Abstract：
:Infection with Helicobacter pylori is a critical cause of gastrointestinal diseases. A crucial host response associated with H. pylori infection includes gastric inflammation, which is characterized by a sustained recruitment of T-helper (Th) cells to the site of infection and distinct patterns of cytokine production. Adequate nutritional status, especially frequent consumption of dietary antioxidants, appears to protect against infection with H. pylori. The aim of the present study was to investigate whether astaxanthin (AXT) from shrimp cephalothorax may modulate cytokine release of splenocytes in H. pylori-infected mice (n = 60). Six- to eight-week-old female mice were divided into three groups (n = 20 per group) to receive a daily oral dose of 10 or 40 mg of AXT for six weeks. After six weeks, a trend toward interferon gamma (IFN-γ) upregulation was found (40 mg; p < 0.05) and a significant dose-dependent increase of interleukin 2 (IL-2) and IL-10 (both p < 0.05) was observed. These results suggest that AXT induces higher levels of IL-2 and a shift to a balanced Th1/Th2 response by increasing IFN-γ and augmenting IL-10. We concluded that AXT may influence the pattern of cytokines during H. pylori infection.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Davinelli S,Melvang HM,Andersen LP,Scapagnini G,Nielsen MEdoi
10.3390/md17070382subject
Has Abstractpub_date
2019-06-26 00:00:00issue
7issn
1660-3397pii
md17070382journal_volume
17pub_type
杂志文章相关文献
Marine Drugs文献大全abstract：:Mexico is one of the three areas of the world with the greatest terrestrial and cultural biological diversity. The diversity of Mexican medicinal flora has been studied for a long time and several bioactive compounds have been isolated. The investigation of marine resources, and particularly the potential of Mexican m...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md18010059
更新日期：2020-01-16 00:00:00
abstract：:Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md9112369
更新日期：2011-01-01 00:00:00
abstract：:Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16030093
更新日期：2018-03-13 00:00:00
abstract：:This work describes the synthesis and biological evaluation of a new heterocyclic hybrid derived from the ellipticine and the marine alkaloid makaluvamine A. Pyridoquinoxalinedione 12 was obtained in seven steps with 6.5% overall yield. 12 and its intermediates 1-11 were evaluated for their in vitro cytotoxic activity...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md13010655
更新日期：2015-01-19 00:00:00
abstract：:Long chain polyunsaturated fatty acids (LC-PUFAs) are important mediators in improving and maintaining human health over the total lifespan. One topic we especially focus on in this review is omega-3 LC-PUFA docosahexaenoic acid (DHA). Adequate DHA levels are essential during neurodevelopment and, in addition, benefic...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12126190
更新日期：2014-12-18 00:00:00
abstract：:The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microor...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md13052924
更新日期：2015-05-13 00:00:00
abstract：:Cancer represents a set of more than 100 diseases, including malignant tumors from different locations. Strategies inducing differentiation have had limited success in the treatment of established cancers. Marine sponges are a biological reservoir of bioactive molecules, especially lectins. Several animal and plant le...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10040727
更新日期：2012-04-01 00:00:00
abstract：:There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030059
更新日期：2017-02-28 00:00:00
abstract：:Organisms lacking external defense mechanisms have developed chemical defense strategies, particularly through the production of secondary metabolites with antibiotic or repellent effects. Secondary metabolites from marine organisms have proven to be an exceptionally rich source of small molecules with pharmacological...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md14010001
更新日期：2015-12-22 00:00:00
abstract：:Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md20080004
更新日期：2008-05-07 00:00:00
abstract：:In the last decades, research has focused on the capabilities of microbes to secrete exopolysaccharides (EPS), because these polymers differ from the commercial ones derived essentially from plants or algae in their numerous valuable qualities. These biopolymers have emerged as new polymeric materials with novel and u...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md12053005
更新日期：2014-05-22 00:00:00
abstract：:The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12052827
更新日期：2014-05-13 00:00:00
abstract：:Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...
journal_title：Marine drugs
pub_type： 杂志文章,评审
doi：10.3390/md15060165
更新日期：2017-06-06 00:00:00
abstract：:A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16050150
更新日期：2018-05-02 00:00:00
abstract：:In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md11030611
更新日期：2013-02-26 00:00:00
abstract：:The Antarctic sponge Dendrilla antarctica is rich in defensive terpenoids with promising antimicrobial potential. Investigation of this demosponge has resulted in the generation of a small chemical library containing diterpenoid secondary metabolites with bioactivity in an infectious disease screening campaign focused...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18060327
更新日期：2020-06-23 00:00:00
abstract：:Cyclic imines are lipophilic marine toxins that bioaccumulate in seafood. Their structure comprises a cyclic-imino moiety, responsible for acute neurotoxicity in mice. Cyclic imines have not been linked yet to human poisonings and are not regulated in Europe, although the European Food Safety Authority requires more d...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md12063706
更新日期：2014-06-23 00:00:00
abstract：:Ten new cembrane-based diterpenes, locrassumins A-G (1-7), (-)-laevigatol B (8), (-)-isosarcophine (9), and (-)-7R,8S-dihydroxydeepoxysarcophytoxide (10), were isolated from a South China Sea collection of the soft coral Lobophytum crassum, together with eight known analogues (11-18). The structures of the new compoun...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md14060111
更新日期：2016-06-03 00:00:00
abstract：:Two new compounds-a trioxilin and a sulfoquinovosyl diacylglycerol (SQDG)-were isolated from the methanolic extract of the heterotrophic dinoflagellate Oxyrrhis marina cultivated by feeding on dried yeasts. The trioxilin was identified as (4Z,8E,13Z,16Z,19Z) -7(S),10(S),11(S)-trihydroxydocosapentaenoic acid (1), and t...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15030057
更新日期：2017-02-27 00:00:00
abstract：:Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10010051
更新日期：2012-01-01 00:00:00
abstract：:Haloferax mediterranei produces C50 carotenoids that have strong antioxidant properties. The response surface methodology (RSM) tool helps to accurately analyze the most suitable conditions to maximize C50 carotenoids production by haloarchaea. The effects of temperature (15⁻50 °C), pH (4-10), and salinity (5⁻28% NaCl...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16100372
更新日期：2018-10-09 00:00:00
abstract：:Viridicatol is a quinoline alkaloid isolated from the deep-sea-derived fungus Penicillium griseofulvum. The structure of viridicatol was unambiguously established by X-ray diffraction analysis. In this study, a mouse model of ovalbumin-induced food allergy and the rat basophil leukemia (RBL)-2H3 cell model were establ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18100517
更新日期：2020-10-16 00:00:00
abstract：:Ice-binding protein (IBPs) protect cells from cryo-injury during cryopreservation by inhibiting ice recrystallization (IR), which is a main cause of cell death. In the present study, we employed two IBPs, one, designated LeIBP from Arctic yeast, and the other, designated FfIBP from Antarctic sea ice bacterium, in the ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md15120372
更新日期：2017-12-01 00:00:00
abstract：:The authors wish to correct Figure 1 in this paper [1] to be as follows:[...]. ...
journal_title：Marine drugs
pub_type： 杂志文章,已发布勘误
doi：10.3390/md15090292
更新日期：2017-09-20 00:00:00
abstract：:Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16040101
更新日期：2018-03-23 00:00:00
abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18020096
更新日期：2020-01-31 00:00:00
abstract：:A general protocol for the asymmetric synthesis of 3-N-arylmethylated right-half model compounds of renieramycins was developed, which enabled structure⁻activity relationship (SAR) study of several 3-N-arylmethyl derivatives. The most active compound (6a) showed significant cytotoxic activity against human prostate ca...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md17010003
更新日期：2018-12-20 00:00:00
abstract：:α-Conotoxin TxID was discovered from Conus textile by gene cloning, which has 4/6 inter-cysteine loop spacing and selectively inhibits α3β4 nicotinic acetylcholine receptor (nAChR) subtype. However, TxID is susceptible to modification due to it containing a methionine (Met) residue that easily forms m...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md16060215
更新日期：2018-06-20 00:00:00
abstract：:Cone snail venoms are considered an untapped reservoir of extremely diverse peptides, named conopeptides, displaying a wide array of pharmacological activities. We report here for the first time, the presence of high molecular weight compounds that participate in the envenomation cocktail used by these marine snails. ...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md10020258
更新日期：2012-02-01 00:00:00
abstract：:The present study investigated the effect of dietary astaxanthin (AX) on the growth performance, antioxidant parameters, and repair of hepatopancreas damage in Pacific white shrimp (Litopenaeus vannamei). To evaluate the hepatopancreas protective function of AX in shrimps, we compared the effect of five isonitrogenous...
journal_title：Marine drugs
pub_type： 杂志文章
doi：10.3390/md18040218
更新日期：2020-04-17 00:00:00
