Abstract：
:Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆⁸ rather than the normal cembranoid-∆¹ unit in the endo-Diels-Alder cycloaddition. Compounds 2 and 3 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC50 values being at 18.2 and 32.5 μM, respectively.
journal_name
Mar Drugsjournal_title
Marine drugsauthors
Li W,Zou YH,Ge MX,Lou LL,Xu YS,Ahmed A,Chen YY,Zhang JS,Tang GH,Yin Sdoi
10.3390/md15040085subject
Has Abstractpub_date
2017-03-23 00:00:00issue
4issn
1660-3397pii
md15040085journal_volume
15pub_type
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