Borrelidins C-E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp.

Abstract:

:Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E, which are new members of the rare borrelidin class of antibiotics, were elucidated by NMR, mass, IR, and UV spectroscopic analyses. The configurations of borrelidines C-E were determined by the interpretation of ROESY NMR spectra, J-based configuration analysis, a modified Mosher's method, and CD spectroscopic analysis. Borrelidins C and D displayed inhibitory activity, particularly against the Gram-negative pathogen Salmonella enterica, and moderate cytotoxicity against the SNU638 and K562 carcinoma cell lines.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Kim J,Shin D,Kim SH,Park W,Shin Y,Kim WK,Lee SK,Oh KB,Shin J,Oh DC

doi

10.3390/md15060166

subject

Has Abstract

pub_date

2017-06-06 00:00:00

issue

6

issn

1660-3397

pii

md15060166

journal_volume

15

pub_type

杂志文章
  • Xeniaphyllane-Derived Terpenoids from Soft Coral Sinularia nanolobata.

    abstract::A novel tetranorditerpenoid, sinubatin A (1) (having an unprecedented carbon skeleton), a new norditerpenoid, sinubatin B (2) (a 4,5-epoxycaryophyllene possessing an unusual methylfuran moiety side chain), and a known diterpenoid, gibberosin J (3) were isolated from soft coral Sinulariananolobata. The structures of th...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16020040

    authors: Hsu FY,Wang SK,Duh CY

    更新日期:2018-01-24 00:00:00

  • Comparative Analysis of Culture Conditions for the Optimization of Carotenoid Production in Several Strains of the Picoeukaryote Ostreococcus.

    abstract::Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16030076

    authors: Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

    更新日期:2018-02-28 00:00:00

  • Ascidian Toxins with Potential for Drug Development.

    abstract::Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of the...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md16050162

    authors: Watters DJ

    更新日期:2018-05-13 00:00:00

  • Induction of apoptosis, G₀/G₁ phase arrest and microtubule disassembly in K562 leukemia cells by Mere15, a novel polypeptide from Meretrix meretrix Linnaeus.

    abstract::Mere15 is a novel polypeptide from Meretrix meretrix Linnaeus with cytotoxicity in solid cancer cells. In this study, we investigated its activity on human K562 chronic myelogenous leukemia cells. Mere15 inhibited the growth of K562 cells with IC₅₀ values of 38.2 μg/mL. Mere15 also caused concentration dependent induc...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md10112596

    authors: Liu M,Zhao X,Zhao J,Xiao L,Liu H,Wang C,Cheng L,Wu N,Lin X

    更新日期:2012-11-21 00:00:00

  • The deep-sea natural products, biogenic polyphosphate (Bio-PolyP) and biogenic silica (Bio-Silica), as biomimetic scaffolds for bone tissue engineering: fabrication of a morphogenetically-active polymer.

    abstract::Bone defects in human, caused by fractures/nonunions or trauma, gain increasing impact and have become a medical challenge in the present-day aging population. Frequently, those fractures require surgical intervention which ideally relies on autografts or suboptimally on allografts. Therefore, it is pressing and likew...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md11030718

    authors: Wang X,Schröder HC,Feng Q,Draenert F,Müller WE

    更新日期:2013-03-08 00:00:00

  • Functional metabolomics uncovers metabolic alterations associated to severe oxidative stress in MCF7 breast cancer cells exposed to ascididemin.

    abstract::Marine natural products are a source of promising agents for cancer treatment. However, there is a need to improve the evaluation of their mechanism of action in tumors. Metabolomics of the response to anti-tumor agents is a tool to reveal candidate biomarkers and metabolic targets. We used two-dimensional high-resolu...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md11103846

    authors: Morvan D

    更新日期:2013-10-11 00:00:00

  • Physicochemical and Functional Properties of Type I Collagens in Red Stingray (Dasyatis akajei) Skin.

    abstract::Collagen is widely used in the pharmaceutical, tissue engineering, nutraceutical, and cosmetic industries. In this study, acid-soluble collagen (ASC) and pepsin-soluble collagen (PSC) were extracted from the skin of red stingray, and its physicochemical and functional properties were investigated. The yields of ASC an...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17100558

    authors: Chen J,Li J,Li Z,Yi R,Shi S,Wu K,Li Y,Wu S

    更新日期:2019-09-28 00:00:00

  • Fucoidan and Fucosylated Chondroitin Sulfate Stimulate Hematopoiesis in Cyclophosphamide-Induced Mice.

    abstract::Application of cytostatics in cancer patients' chemotherapy results in a number of side effects, including the inhibition of various parts of hematopoiesis. Two sulfated polysaccharides, fucoidan from the seaweed Chordaria flagelliformis (PS-Fuc) and fucosylated chondroitin sulfate from the sea cucumber Massinium magn...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15100301

    authors: Anisimova N,Ustyuzhanina N,Bilan M,Donenko F,Usov A,Kiselevskiy M,Nifantiev N

    更新日期:2017-09-30 00:00:00

  • Cephalopods as vectors of harmful algal bloom toxins in marine food webs.

    abstract::Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md11093381

    authors: Lopes VM,Lopes AR,Costa P,Rosa R

    更新日期:2013-09-06 00:00:00

  • A Place to Call Home: An Analysis of the Bacterial Communities in Two Tethya rubra Samaai and Gibbons 2005 Populations in Algoa Bay, South Africa.

    abstract::Sponges are important sources of bioactive secondary metabolites. These compounds are frequently synthesized by bacterial symbionts, which may be recruited from the surrounding seawater or transferred to the sponge progeny by the parent. In this study, we investigated the bacterial communities associated with the spon...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15040095

    authors: Waterworth SC,Jiwaji M,Kalinski JJ,Parker-Nance S,Dorrington RA

    更新日期:2017-03-25 00:00:00

  • Gliotoxin Inhibits Proliferation and Induces Apoptosis in Colorectal Cancer Cells.

    abstract::The discovery of new bioactive compounds from marine natural sources is very important in pharmacological research. Here we developed a Wnt responsive luciferase reporter assay to screen small molecule inhibitors of cancer associated constitutive Wnt signaling pathway. We identified that gliotoxin (GTX) and some of it...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md13106259

    authors: Chen J,Wang C,Lan W,Huang C,Lin M,Wang Z,Liang W,Iwamoto A,Yang X,Liu H

    更新日期:2015-10-02 00:00:00

  • Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects.

    abstract::Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chito...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md17080452

    authors: Schmitz C,Auza LG,Koberidze D,Rasche S,Fischer R,Bortesi L

    更新日期:2019-08-01 00:00:00

  • Anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of nitroastaxanthin and nitrolutein, the reaction products of astaxanthin and lutein with peroxynitrite.

    abstract::Astaxanthin captured peroxynitrite to form nitroastaxanthins. 15-Nitroastaxanthin was a major reaction product of astaxanthin with peroxynitrite. Here, the anti-oxidative, anti-tumor-promoting, and anti-carcinogensis activities of 15-nitroastaxanthin were investigated. In addition to astaxanthin, 15-nitroastaxanthin s...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md10061391

    authors: Maoka T,Tokuda H,Suzuki N,Kato H,Etoh H

    更新日期:2012-06-01 00:00:00

  • Different Antifungal Activity of Anabaena sp., Ecklonia sp., and Jania sp. against Botrytis cinerea.

    abstract::Water extracts and polysaccharides from Anabaena sp., Ecklonia sp., and Jania sp. were tested for their activity against the fungal plant pathogen Botrytis cinerea. Water extracts at 2.5, 5.0, and 10.0 mg/mL inhibited B. cinerea growth in vitro. Antifungal activity of polysaccharides obtained by N-cetylpyridinium brom...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17050299

    authors: Righini H,Baraldi E,García Fernández Y,Martel Quintana A,Roberti R

    更新日期:2019-05-20 00:00:00

  • Targets and effects of yessotoxin, okadaic acid and palytoxin: a differential review.

    abstract::In this review, we focus on processes, organs and systems targeted by the marine toxins yessotoxin (YTX), okadaic acid (OA) and palytoxin (PTX). The effects of YTX and their basis are analyzed from data collected in the mollusc Mytilus galloprovincialis, the annelid Enchytraeus crypticus, Swiss CD1 mice and invertebra...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md8030658

    authors: Franchini A,Malagoli D,Ottaviani E

    更新日期:2010-03-16 00:00:00

  • Synthesis and Evaluation of Spumigin Analogues Library with Thrombin Inhibitory Activity.

    abstract::Spumigins are marine natural products derived from cyanobacteria Nodulariaspumigena, which mimics the structure of the d-Phe-Pro-Arg sequence and is crucial for binding to the active site of serine proteases thrombin and factor Xa. Biological evaluation of spumigins showed that spumigins with a (2S,4S)-4-methylproline...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md16110413

    authors: Žula A,Będziak I,Kikelj D,Ilaš J

    更新日期:2018-10-27 00:00:00

  • Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.

    abstract::Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md11125130

    authors: Kumar SR,Hosokawa M,Miyashita K

    更新日期:2013-12-16 00:00:00

  • Identification and characterization of an anti-fibrotic benzopyran compound isolated from mangrove-derived Streptomyces xiamenensis.

    abstract::An anti-fibrotic compound produced by Streptomycesn xiamenensis, found in mangrove sediments, was investigated for possible therapeutic effects against fibrosis. The compound, N-[[3,4-dihydro-3S-hydroxy-2S-methyl-2-(4'R-methyl-3'S-pentenyl)-2H-1-benzopyran-6-yl]carbonyl]-threonine (1), was isolated from crude extracts...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md10030639

    authors: Xu MJ,Liu XJ,Zhao YL,Liu D,Xu ZH,Lang XM,Ao P,Lin WH,Yang SL,Zhang ZG,Xu J

    更新日期:2012-03-01 00:00:00

  • Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations.

    abstract::Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery. However, there remain important biological and practical problems that can complicate or obscure biosynthetic analysis in genomic and metagenomic sequencing pr...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md15060165

    authors: Miller IJ,Chevrette MG,Kwan JC

    更新日期:2017-06-06 00:00:00

  • Brown Algae Padina sanctae-crucis Børgesen: A Potential Nutraceutical.

    abstract::Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15100251

    authors: Nogueira RBSS,Tomaz ACA,Pessoa DR,Xavier AL,Pita JCLR,Sobral MV,Pontes MLC,Pessôa HLF,Diniz MFFM,Miranda GEC,Vieira MAR,Marques MOM,Souza MFV,Cunha EVL

    更新日期:2017-09-26 00:00:00

  • Optimization of Collagenase Production by Pseudoalteromonas sp. SJN2 and Application of Collagenases in the Preparation of Antioxidative Hydrolysates.

    abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15120377

    authors: Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

    更新日期:2017-12-04 00:00:00

  • Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether, a marine algae derived bromophenol, inhibits the growth of Botrytis cinerea and interacts with DNA molecules.

    abstract::Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md12073838

    authors: Liu M,Wang G,Xiao L,Xu X,Liu X,Xu P,Lin X

    更新日期:2014-06-27 00:00:00

  • Impact of ocean acidification on energy metabolism of oyster, Crassostrea gigas--changes in metabolic pathways and thermal response.

    abstract::Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md8082318

    authors: Lannig G,Eilers S,Pörtner HO,Sokolova IM,Bock C

    更新日期:2010-08-11 00:00:00

  • 4-Acetoxydolastane diterpene from the Brazilian brown alga Canistrocarpus cervicornis as antileishmanial agent.

    abstract::Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md9112369

    authors: Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV

    更新日期:2011-01-01 00:00:00

  • From Marine Venoms to Drugs: Efficiently Supported by a Combination of Transcriptomics and Proteomics.

    abstract::The potential of marine natural products to become new drugs is vast; however, research is still in its infancy. The chemical and biological diversity of marine toxins is immeasurable and as such an extraordinary resource for the discovery of new drugs. With the rapid development of next-generation sequencing (NGS) an...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审

    doi:10.3390/md15040103

    authors: Xie B,Huang Y,Baumann K,Fry BG,Shi Q

    更新日期:2017-03-30 00:00:00

  • Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in Paclitaxel-Resistant Ovarian Cancer Cells.

    abstract::Death-associated protein kinase 1 (DAPK1) expression induced by diverse death stimuli mediates apoptotic activity in various cancers, including ovarian cancer. In addition, mutual interaction between the tumor suppressor p53 and DAPK1 influences survival and death in several cancer cell lines. However, the exact role ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17070412

    authors: Park GB,Jeong JY,Kim D

    更新日期:2019-07-12 00:00:00

  • Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11.

    abstract::Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinol...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md17080446

    authors: Yu J,Han H,Zhang X,Ma C,Sun C,Che Q,Gu Q,Zhu T,Zhang G,Li D

    更新日期:2019-07-28 00:00:00

  • Anti-Neuroinflammatory Agent, Restricticin B, from the Marine-Derived Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells.

    abstract::A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D ...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18090465

    authors: Choi BK,Jo SH,Choi DK,Trinh PTH,Lee HS,Cao VA,Van TTT,Shin HJ

    更新日期:2020-09-14 00:00:00

  • The Epiphytic Genus Gambierdiscus (Dinophyceae) in the Kermadec Islands and Zealandia Regions of the Southwestern Pacific and the Associated Risk of Ciguatera Fish Poisoning.

    abstract::Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md15070219

    authors: Rhodes LL,Smith KF,Murray S,Harwood DT,Trnski T,Munday R

    更新日期:2017-07-11 00:00:00

  • Sargassum horneri as a Functional Food Ameliorated IgE/BSA-Induced Mast Cell Activation and Passive Cutaneous Anaphylaxis in Mice.

    abstract::Sargassum horneri (S. horneri), an edible brown alga, has been proposed as a functional food with an improvement effect on abnormal skin immune responses. The present study investigates the anti-allergic effect of an ethanol extract from S. horneri (SHE) on immunoglobulin E (IgE)/bovine serum albumin (BSA)-mediated ac...

    journal_title:Marine drugs

    pub_type: 杂志文章

    doi:10.3390/md18120594

    authors: Han EJ,Kim HS,Sanjeewa KKA,Jung K,Jee Y,Jeon YJ,Fernando IPS,Ahn G

    更新日期:2020-11-26 00:00:00