017-09-30 00:00:00
abstract：BACKGROUND:Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phas...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030074
更新日期：2017-03-15 00:00:00
abstract：:Three new butenolide derivatives, namely aspernolides N-P (1-3), together with six known analogues (4-9), were isolated from the ethyl acetate (EtOAc) extract of the deep sea-derived fungus Aspergillus terreus YPGA10. The structures of compounds 1-3 were determined on the basis of comprehensive analyses of the nuclear...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17060332
更新日期：2019-06-03 00:00:00
abstract：:α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16060215
更新日期：2018-06-20 00:00:00
abstract：:An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11010099
更新日期：2013-01-10 00:00:00
abstract：:The biosynthetic gene cluster for bisucaberin B (1, bsb gene cluster), an N-hydroxy-N-succinyl diamine (HSD)-based siderophore, was cloned from the marine bacterium Tenacibaculum mesophilum, originated from a marine sponge. The bsb gene cluster consists of six open reading frames (ORFs), in contrast to the four ORFs t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16090342
更新日期：2018-09-19 00:00:00
abstract：:During an investigation of the chemistry of the Red Sea Verongiid sponge Pseudoceratina arabica, we discovered a small molecule, pseudoceratonic acid (1), along with the new moloka'iamine derivatives, ceratinines N (2), O (3), and the previously reported compounds moloka'iamine (4), hydroxymoloka'iamine (5) and cerati...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18110525
更新日期：2020-10-23 00:00:00
abstract：:Despite intense efforts to develop non-cytotoxic anticancer treatments, effective agents are still not available. Therefore, novel apoptosis-inducing drug leads that may be developed into effective targeted cancer therapies are of interest to the cancer research community. Targeted cancer therapies affect specific abe...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9091580
更新日期：2011-01-01 00:00:00
abstract：:Astaxanthin (AXT), a xanthophyll carotenoid compound, has potent antioxidant, anti-inflammatory and neuroprotective properties. Neuroinflammation and oxidative stress are significant in the pathogenesis and development of Alzheimer's disease (AD). Here, we studied whether AXT could alleviate neuroinflammation, oxidati...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17020123
更新日期：2019-02-18 00:00:00
abstract：:Global incidence of type 2 diabetes has escalated over the past few decades, necessitating a continued search for natural sources of enzyme inhibitors to offset postprandial hyperglycemia. The objective of this study was to evaluate coastal Alaskan seaweed inhibition of α-glucosidase and α-amylase, two carbolytic enzy...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12105277
更新日期：2014-10-22 00:00:00
abstract：:Impaired wound healing is a major clinical problem in patients with diabetes and is the leading cause of lower limb amputation. This study is aimed to observe the effects of small molecule oligopeptides isolated from sea cucumber (SCCOPs) on the wound healing process in diabetic mice. Ninety db/db male mice were divid...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16010016
更新日期：2018-01-08 00:00:00
abstract：:Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md7040787
更新日期：2009-12-02 00:00:00
abstract：:Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md11030718
更新日期：2013-03-08 00:00:00
abstract：:Bacteria belonging to the Vibrionaceae family are widespread in the marine environment. Today, 128 species of vibrios are known. Several of them are infamous for their pathogenicity or symbiotic relationships. Despite their ability to interact with eukaryotes, the vibrios are greatly underexplored for their ability to...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md9091440
更新日期：2011-01-01 00:00:00
abstract：:The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040218
更新日期：2020-04-17 00:00:00
