Physical Properties, Chemical Analysis, and Evaluation of Antimicrobial Response of New Polylactide/Alginate/Copper Composite Materials.


:In recent years, due to an expansion of antibiotic-resistant microorganisms, there has been growing interest in biodegradable and antibacterial polymers that can be used in selected biomedical applications. The present work describes the synthesis of antimicrobial polylactide-copper alginate (PLA-ALG-Cu2+) composite fibers and their characterization. The composites were prepared by immersing PLA fibers in aqueous solution of sodium alginate, followed by ionic cross-linking of alginate chains within the polylactide fibers with Cu(II) ions to yield PLA-ALG-Cu2+ composite fibers. The composites, so prepared, were characterized by scanning electron microscopy (SEM), UV/VIS transmittance and attenuated total reflection Fourier-transform infrared spectroscopy ATR-FTIR, and by determination of their specific surface area (SSA), total/average pore volumes (through application of the 5-point Brunauer-Emmett-Teller method (BET)), and ability to block UV radiation (determination of the ultraviolet protection factor (UPF) of samples). The composites were also subjected to in vitro antimicrobial activity evaluation tests against colonies of Gram-negative (E. coli) and Gram-positive (S. aureus) bacteria and antifungal susceptibility tests against Aspergillus niger and Chaetomium globosum fungal mold species. All the results obtained in this work showed that the obtained composites were promising materials to be used as an antimicrobial wound dressing.


Mar Drugs


Marine drugs


Kudzin MH,Boguń M,Mrozińska Z,Kaczmarek A




Has Abstract


2020-12-21 00:00:00










  • Krill Oil-In-Water Emulsion Protects against Lipopolysaccharide-Induced Proinflammatory Activation of Macrophages In Vitro.

    abstract:BACKGROUND:Parenteral nutrition is often a mandatory therapeutic strategy for cases of septicemia. Likewise, therapeutic application of anti-oxidants, anti-inflammatory therapy, and endotoxin lowering, by removal or inactivation, might be beneficial to ameliorate the systemic inflammatory response during the acute phas...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bonaterra GA,Driscoll D,Schwarzbach H,Kinscherf R

    更新日期:2017-03-15 00:00:00

  • A Collection of Bioactive Nitrogen-Containing Molecules from the Marine Sponge Acanthostrongylophora ingens.

    abstract::Thirteen nitrogen-containing molecules (1a/1b and 2-12) were isolated from the Indonesian sponge Acanthostrongylophora ingens, highlighting the richness of this organism as a source of alkaloids. Their structures were elucidated using one- and two-dimensional NMR spectroscopy and HR-ESI-MS, while the stereochemistry o...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Esposito G,Mai LH,Longeon A,Mangoni A,Durieu E,Meijer L,Van Soest R,Costantino V,Bourguet-Kondracki ML

    更新日期:2019-08-15 00:00:00

  • Natural and semisynthetic analogues of manadoperoxide B reveal new structural requirements for trypanocidal activity.

    abstract::Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Chianese G,Scala F,Calcinai B,Cerrano C,Dien HA,Kaiser M,Tasdemir D,Taglialatela-Scafati O

    更新日期:2013-08-28 00:00:00

  • New ikarugamycin derivatives with antifungal and antibacterial properties from Streptomyces zhaozhouensis.

    abstract::A bioassay guided fractionation of the ethyl acetate extract from culture broths of the strain Streptomyces zhaozhouensis CA-185989 led to the isolation of three new polycyclic tetramic acid macrolactams (1-3) and four known compounds. All the new compounds were structurally related to the known Streptomyces metabolit...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lacret R,Oves-Costales D,Gómez C,Díaz C,de la Cruz M,Pérez-Victoria I,Vicente F,Genilloud O,Reyes F

    更新日期:2014-12-29 00:00:00

  • Dechdigliotoxins A-C, Three Novel Disulfide-Bridged Gliotoxin Dimers from Deep-Sea Sediment Derived Fungus Dichotomomyces cejpii.

    abstract::Dechdigliotoxins A-C (1-3), which represented the first examples of gliotoxin dimers with an unprecedented exocyclic disulfide linkage, were obtained from a deep-sea derived fungus Dichotomomyces cejpii FS110. The structures of these compounds were elucidated on the basis of spectroscopic analysis and the absolute con...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Liu Z,Fan Z,Sun Z,Liu H,Zhang W

    更新日期:2019-10-23 00:00:00

  • Fishery Wastes as a Yet Undiscovered Treasure from the Sea: Biomolecules Sources, Extraction Methods and Valorization.

    abstract::The search for new biological sources of commercial value is a major goal for the sustainable management of natural resources. The huge amount of fishery by-catch or processing by-products continuously produced needs to be managed to avoid environmental problems and keep resource sustainability. Fishery by-products ca...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Caruso G,Floris R,Serangeli C,Di Paola L

    更新日期:2020-12-07 00:00:00

  • Phlorofucofuroeckol A from Edible Brown Alga Ecklonia Cava Enhances Osteoblastogenesis in Bone Marrow-Derived Human Mesenchymal Stem Cells.

    abstract::The deterioration of bone formation is a leading cause of age-related bone disorders. Lack of bone formation is induced by decreased osteoblastogenesis. In this study, osteoblastogenesis promoting effects of algal phlorotannin, phlorofucofuroeckol A (PFF-A), were evaluated. PFF-A was isolated from brown alga Eckloniac...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Oh JH,Ahn BN,Karadeniz F,Kim JA,Lee JI,Seo Y,Kong CS

    更新日期:2019-09-21 00:00:00

  • Deciphering Molecular Mechanism of the Neuropharmacological Action of Fucosterol through Integrated System Pharmacology and In Silico Analysis.

    abstract::Fucosterol is an algae-derived unique phytosterol having several medicinal properties, including antioxidant, anti-inflammatory, anticholinesterase, neuroprotective, and so on. Accumulated evidence suggests a therapeutic promise of fucosterol in neurodegeneration; however, the in-depth pharmacological mechanism of its...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hannan MA,Dash R,Sohag AAM,Moon IS

    更新日期:2019-11-13 00:00:00

  • Antithrombotics from the Sea: Polysaccharides and Beyond.

    abstract::Marine organisms exhibit some advantages as a renewable source of potential drugs, far beyond chemotherapics. Particularly, the number of marine natural products with antithrombotic activity has increased in the last few years, and reports show a wide diversity in scaffolds, beyond the polysaccharide framework. While ...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Carvalhal F,Cristelo RR,Resende DISP,Pinto MMM,Sousa E,Correia-da-Silva M

    更新日期:2019-03-16 00:00:00

  • Aplysin sensitizes cancer cells to TRAIL by suppressing P38 MAPK/survivin pathway.

    abstract::TNF-related apoptosis-inducing ligand (TRAIL) is a tumor-selective apoptosis inducer and has been shown to be promising for treating various types of cancers. However, the application of TRAIL is greatly impeded by the resistance of cancer cells to its action. Studies show that overexpression of some critical pro-surv...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Liu J,Ma L,Wu N,Liu G,Zheng L,Lin X

    更新日期:2014-09-25 00:00:00

  • The Mediterranean red alga Asparagopsis: a source of compounds against Leishmania.

    abstract::Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae as a great source o...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Genovese G,Tedone L,Hamann MT,Morabito M

    更新日期:2009-08-11 00:00:00

  • Optimization of Collagenase Production by Pseudoalteromonas sp. SJN2 and Application of Collagenases in the Preparation of Antioxidative Hydrolysates.

    abstract::Collagenases are the most important group of commercially-produced enzymes. However, even though biological resources are abundant in the sea, very few of these commercially popular enzymes are from marine sources, especially from marine bacteria. We optimized the production of marine collagenases by Pseudoalteromonas...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yang X,Xiao X,Liu D,Wu R,Wu C,Zhang J,Huang J,Liao B,He H

    更新日期:2017-12-04 00:00:00

  • Drimane Sesquiterpene-Conjugated Amino Acids from a Marine Isolate of the Fungus Talaromyces minioluteus (Penicillium Minioluteum).

    abstract::Four new sesquiterpene lactones (3, 4, 6 and 7) and three known compounds, purpuride (1), berkedrimane B (2) and purpuride B (5), were isolated from the marine fungus, Talaromyces minioluteus (Penicillium minioluteum). New compounds were drimane sesquiterpenes conjugated with N-acetyl-l-valine, and their structures we...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ngokpol S,Suwakulsiri W,Sureram S,Lirdprapamongkol K,Aree T,Wiyakrutta S,Mahidol C,Ruchirawat S,Kittakoop P

    更新日期:2015-06-05 00:00:00

  • Discovery of Two New Sorbicillinoids by Overexpression of the Global Regulator LaeA in a Marine-Derived Fungus Penicillium dipodomyis YJ-11.

    abstract::Overexpression of the global regulator LaeA in a marine-derived fungal strain of Penicillium dipodomyis YJ-11 induced obvious morphological changes and metabolic variations. Further chemical investigation of the mutant strain afforded a series of sorbicillinoids including two new ones named 10,11-dihydrobislongiquinol...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yu J,Han H,Zhang X,Ma C,Sun C,Che Q,Gu Q,Zhu T,Zhang G,Li D

    更新日期:2019-07-28 00:00:00

  • Characterization and cytotoxicity studies of the rare 21:4 n-7 acid and other polyunsaturated fatty acids from the marine opisthobranch Scaphander lignarius, isolated using bioassay guided fractionation.

    abstract::The marine opisthobranch Scaphander lignarius has been analyzed in the systematic search for novel bioactive compounds in Arctic marine organisms using bioassay guided fractionation. A number of highly cytotoxic fractions were shown to contain mainly polyunsaturated fatty acids (PUFAs). Selected PUFAs were isolated an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Vasskog T,Andersen JH,Hansen E,Svenson J

    更新日期:2012-12-01 00:00:00

  • Combination of trabectedin and gemcitabine for advanced soft tissue sarcomas: results of a phase I dose escalating trial of the German Interdisciplinary Sarcoma Group (GISG).

    abstract:BACKGROUND:Evaluation of the potential efficacy and safety of combination therapies for advanced soft tissue sarcomas (STS) has increased substantially after approval of trabectedin and pazopanib. Trabectedin's introduction in Europe in 2007 depended mainly on its activity in so-called L-sarcomas (liposarcoma and leiom...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kasper B,Reichardt P,Pink D,Sommer M,Mathew M,Rauch G,Hohenberger P

    更新日期:2015-01-13 00:00:00

  • Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013.

    abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sheu JH,Chen YH,Chen YH,Su YD,Chang YC,Su JH,Weng CF,Lee CH,Fang LS,Wang WH,Wen ZH,Wu YC,Sung PJ

    更新日期:2014-04-10 00:00:00

  • Isoaaptamine Induces T-47D Cells Apoptosis and Autophagy via Oxidative Stress.

    abstract::Aaptos is a genus of marine sponge which belongs to Suberitidae and is distributed in tropical and subtropical oceans. Bioactivity-guided fractionation of Aaptos sp. methanolic extract resulted in the isolation of aaptamine, demethyloxyaaptamine, and isoaaptamine. The cytotoxic activity of the isolated compounds was e...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wu CF,Lee MG,El-Shazly M,Lai KH,Ke SC,Su CW,Shih SP,Sung PJ,Hong MC,Wen ZH,Lu MC

    更新日期:2018-01-09 00:00:00

  • Pharmacokinetics of Jaspine B and Enhancement of Intestinal Absorption of Jaspine B in the Presence of Bile Acid in Rats.

    abstract::We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Choi MK,Lee J,Nam SJ,Kang YJ,Han Y,Choi K,Choi YA,Kwon M,Lee D,Song IS

    更新日期:2017-09-01 00:00:00

  • Plakofuranolactone as a Quorum Quenching Agent from the Indonesian Sponge Plakortis cf. lita.

    abstract::There is an urgent need for novel strategies to fight drug resistance and multi-drug resistance. As an alternative to the classic antibiotic therapy, attenuation of the bacteria virulence affecting their Quorum sensing (QS) system is a promising approach. Quorum sensing (QS) is a genetic regulation system that allows ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Costantino V,Della Sala G,Saurav K,Teta R,Bar-Shalom R,Mangoni A,Steindler L

    更新日期:2017-02-28 00:00:00

  • The Positive Role of Curcumin-Loaded Salmon Nanoliposomes on the Culture of Primary Cortical Neurons.

    abstract::Curcumin (diferuloylmethane) is a natural bioactive compound with many health-promoting benefits. However, its poor water solubility and bioavailability has limited curcumin’s biomedical application. In the present study, we encapsulated curcumin into liposomes, formed from natural sources (salmon lecithin), and...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Hasan M,Latifi S,Kahn CJF,Tamayol A,Habibey R,Passeri E,Linder M,Arab-Tehrany E

    更新日期:2018-06-25 00:00:00

  • Chitosan-Based Nanomedicine to Fight Genital Candida Infections: Chitosomes.

    abstract::Vaginal infections are associated with high recurrence, which is often due to a lack of efficient treatment of complex vaginal infections comprised of several types of pathogens, especially fungi and bacteria. Chitosan, a mucoadhesive polymer with known antifungal effect, could offer a great improvement in vaginal the...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Andersen T,Mishchenko E,Flaten GE,Sollid JU,Mattsson S,Tho I,Škalko-Basnet N

    更新日期:2017-03-04 00:00:00

  • Antiviral activities of sulfated polysaccharides isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales).

    abstract::Water-soluble sulfated polysaccharides isolated from two red algae Sphaerococcus coronopifolius (Gigartinales, Sphaerococcaceae) and Boergeseniella thuyoides (Ceramiales, Rhodomelaceae) collected on the coast of Morocco inhibited in vitro replication of the Human Immunodeficiency Virus (HIV) at 12.5 μg/mL. In addition...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Bouhlal R,Haslin C,Chermann JC,Colliec-Jouault S,Sinquin C,Simon G,Cerantola S,Riadi H,Bourgougnon N

    更新日期:2011-01-01 00:00:00

  • Spirulina maxima Derived Pectin Nanoparticles Enhance the Immunomodulation, Stress Tolerance, and Wound Healing in Zebrafish.

    abstract::In this study, Spirulina maxima derived pectin nanoparticles (SmPNPs) were synthesized and multiple biological effects were investigated using in vitro and in vivo models. SmPNPs were not toxic to Raw 264.7 cells and zebrafish embryos up to 1 mg/mL and 200 µg/mL, respectively. SmPNPs upregulated Il 10, Cat, Sod 2, Def...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Rajapaksha DC,Edirisinghe SL,Nikapitiya C,Dananjaya S,Kwun HJ,Kim CH,Oh C,Kang DH,De Zoysa M

    更新日期:2020-11-07 00:00:00

  • Astaxanthin attenuates the apoptosis of retinal ganglion cells in db/db mice by inhibition of oxidative stress.

    abstract::Diabetic retinopathy is a common diabetic eye disease caused by changes in retinal ganglion cells (RGCs). It is an ocular manifestation of systemic disease, which affects up to 80% of all patients who have had diabetes for 10 years or more. The genetically diabetic db/db mouse, as a model of type-2 diabetes, shows dia...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Dong LY,Jin J,Lu G,Kang XL

    更新日期:2013-03-21 00:00:00

  • New α-Glucosidase Inhibitory Triterpenic Acid from Marine Macro Green Alga Codium dwarkense Boergs.

    abstract::The marine ecosystem has been a key resource for secondary metabolites with promising biological roles. In the current study, bioassay-guided phytochemical investigations were carried out to assess the presence of enzyme inhibitory chemical constituents from the methanolic extract of marine green alga-Codium dwarkense...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Ali L,Khan AL,Al-Kharusi L,Hussain J,Al-Harrasi A

    更新日期:2015-07-14 00:00:00

  • Domoic acid epileptic disease.

    abstract::Domoic acid epileptic disease is characterized by spontaneous recurrent seizures weeks to months after domoic acid exposure. The potential for this disease was first recognized in a human case study of temporal lobe epilepsy after the 1987 amnesic shellfish-poisoning event in Quebec, and was characterized as a chronic...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Ramsdell JS,Gulland FM

    更新日期:2014-03-06 00:00:00

  • Bacterial Long-Chain Polyunsaturated Fatty Acids: Their Biosynthetic Genes, Functions, and Practical Use.

    abstract::The nutritional and pharmaceutical values of long-chain polyunsaturated fatty acids (LC-PUFAs) such as arachidonic, eicosapentaenoic and docosahexaenoic acids have been well recognized. These LC-PUFAs are physiologically important compounds in bacteria and eukaryotes. Although little is known about the biosynthetic me...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Yoshida K,Hashimoto M,Hori R,Adachi T,Okuyama H,Orikasa Y,Nagamine T,Shimizu S,Ueno A,Morita N

    更新日期:2016-05-12 00:00:00

  • Virescenosides From the Holothurian-Associated Fungus Acremonium Striatisporum Kmm 4401.

    abstract::Ten new diterpene glycosides virescenosides Z9-Z18 (1-10) together with three known analogues (11-13) and aglycon of virescenoside A (14) were isolated from the marine-derived fungus Acremonium striatisporum KMM 4401. These compounds were obtained by cultivating fungus on wort agar medium with the addition of potassiu...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Zhuravleva OI,Antonov AS,Oleinikova GK,Khudyakova YV,Popov RS,Denisenko VA,Pislyagin EA,Chingizova EA,Afiyatullov SS

    更新日期:2019-10-29 00:00:00

  • Fucoxanthin: a marine carotenoid exerting anti-cancer effects by affecting multiple mechanisms.

    abstract::Fucoxanthin is a marine carotenoid exhibiting several health benefits. The anti-cancer effect of fucoxanthin and its deacetylated metabolite, fucoxanthinol, is well documented. In view of its potent anti-carcinogenic activity, the need to understand the underlying mechanisms has gained prominence. Towards achieving th...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Kumar SR,Hosokawa M,Miyashita K

    更新日期:2013-12-16 00:00:00