Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in Paclitaxel-Resistant Ovarian Cancer Cells.

abstract：:Natural marine products have shown an interesting array of diverse and novel chemical structures with potent biological activities. Our study reports the antiproliferative assays of crude extracts, fraction and pure compound (4R,9S,14S)-4α-acetoxy-9β,14α-dihydroxydolast-1(15),7-diene (1) obtained from brown alga Canis...

journal_title：Marine drugs

authors： Dos Santos AO,Britta EA,Bianco EM,Ueda-Nakamura T,Filho BP,Pereira RC,Nakamura CV

更新日期：2011-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer mortality worldwide and non-small-cell lung cancer (NSCLC) is the most common type. Marine plants provide rich resources for anticancer drug discovery. Fucoxanthin (FX), a Laminaria japonica extract, has attracted great research interest for its antitumor activities. Accumula...

journal_title：Marine drugs

authors： Mei C,Zhou S,Zhu L,Ming J,Zeng F,Xu R

更新日期：2017-02-15 00:00:00

abstract：:Polysaccharides extracted from marine algae have attracted much attention due to their biotechnological applications, including therapeutics, cosmetics, and mainly in agriculture and horticulture as biostimulants, biofertilizers, and stimulators of the natural defenses of plants. This study aimed to evaluate the abili...

journal_title：Marine drugs

authors： Aitouguinane M,Bouissil S,Mouhoub A,Rchid H,Fendri I,Abdelkafi S,Ould El-Hadj MD,Boual Z,Dubessay P,Gardarin C,Michaud P,El Alaoui-Talibi Z,El Modafar C,Pierre G,Delattre C

更新日期：2020-10-19 00:00:00

abstract：:Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic ana...

journal_title：Marine drugs

authors： Ragini K,Piggott AM,Karuso P

更新日期：2017-06-15 00:00:00

abstract：:Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...

journal_title：Marine drugs

authors： Pateiro M,Munekata PES,Domínguez R,Wang M,Barba FJ,Bermúdez R,Lorenzo JM

更新日期：2020-02-04 00:00:00

abstract：:Two new cyclotetrapeptides, sartoryglabramides A (5) and B (6), and a new analog of fellutanine A (8) were isolated, together with six known compounds including ergosta-4, 6, 8 (14), 22-tetraen-3-one, ergosterol 5, 8-endoperoxide, helvolic acid, aszonalenin (1), (3R)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodia...

journal_title：Marine drugs

authors： May Zin WW,Buttachon S,Dethoup T,Fernandes C,Cravo S,Pinto MM,Gales L,Pereira JA,Silva AM,Sekeroglu N,Kijjoa A

更新日期：2016-07-20 00:00:00

abstract：:Topical administration of drugs into the vagina can provide local therapy of vaginal infections, preventing the possible systemic side effects of the drugs. The natural polysaccharide chitosan is known for its excellent mucoadhesive properties, safety profile, and antibacterial effects, and thus it can be utilized in ...

journal_title：Marine drugs

authors： Jøraholmen MW,Bhargava A,Julin K,Johannessen M,Škalko-Basnet N

更新日期：2020-01-31 00:00:00

abstract：:Magnetotactic bacteria (MTB) produce intracellular organelles called magnetosomes which are magnetic nanoparticles composed of magnetite (Fe3O4) or greigite (Fe3S4) enveloped by a lipid bilayer. The synthesis of a magnetosome is through a genetically controlled process in which the bacterium has control over the compo...

journal_title：Marine drugs

authors： Araujo AC,Abreu F,Silva KT,Bazylinski DA,Lins U

更新日期：2015-01-16 00:00:00

abstract：:Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...

journal_title：Marine drugs

authors： Ngokpol S,Suwakulsiri W,Sureram S,Lirdprapamongkol K,Aree T,Wiyakrutta S,Mahidol C,Ruchirawat S,Kittakoop P

更新日期：2015-06-05 00:00:00

abstract：:Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute con...

journal_title：Marine drugs

authors： Liu Z,Fan Z,Sun Z,Liu H,Zhang W

更新日期：2019-10-23 00:00:00

abstract：:Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...

journal_title：Marine drugs

authors： Lannig G,Eilers S,Pörtner HO,Sokolova IM,Bock C

更新日期：2010-08-11 00:00:00

abstract：:Microorganisms that inhabit unchartered unique soil such as in the highly saline and hot Red Sea lagoons on the Saudi Arabian coastline, represent untapped sources of potentially new bioactive compounds. In this study, a culture-dependent approach was applied to three types of sediments: mangrove mud (MN), microbial m...

journal_title：Marine drugs

authors： Al-Amoudi S,Essack M,Simões MF,Bougouffa S,Soloviev I,Archer JA,Lafi FF,Bajic VB

更新日期：2016-09-10 00:00:00

abstract：:Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable anti...

journal_title：Marine drugs

authors： Xie X,Chen Q,Tao J

更新日期：2018-04-05 00:00:00

abstract：:Chitosan is sensitive to environmental pH values due to its electric property. This study investigates whether the pH-responsive chitosan assay can provide a simple method to evaluate the aggressive behavior of cancer cells with cell detachment ratio. The epithelial-mesenchymal transition (EMT) is induced with transfo...

journal_title：Marine drugs

authors： Yen CH,Young TH,Hsieh MC,Liao LJ,Huang TW

更新日期：2019-11-23 00:00:00

abstract：:Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chito...

journal_title：Marine drugs

authors： Schmitz C,Auza LG,Koberidze D,Rasche S,Fischer R,Bortesi L

更新日期：2019-08-01 00:00:00

abstract：:Gut microbiota has been proved to be an indispensable link between nutrient excess and metabolic syndrome, and chitin oligosaccharide (NACOS) has displayed therapeutic effects on multiple diseases such as cancer and gastritis. In this study, we aim to confirm whether NACOS can ameliorate high-fat diet (HFD)-induced me...

journal_title：Marine drugs

authors： Zheng J,Cheng G,Li Q,Jiao S,Feng C,Zhao X,Yin H,Du Y,Liu H

更新日期：2018-02-19 00:00:00

abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

journal_title：Marine drugs

authors： Zhang W,Sun T,Ma Z,Li Y

更新日期：2014-04-22 00:00:00

abstract：:The study of spatial distribution of secondary metabolites within microbial cells facilitates the screening of candidate strains from marine environments for functional metabolites and allows for the subsequent assessment of the production of metabolites, such as antibiotics. This paper demonstrates the first applicat...

journal_title：Marine drugs

authors： Miyaoka R,Hosokawa M,Ando M,Mori T,Hamaguchi HO,Takeyama H

更新日期：2014-05-13 00:00:00

abstract：:In this study, the extraction conditions of the crude polysaccharide from Cereus sinensis were optimized by response surface methodology. The optimum extraction conditions were: a ratio of raw material to water volume of 1:80 (g/mL); an extraction temperature of 72 °C; and an extraction time of 3 h. Then, a purified p...

journal_title：Marine drugs

authors： Wu J,Zhou X,Zhang M,Yao Y,Han J,Liu K

更新日期：2017-05-18 00:00:00

abstract：:AIDS is a pandemic responsible for more than 35 million deaths. The emergence of resistant mutations due to drug use is the biggest cause of treatment failure. Marine organisms are sources of different molecules, some of which offer promising HIV-1 reverse transcriptase (RT) inhibitory activity, such as the diterpenes...

journal_title：Marine drugs

authors： Miceli LA,Teixeira VL,Castro HC,Rodrigues CR,Mello JF,Albuquerque MG,Cabral LM,de Brito MA,de Souza AM

更新日期：2013-10-29 00:00:00

abstract：:Notably, α-conotoxins with carboxy-terminal (C-terminal) amidation are inhibitors of the pentameric nicotinic acetylcholine receptors (nAChRs), which are therapeutic targets for neurological diseases and disorders. The (α3)2(β2)3 nAChR subunit arrangement comprises a pair of α3(+)β2(-) and β2(+)α3(-) interfaces, and a...

journal_title：Marine drugs

authors： Wen J,Adams DJ,Hung A

更新日期：2020-07-03 00:00:00

abstract：:Concerning the requirements of effective drug candidates to combat against high rising multidrug resistant pathogens, we isolated three new linear lipopeptides, gageostatins A-C (1-3), consisting of hepta-peptides and new 3-β-hydroxy fatty acids from the fermentation broth of a marine-derived bacterium Bacillus subtil...

journal_title：Marine drugs

authors： Tareq FS,Lee MA,Lee HS,Lee JS,Lee YJ,Shin HJ

更新日期：2014-01-31 00:00:00

abstract：:Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

journal_title：Marine drugs

authors： Kumar SR,Hosokawa M,Miyashita K

更新日期：2013-12-16 00:00:00

abstract：:Chlorophenols (CPs) are environmental pollutants that are produced through various anthropogenic activities and introduced in the environment. Living organisms, including humans, are exposed to these toxic xenobiotics and suffer from adverse health effects. More specifically, 2,4-dichlorophenol (2,4-DCP) is released i...

journal_title：Marine drugs

authors： Nikolaivits E,Agrafiotis A,Termentzi A,Machera K,Le Goff G,Álvarez P,Chavanich S,Benayahu Y,Ouazzani J,Fokialakis N,Topakas E

更新日期：2019-09-30 00:00:00

abstract：:Chondroitinase (ChSase), a type of glycosaminoglycan (GAG) lyase, can degrade chondroitin sulfate (CS) to unsaturate oligosaccharides, with various functional activities. In this study, ChSase AC II from a newly isolated marine bacterium Arthrobacter sp. CS01 was cloned, expressed in Pichia pastoris X33, purified, and...

journal_title：Marine drugs

authors： Fang Y,Yang S,Fu X,Xie W,Li L,Liu Z,Mou H,Zhu C

更新日期：2019-03-20 00:00:00

abstract：:Three myxobacterial strains, designated SWB004, SWB005 and SWB006, were obtained from beach sand samples from the Pacific Ocean and the North Sea. The strains were cultivated in salt water containing media and subjected to studies to determine their taxonomic status, the presence of genes for the biosynthesis of polyk...

journal_title：Marine drugs

authors： Schäberle TF,Goralski E,Neu E,Erol O,Hölzl G,Dörmann P,Bierbaum G,König GM

更新日期：2010-09-03 00:00:00

abstract：:Two new sulfoxide-containing metabolites, aplisulfamines A and B, have been isolated from an Aplidium sp. collected in the Bay of Naples. Their planar structure and geometry of a double bond were readily determined by using standard methods, mainly NMR spectroscopy. An original approach was used to assign the absolute...

journal_title：Marine drugs

authors： Aiello A,Fattorusso E,Imperatore C,Luciano P,Menna M,Vitalone R

更新日期：2012-01-01 00:00:00

abstract：:When the aquaculture water environment deteriorates or the temperature rises, shrimp are susceptible to viral or bacterial infections, causing a large number of deaths. This study comprehensively evaluated the effects of the oral administration of a chitosan-gentamicin conjugate (CS-GT) after Litopenaeus vannamei were...

journal_title：Marine drugs

authors： Liang F,Li C,Hou T,Wen C,Kong S,Ma D,Sun C,Li S

更新日期：2020-08-10 00:00:00

abstract：:Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...

journal_title：Marine drugs

authors： Lopes VR,Fernández N,Martins RF,Vasconcelos V

更新日期：2010-03-05 00:00:00

abstract：:Immunotherapy takes advantage of the immune system to prevent, control, and eliminate neoplastic cells. The research in the field has already led to major breakthroughs to treat cancer. In this work, we describe a platform that integrates in vitro bioassays to test the immune response and direct antitumor effects for ...

journal_title：Marine drugs

authors： Gallo C,Barra G,Saponaro M,Manzo E,Fioretto L,Ziaco M,Nuzzo G,d'Ippolito G,De Palma R,Fontana A

更新日期：2020-11-29 00:00:00