Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

Abstract:

:In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.

journal_name

Mar Drugs

journal_title

Marine drugs

authors

Wu DL,Li HJ,Smith DR,Jaratsittisin J,Xia-Ke-Er XF,Ma WZ,Guo YW,Dong J,Shen J,Yang DP,Lan WJ

doi

10.3390/md16070229

subject

Has Abstract

pub_date

2018-07-06 00:00:00

issue

7

issn

1660-3397

pii

md16070229

journal_volume

16

pub_type

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