The Immune Activity of PT-Peptide Derived from Anti-Lipopolysaccharide Factor of the Swimming Crab Portunus trituberculatus Is Enhanced when Encapsulated in Milk-Derived Extracellular Vesicles.

abstract：:Certain strains of cyanobacteria produce a wide array of cyanotoxins, such as microcystins, lyngbyatoxins and aplysiatoxins, that are associated with public health issues. In this pilot study, an approach combining LC-MS/MS and molecular networking was employed as a rapid analytical method to detect aplysiatoxins pres...

journal_title：Marine drugs

authors： Ding CYG,Pang LM,Liang ZX,Goh KKK,Glukhov E,Gerwick WH,Tan LT

更新日期：2018-12-13 00:00:00

abstract：:Sponge-associated bacteria have been mostly cultured from shallow water (≤30 m) sponges, whereas only few studies targeted specimens from below 30 m. This study assessed the cultivability of bacteria from two marine sponges Xestospongia muta and Agelas sventres collected from shallow (<30 m), upper mesophotic (30-60 m...

journal_title：Marine drugs

authors： Indraningrat AAG,Micheller S,Runderkamp M,Sauerland I,Becking LE,Smidt H,Sipkema D

更新日期：2019-10-11 00:00:00

abstract：:Despite the increasing availability of new classes of cancer treatment, such as immune- and targeted therapies, there remains a need for the development of new antiproliferative/cytotoxic drugs with improved pharmacological profiles that can also overcome drug resistant forms of cancer. In this study, we have identifi...

journal_title：Marine drugs

authors： Aldairi AF,Ogundipe OD,Pye DA

更新日期：2018-02-15 00:00:00

abstract：:One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...

journal_title：Marine drugs

authors： Kim Y,Ogura H,Akasaka K,Oikawa T,Matsuura N,Imada C,Yasuda H,Igarashi Y

更新日期：2014-07-08 00:00:00

abstract：:In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...

journal_title：Marine drugs

authors： Franchini A,Malagoli D,Ottaviani E

更新日期：2010-03-16 00:00:00

abstract：:Recently, the studies on the prevention and treatment of human papillomavirus (HPV) which is closely related to the cervical cancer and other genital diseases are attracting more and more attention all over the world. Marine-derived polysaccharides and other bioactive compounds have been shown to possess a variety of ...

journal_title：Marine drugs

authors： Wang SX,Zhang XS,Guan HS,Wang W

更新日期：2014-04-03 00:00:00

abstract：:Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...

journal_title：Marine drugs

authors： Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV

更新日期：2011-01-01 00:00:00

abstract：:Natural O-alkyl-glycerolipids, also known as alkyl-ether-lipids (AEL), feature a long fatty alkyl chain linked to the glycerol unit by an ether bond. AEL are ubiquitously found in different tissues but, are abundant in shark liver oil, breast milk, red blood cells, blood plasma, and bone marrow. Only a few AEL are com...

journal_title：Marine drugs

authors： Pinault M,Guimaraes C,Couthon H,Thibonnet J,Fontaine D,Chantôme A,Chevalier S,Besson P,Jaffrès PA,Vandier C

更新日期：2018-03-23 00:00:00

abstract：:A potent marine toxin, tetrodotoxin (TTX), found in a great variety of marine and some terrestrial species, leaves intriguing questions about its origin and distribution in marine ecosystems. TTX-producing bacteria were found in the cultivable microflora of many TTX-bearing hosts, thereby providing strong support for ...

journal_title：Marine drugs

authors： Melnikova DI,Magarlamov TY

更新日期：2020-03-23 00:00:00

abstract：:A novel, cold-adapted, and acid-base stable manganese superoxide dismutase (Ps-Mn-SOD) was cloned from hadal sea cucumber Paelopatides sp. The dimeric recombinant enzyme exhibited approximately 60 kDa in molecular weight, expressed activity from 0 °C to 70 °C with an optimal temperature of 0 °C, and resisted wide pH v...

journal_title：Marine drugs

authors： Li Y,Kong X,Zhang H

更新日期：2019-02-01 00:00:00

abstract：:A novel wild-type recombinant cold-active α-d-galactosidase (α-PsGal) from the cold-adapted marine bacterium Pseudoalteromonas sp. KMM 701, and its mutants D451A and C494N, were studied in terms of their structural, physicochemical, and catalytic properties. Homology models of the three-dimensional α-PsGal structure, ...

journal_title：Marine drugs

authors： Bakunina I,Slepchenko L,Anastyuk S,Isakov V,Likhatskaya G,Kim N,Tekutyeva L,Son O,Balabanova L

更新日期：2018-09-24 00:00:00

abstract：:Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...

journal_title：Marine drugs

authors： Liu M,Zhao X,Zhao J,Xiao L,Liu H,Wang C,Cheng L,Wu N,Lin X

更新日期：2012-11-21 00:00:00

abstract：:β-N-Methylamino-L-alanine (BMAA), a neurotoxic non-protein amino acid, plays a significant role as an environmental risk factor in neurodegenerative diseases, such as amyotrophic lateral sclerosis. BMAA producers occur globally, colonizing almost all habitats and represent species from distinct phytoplanktonic groups,...

journal_title：Marine drugs

authors： Lage S,Annadotter H,Rasmussen U,Rydberg S

更新日期：2015-03-02 00:00:00

abstract：:High-fat and high-sucrose diet (HFHSD)-induced obesity leads to oxidative stress and chronic inflammatory status. However, little is known about the beneficial effects of total lipids extracted from Spirulina. Hence, in the present study, Spirulina lipids were extracted with chloroform/methanol (SLC) or ethanol (SLE) ...

journal_title：Marine drugs

authors： Yang Y,Du L,Hosokawa M,Miyashita K

更新日期：2020-03-04 00:00:00

abstract：:Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were ...

journal_title：Marine drugs

authors： McCulloch MW,Haltli B,Marchbank DH,Kerr RG

更新日期：2012-08-01 00:00:00

abstract：:The present survey deals with the initial stage of the calcification process in bone and other hard tissues, with special reference to the organic-inorganic relationship and the transformation that the early inorganic particles undergo as the process moves towards completion. Electron microscope studies clearly exclud...

journal_title：Marine drugs

authors： Bonucci E

更新日期：2014-07-23 00:00:00

abstract：:Microalgae oil is an optimal feedstock for nutraceutical, pharmaceutical and biodiesel production, but its high levels of chlorophyll limit its large-scale application. To date, few effective approaches have been developed to remove chlorophyll from microalgae oil. The main purpose of this study was to present a prepr...

journal_title：Marine drugs

authors： Li T,Xu J,Wu H,Wang G,Dai S,Fan J,He H,Xiang W

更新日期：2016-09-07 00:00:00

abstract：:The striking rise of methicillin-resistant Staphylococcus aureus (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant Myoporum bontioides A. Gray, w...

journal_title：Marine drugs

authors： Dong LM,Huang LL,Dai H,Xu QL,Ouyang JK,Jia XC,Gu WX,Tan JW

更新日期：2018-11-08 00:00:00

abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...

journal_title：Marine drugs

authors： Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu K

更新日期：2017-05-18 00:00:00

abstract：:The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

journal_title：Marine drugs

authors： Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

更新日期：2018-11-16 00:00:00

abstract：:A marine-derived strain of Clonostachys rosea isolated from sediments of the river Loire estuary (France) was investigated for its high lipid production. The fungal strain was grown on six different culture media to explore lipid production changes. An original branched conjugated fatty acid, mainly present in triglyc...

journal_title：Marine drugs

authors： Dias AC,Ruiz N,Couzinet-Mossion A,Bertrand S,Duflos M,Pouchus YF,Barnathan G,Nazih H,Wielgosz-Collin G

更新日期：2015-08-06 00:00:00

abstract：:Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E...

journal_title：Marine drugs

authors： Kim J,Shin D,Kim SH,Park W,Shin Y,Kim WK,Lee SK,Oh KB,Shin J,Oh DC

更新日期：2017-06-06 00:00:00

abstract：:The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...

journal_title：Marine drugs

authors： Yoshida K,Hashimoto M,Hori R,Adachi T,Okuyama H,Orikasa Y,Nagamine T,Shimizu S,Ueno A,Morita N

更新日期：2016-05-12 00:00:00

abstract：:Early acute kidney injury (AKI) is a devastating complication in critical burn patients, and it is associated with severe morbidity and mortality. The mechanism of AKI is multifactorial. Astaxanthin (ATX) is a natural compound that is widely distributed in marine organisms; it is a strong antioxidant and exhibits othe...

journal_title：Marine drugs

authors： Guo SX,Zhou HL,Huang CL,You CG,Fang Q,Wu P,Wang XG,Han CM

更新日期：2015-04-13 00:00:00

abstract：:Nowadays, various drugs on the market are becoming more and more resistant to numerous diseases, thus declining their efficacy for treatment purposes in human beings. Antibiotic resistance is one among the top listed threat around the world which eventually urged the discovery of new potent drugs followed by an increa...

journal_title：Marine drugs

authors： Shah SAA,Akhter N,Auckloo BN,Khan I,Lu Y,Wang K,Wu B,Guo YW

更新日期：2017-11-10 00:00:00

abstract：:Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...

journal_title：Marine drugs

authors： Dong LY,Jin J,Lu G,Kang XL

更新日期：2013-03-21 00:00:00

abstract：:A series of novel marinopyrroles with sulfide and sulphone spacers were designed and synthesized. Their activity to disrupt the binding of the pro-apoptotic protein, Bim, to the pro-survival proteins, Mcl-1 and Bcl-xL, was evaluated using ELISA assays. Fluorescence-quenching (FQ) assays confirmed the direct binding of...

journal_title：Marine drugs

authors： Cheng C,Liu Y,Balasis ME,Garner TP,Li J,Simmons NL,Berndt N,Song H,Pan L,Qin Y,Nicolaou KC,Gavathiotis E,Sebti SM,Li R

更新日期：2014-07-29 00:00:00

abstract：:Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...

journal_title：Marine drugs

authors： Tareq FS,Lee MA,Lee HS,Lee JS,Lee YJ,Shin HJ

更新日期：2014-01-31 00:00:00

abstract：:Two new cyclotetrapeptides, sartoryglabramides A (5) and B (6), and a new analog of fellutanine A (8) were isolated, together with six known compounds including ergosta-4, 6, 8 (14), 22-tetraen-3-one, ergosterol 5, 8-endoperoxide, helvolic acid, aszonalenin (1), (3R)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodia...

journal_title：Marine drugs

authors： May Zin WW,Buttachon S,Dethoup T,Fernandes C,Cravo S,Pinto MM,Gales L,Pereira JA,Silva AM,Sekeroglu N,Kijjoa A

更新日期：2016-07-20 00:00:00

abstract：:Ulvan lyases can degrade ulvan to oligosaccharides with potent biological activity. A new ulvan lyase gene, ALT3695, was identified in Alteromonas sp. A321. Soluble expression of ALT3695 was achieved in Escherichia coli BL21 (DE3). The 1314-bp gene encoded a protein with 437 amino acid residues. The amino acid sequenc...

journal_title：Marine drugs

authors： Gao J,Du C,Chi Y,Zuo S,Ye H,Wang P

更新日期：2019-10-08 00:00:00