Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

abstract：:Six regioisomers associated with the tricyclic core of thiaplakortones A-D have been synthesized. Reaction of 1H-indole-4,7-dione and 1-tosyl-1H-indole-4,7-dione with 2-aminoethanesulfinic acid afforded a regioisomeric series, which was subsequently deprotected and oxidized to yield the tricyclic core scaffolds presen...

journal_title：Marine drugs

authors： Schwartz BD,Coster MJ,Skinner-Adams TS,Andrews KT,White JM,Davis RA

更新日期：2015-09-15 00:00:00

abstract：:In recent years many sterols with unusual structures and promising biological profiles have been identified from marine sources. Here we report the isolation of a series of 24-alkylated-hydroxysteroids from the soft coral Sinularia kavarattiensis, acting as pregnane X receptor (PXR) modulators. Starting from this scaf...

journal_title：Marine drugs

authors： Sepe V,Di Leva FS,D'Amore C,Festa C,De Marino S,Renga B,D'Auria MV,Novellino E,Limongelli V,D'Souza L,Majik M,Zampella A,Fiorucci S

更新日期：2014-05-27 00:00:00

abstract：:Two new cyclotetrapeptides, sartoryglabramides A (5) and B (6), and a new analog of fellutanine A (8) were isolated, together with six known compounds including ergosta-4, 6, 8 (14), 22-tetraen-3-one, ergosterol 5, 8-endoperoxide, helvolic acid, aszonalenin (1), (3R)-3-(1H-indol-3-ylmethyl)-3,4-dihydro-1H-1,4-benzodia...

journal_title：Marine drugs

authors： May Zin WW,Buttachon S,Dethoup T,Fernandes C,Cravo S,Pinto MM,Gales L,Pereira JA,Silva AM,Sekeroglu N,Kijjoa A

更新日期：2016-07-20 00:00:00

abstract：:A new eunicellin diterpenoid, cladieunicellin I (1), and a new natural eunicellin, litophynin I diacetate (2), were isolated from a Formosan soft coral identified as Cladiella sp. The structures of eunicellins 1 and 2 were elucidated by spectroscopic methods and by comparison of the spectral data with those of related...

journal_title：Marine drugs

authors： Chen TH,Lu MC,Chang YC,Su YD,Chen YH,Lin NC,Fang LS,Wu YC,Sung PJ

更新日期：2013-11-14 00:00:00

abstract：:The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...

journal_title：Marine drugs

authors： Tsai TC,Lai KH,Su JH,Wu YJ,Sheu JH

更新日期：2018-03-26 00:00:00

abstract：:In this study, Spirulina maxima derived pectin nanoparticles (SmPNPs) were synthesized and multiple biological effects were investigated using in vitro and in vivo models. SmPNPs were not toxic to Raw 264.7 cells and zebrafish embryos up to 1 mg/mL and 200 µg/mL, respectively. SmPNPs upregulated Il 10, Cat, Sod 2, Def...

journal_title：Marine drugs

authors： Rajapaksha DC,Edirisinghe SL,Nikapitiya C,Dananjaya S,Kwun HJ,Kim CH,Oh C,Kang DH,De Zoysa M

更新日期：2020-11-07 00:00:00

abstract：:Pseudopterosins and pseudopteroxazole are intriguing marine natural products that possess notable antimicrobial activity with a commensurate lack of cytotoxicity. New semi-synthetic pseudopteroxazoles, pseudopteroquinoxalines and pseudopterosin congeners along with simple synthetic mimics of the terpene skeleton were ...

journal_title：Marine drugs

authors： McCulloch MW,Haltli B,Marchbank DH,Kerr RG

更新日期：2012-08-01 00:00:00

abstract：:A new alkaloid, 2-(furan-2-yl)-6-(2S,3S,4-trihydroxybutyl)pyrazine (1), along with 12 known compounds, 2-(furan-2-yl)-5-(2S,3S,4-trihydroxybutyl)pyrazine (2), (S)-4-isobutyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyde (3), (S)-4-isopropyl-3-oxo-3,4-dihydro-1H-pyrrolo[2,1-c][1,4]oxazine-6-carbaldehyd...

journal_title：Marine drugs

authors： Wang P,Kong F,Wei J,Wang Y,Wang W,Hong K,Zhu W

更新日期：2014-01-21 00:00:00

abstract：:Chinese white dolphin (Sousa chinensis), also known as the Indo-Pacific humpback dolphin, has been classified as "Vulnerable" on the IUCN Red List of Threatened Species. It is a special cetacean species that lives in tropical and subtropical nearshore waters, with significant differences from other cetaceans. Here, we...

journal_title：Marine drugs

authors： Jia K,Bian C,Yi Y,Li Y,Jia P,Gui D,Zhang X,Lin W,Sun X,Lv Y,Li J,You X,Shi Q,Yi M,Wu Y

更新日期：2019-08-28 00:00:00

abstract：:The total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lau...

journal_title：Marine drugs

authors： Giltrap AM,Cergol KM,Pang A,Britton WJ,Payne RJ

更新日期：2013-07-08 00:00:00

abstract：:Lipid A is a fundamental Gram-negative outer membrane component and the essential element of lipopolysaccharide (endotoxin), a potent immunostimulatory molecule. This work describes the metabolic adaptation of the lipid A acyl structure by Psychrobacter cryohalolentis at various temperatures in its facultative psychro...

journal_title：Marine drugs

authors： Sweet CR,Watson RE,Landis CA,Smith JP

更新日期：2015-07-30 00:00:00

abstract：:Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...

journal_title：Marine drugs

authors： Koopmans M,Martens D,Wijffels RH

更新日期：2009-12-02 00:00:00

abstract：:In recent years, noteworthy research has been performed around lipids from microalgae. Among lipids, glycolipids (GLs) are quite abundant in microalgae and are considered an important source of fatty acids (FAs). GLs are rich in 16- and 18-carbon saturated and unsaturated fatty acids and often contain polyunsaturated ...

journal_title：Marine drugs

authors： da Costa E,Silva J,Mendonça SH,Abreu MH,Domingues MR

更新日期：2016-05-19 00:00:00

abstract：:A chemical study of the ethyl acetate (EtOAc) extract from the deep-sea-derived fungus Penicilliumthomii YPGA3 led to the isolation of a new austalide meroterpenoid (1) and seven known analogues (28), two new labdane-type diterpenoids (9 and 10) and a known derivative (11). The structures of new compounds 1, 9, and 10...

journal_title：Marine drugs

authors： Cheng Z,Liu W,Fan R,Han S,Li Y,Cui X,Zhang J,Wu Y,Lv X,Zhang Y,Luo Z,Alias SA,Xu W,Li Q

更新日期：2020-03-16 00:00:00

abstract：:We aimed to investigate the pharmacokinetics and the underlying mechanisms of the intestinal absorption, distribution, metabolism, and excretion of Jaspine B in rats. The oral bioavailability of Jaspine B was 6.2%, but it decreased to 1.6% in bile-depleted rats and increased to 41.2% (normal) and 23.5% (bile-depleted)...

journal_title：Marine drugs

authors： Choi MK,Lee J,Nam SJ,Kang YJ,Han Y,Choi K,Choi YA,Kwon M,Lee D,Song IS

更新日期：2017-09-01 00:00:00

abstract：:Carotenoids are lipid-soluble pigments that are produced in some plants, algae, fungi, and bacterial species, which accounts for their orange and yellow hues. Carotenoids are powerful antioxidants thanks to their ability to quench singlet oxygen, to be oxidized, to be isomerized, and to scavenge free radicals, which p...

journal_title：Marine drugs

authors： Gammone MA,Riccioni G,D'Orazio N

更新日期：2015-09-30 00:00:00

abstract：:Although oncolytic viruses provide attractive vehicles for cancer treatment, their adverse effects are largely ignored. In this work, rat C6 glioblastoma cells were subcutaneously xenografted into mice, and a thymidine kinase-deficient oncolytic vaccinia virus (oncoVV) induced severe toxicity in this model. However, o...

journal_title：Marine drugs

authors： Li G,Mei S,Cheng J,Wu T,Luo J

更新日期：2018-04-26 00:00:00

abstract：:Terrosamycins A (1) and B (2), two polycyclic polyether natural products, were purified from the fermentation broth of Streptomyces sp. RKND004 isolated from Prince Edward Island sediment. The one strain-many compounds (OSMAC) approach coupled with UPLC-HRMS-based metabolomics screening led to the identification of th...

journal_title：Marine drugs

authors： Sproule A,Correa H,Decken A,Haltli B,Berrué F,Overy DP,Kerr RG

更新日期：2019-06-11 00:00:00

abstract：:Domoic acid produced by marine algae has been shown to cause acute and chronic neurologic sequelae in Californian sea lions following acute or low-dose exposure. Histological findings in affected animals included a degenerative cardiomyopathy that was hypothesized to be caused by over-excitation of the glutamate recep...

journal_title：Marine drugs

authors： Gill S,Goldstein T,Situ D,Zabka TS,Gulland FM,Mueller RW

更新日期：2010-05-06 00:00:00

abstract：:In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...

journal_title：Marine drugs

authors： Park MK,Jung U,Roh C

更新日期：2011-01-01 00:00:00

abstract：:MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc). MytiLec revealed β-trefoil folding as also found in the ricin B-subunit type (R-type) lectin family, although the amino acid sequences were quite different....

journal_title：Marine drugs

authors： Hasan I,Sugawara S,Fujii Y,Koide Y,Terada D,Iimura N,Fujiwara T,Takahashi KG,Kojima N,Rajia S,Kawsar SM,Kanaly RA,Uchiyama H,Hosono M,Ogawa Y,Fujita H,Hamako J,Matsui T,Ozeki Y

更新日期：2015-12-14 00:00:00

abstract：:We test previous claims that the bacteria Vibrio alginolyticus produces tetrodotoxin (TTX) when living in symbiosis with the nemertean Lineus longissimus by a setup with bacteria cultivation for TTX production. Toxicity experiments on the shore crab, Carcinus maenas, demonstrated the presence of a paralytic toxin, but...

journal_title：Marine drugs

authors： Strand M,Hedström M,Seth H,McEvoy EG,Jacobsson E,Göransson U,Andersson HS,Sundberg P

更新日期：2016-03-25 00:00:00

abstract：:Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...

journal_title：Marine drugs

authors： Niu S,Yang L,Chen T,Hong B,Pei S,Shao Z,Zhang G

更新日期：2020-11-17 00:00:00

abstract：:Marine ecosystems are the most prevalent ecosystems on the planet, providing a diversity of living organisms and resources. The development of nanotechnology may provide solutions for utilizing these thousands of potential compounds as marine pharmaceuticals. Here, we designed a liposomal glycol chitosan formulation t...

journal_title：Marine drugs

authors： Kim MW,Niidome T,Lee R

更新日期：2019-10-12 00:00:00

abstract：:A bioactivity guided study of a cf. Caldora penicillata species, collected during a 2013 expedition to the Pacific island of Saipan, Northern Mariana Islands (a commonwealth of the USA), led to the isolation of a new thiazoline-containing alkaloid, laucysteinamide A (1). Laucysteinamide A is a new monomeric analogue o...

journal_title：Marine drugs

authors： Zhang C,Naman CB,Engene N,Gerwick WH

更新日期：2017-04-14 00:00:00

abstract：:One new α-pyrone (nocapyrone R (1)), and three known γ-pyrones (nocapyrones B, H and L (2-4)) were isolated from the culture extract of a Nocardiopsis strain collected from marine sediment. Structures of these compounds were determined on the basis of spectroscopic data including NMR and MS. γ-Pyrones 2-4 were found t...

journal_title：Marine drugs

authors： Kim Y,Ogura H,Akasaka K,Oikawa T,Matsuura N,Imada C,Yasuda H,Igarashi Y

更新日期：2014-07-08 00:00:00

abstract：:Ten new triterpenoid compounds with structure diversity of the C-17 side-chain, including nine tirucallanes, named xylocarpols A⁻E (1⁻5) and agallochols A⁻D (6⁻9), and an apotirucallane, named 25-dehydroxy protoxylogranatin B (10), were isolated from the mangrove plants Xylocarpus granatum, Xylocarpus moluccensis, and...

journal_title：Marine drugs

authors： Jiang ZP,Luan ZL,Liu RX,Zhang Q,Ma XC,Shen L,Wu J

更新日期：2018-12-06 00:00:00

abstract：:Most giant groupers in the market are derived from inbred stock. Inbreeding can cause trait depression, compromising the animals' fitness and disease resistance, obligating farmers to apply increased amounts of drugs. In order to solve this problem, a pedigree classification method is needed. Here, microsatellite and ...

journal_title：Marine drugs

authors： Kuo HC,Hsu HH,Chua CS,Wang TY,Chen YM,Chen TY

更新日期：2014-04-30 00:00:00

abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

journal_title：Marine drugs

authors： Zhang W,Sun T,Ma Z,Li Y

更新日期：2014-04-22 00:00:00

abstract：:Two new steroids, crellasterones A (1) and B (2), together with the previously reported compound chalinasterol (3) and several nucleosides (4-7), were isolated from the sponge Crella incrustans, collected in New Caledonia. The structures of the new compounds were established by extensive NMR and mass spectroscopic ana...

journal_title：Marine drugs

authors： Ragini K,Piggott AM,Karuso P

更新日期：2017-06-15 00:00:00