Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.

abstract：:MytiLec; a novel lectin isolated from the Mediterranean mussel (Mytilus galloprovincialis); shows strong binding affinity to globotriose (Gb3: Galα1-4Galβ1-4Glc). MytiLec revealed β-trefoil folding as also found in the ricin B-subunit type (R-type) lectin family, although the amino acid sequences were quite different....

journal_title：Marine drugs

authors： Hasan I,Sugawara S,Fujii Y,Koide Y,Terada D,Iimura N,Fujiwara T,Takahashi KG,Kojima N,Rajia S,Kawsar SM,Kanaly RA,Uchiyama H,Hosono M,Ogawa Y,Fujita H,Hamako J,Matsui T,Ozeki Y

更新日期：2015-12-14 00:00:00

abstract：:In this study, we developed novel chitosan/fucoidan nanoparticles (CS/F NPs) using a simple polyelectrolyte self-assembly method and evaluated their potential to be antioxidant carriers. As the CS/F weight ratio was 5/1, the CS/F NPs were spherical and exhibited diameters of approximately 230-250 nm, as demonstrated b...

journal_title：Marine drugs

authors： Huang YC,Li RY

更新日期：2014-07-31 00:00:00

abstract：:Proteins from different fish species and different raw materials such as fish fillets and by-products have shown promising cardioprotective effects in rodents and humans, including effects on cholesterol metabolism. Blue whiting is used mainly to produce fish meal for the feed industry and during this production, a wa...

journal_title：Marine drugs

authors： Drotningsvik A,Vikøren LA,Mjøs SA,Oterhals Å,Pampanin D,Flesland O,Gudbrandsen OA

更新日期：2018-05-01 00:00:00

abstract：:This study aimed to investigate the cardiovascular effects elicited by Dictyota pulchella, a brown alga, using in vivo and in vitro approaches. In normotensive conscious rats, CH(2)Cl(2)/MeOH Extract (CME, 5, 10, 20 and 40 mg/kg) from Dictyota pulchella produced dose-dependent hypotension (-4 ± 1; -8 ± 2; -53 ± 8 and ...

journal_title：Marine drugs

authors： Queiroz TM,Machado NT,Furtado FF,Oliveira-Filho AA,Alustau MC,Figueiredo CS,Miranda GE,Barbosa-Filho JM,Braga VA,Medeiros IA

更新日期：2011-01-01 00:00:00

abstract：:Two strains of Azadinium poporum, one from the Korean West coast and the other from the North Sea, were mass cultured for isolation of new azaspiracids. Approximately 0.9 mg of pure AZA-36 (1) and 1.3 mg of pure AZA-37 (2) were isolated from the Korean (870 L) and North Sea (120 L) strains, respectively. The structure...

journal_title：Marine drugs

authors： Krock B,Tillmann U,Potvin É,Jeong HJ,Drebing W,Kilcoyne J,Al-Jorani A,Twiner MJ,Göthel Q,Köck M

更新日期：2015-10-30 00:00:00

abstract：:The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxyge...

journal_title：Marine drugs

authors： Ermolenko EV,Imbs AB,Gloriozova TA,Poroikov VV,Sikorskaya TV,Dembitsky VM

更新日期：2020-12-02 00:00:00

abstract：:Seaweeds have attracted high interest in recent years due to their chemical and bioactive properties to find new molecules with valuable applications for humankind. Phenolic compounds are the group of metabolites with the most structural variation and the highest content in seaweeds. The most researched seaweed polyph...

journal_title：Marine drugs

authors： Cotas J,Leandro A,Monteiro P,Pacheco D,Figueirinha A,Gonçalves AMM,da Silva GJ,Pereira L

更新日期：2020-07-24 00:00:00

abstract：:The 7-Acetylsinumaximol B (7-AB), a bioactive cembranoid, was originally discovered from aquaculture soft coral Sinularia sandensis. The current study investigated the anti-proliferative property of 7-AB towards the NCI-N87 human gastric cancer cell line. An MTT cell proliferative assay was applied to evaluate cell su...

journal_title：Marine drugs

authors： Tsai TC,Lai KH,Su JH,Wu YJ,Sheu JH

更新日期：2018-03-26 00:00:00

abstract：:Microalgae oil is an optimal feedstock for nutraceutical, pharmaceutical and biodiesel production, but its high levels of chlorophyll limit its large-scale application. To date, few effective approaches have been developed to remove chlorophyll from microalgae oil. The main purpose of this study was to present a prepr...

journal_title：Marine drugs

authors： Li T,Xu J,Wu H,Wang G,Dai S,Fan J,He H,Xiang W

更新日期：2016-09-07 00:00:00

abstract：:Three new polyoxygenated steroids, michosterols A-C (1-3), and four known compounds (4-7) were isolated from the ethyl acetate (EtOAc) extract of the soft coral Lobophytum michaelae, collected off the coast of Taitung. The structures of the new compounds were elucidated on the basis of spectroscopic analyses and compa...

journal_title：Marine drugs

authors： Huang CY,Tseng WR,Ahmed AF,Chiang PL,Tai CJ,Hwang TL,Dai CF,Sheu JH

更新日期：2018-03-13 00:00:00

abstract：:Separacenes A-D (1-4), novel polyene polyols, were isolated from Streptomyces sp. collected from the southern area of Jeju Island, Korea. The chemical structures of 1-4 were established by NMR, mass, UV, and IR spectroscopy as well as the modified Mosher's method. Separacenes A-B (1-2), which share an identical planar...

journal_title：Marine drugs

authors： Bae M,Kim H,Shin Y,Kim BY,Lee SK,Oh KB,Shin J,Oh DC

更新日期：2013-08-13 00:00:00

abstract：:The total syntheses of the marine-derived lipopeptide natural product fellutamide B and deoxy-fellutamides B, C, and D are reported. These compounds were accessed through a novel solid-phase synthetic strategy using Weinreb amide-derived resin. As part of the synthesis, a new enantioselective route to (3R)-hydroxy lau...

journal_title：Marine drugs

authors： Giltrap AM,Cergol KM,Pang A,Britton WJ,Payne RJ

更新日期：2013-07-08 00:00:00

abstract：:Marine natural products (MNPs) continue to be in the spotlight in the global drug discovery endeavor. Currently, more than 30,000 structurally diverse secondary metabolites from marine sources have been isolated, making MNPs a profound, renewable source to investigate novel drug compounds. Marine sponges of the genus ...

journal_title：Marine drugs

authors： El-Demerdash A,Atanasov AG,Horbanczuk OK,Tammam MA,Abdel-Mogib M,Hooper JNA,Sekeroglu N,Al-Mourabit A,Kijjoa A

更新日期：2019-02-12 00:00:00

abstract：:Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether (BDDE) is a bromophenol isolated from marine algae. Previous reports have shown that BDDE possesses cytotoxic and antibacterial activity. In the present study, we demonstrate that BDDE displays broad-spectrum antifungal activities, especially on Botrytis cinerea. BDDE inhibit...

journal_title：Marine drugs

authors： Liu M,Wang G,Xiao L,Xu X,Liu X,Xu P,Lin X

更新日期：2014-06-27 00:00:00

abstract：:Chemical analysis of the Indonesian sponge Plakortis cfr. lita afforded two new analogues of the potent trypanocidal agent manadoperoxide B (1), namely 12-isomanadoperoxide B (2) and manadoperoxidic acid B (3). These compounds were isolated along with a new short chain dicarboxylate monoester (4), bearing some interes...

journal_title：Marine drugs

authors： Chianese G,Scala F,Calcinai B,Cerrano C,Dien HA,Kaiser M,Tasdemir D,Taglialatela-Scafati O

更新日期：2013-08-28 00:00:00

abstract：:Four new compounds (1-4), including two brevianamides and two mycochromenic acid derivatives along with six known compounds were isolated from the deep-sea-derived fungus Penicillium brevicompactum DFFSCS025. Their structures were elucidated by spectroscopic analysis. Moreover, the absolute configurations of 1 and 2 w...

journal_title：Marine drugs

authors： Xu X,Zhang X,Nong X,Wang J,Qi S

更新日期：2017-02-17 00:00:00

abstract：:To date, studies describing myxobacterial secondary metabolites have been relatively scarce in comparison to those addressing actinobacterial secondary metabolites. This realization suggests the immense potential of myxobacteria as an intriguing source of secondary metabolites with unusual structural features and a wi...

journal_title：Marine drugs

authors： Zhang F,Braun DR,Rajski SR,DeMaria D,Bugni TS

更新日期：2019-12-12 00:00:00

abstract：:Climate change with increasing temperature and ocean acidification (OA) poses risks for marine ecosystems. According to Pörtner and Farrell, synergistic effects of elevated temperature and CO₂-induced OA on energy metabolism will narrow the thermal tolerance window of marine ectothermal animals. To test this hypothesi...

journal_title：Marine drugs

authors： Lannig G,Eilers S,Pörtner HO,Sokolova IM,Bock C

更新日期：2010-08-11 00:00:00

abstract：:Eighteen analogues of the marine cytotoxic linear peptide tasiamide were designed, synthesized and screened for their inhibitory activities against the growth of human nasopharyngeal carcinoma (KB) and human non-small cell lung tumor (A549) cell lines. The results indicated that minor modifications of the C-terminus w...

journal_title：Marine drugs

authors： Zhang W,Sun T,Ma Z,Li Y

更新日期：2014-04-22 00:00:00

abstract：:Four new xanthene derivatives, penicixanthenes A-D (1-4), and one known compound 5 were isolated from a marine mangrove endophytic fungus Penicillium sp. JY246 that was obtained from the stem of Ceriops tagal. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher's method, and calcul...

journal_title：Marine drugs

authors： Bai M,Zheng CJ,Nong XH,Zhou XM,Luo YP,Chen GY

更新日期：2019-11-20 00:00:00

abstract：:Padina sanctae-crucis Børgesen is distributed worldwide in tropical and subtropical seas; belongs to the Dictyotaceae family, and has proven to be an exceptional source of biologically active compounds. Four compounds were isolated and identified, namely: dolastane diterpene new for the genus Padina; phaeophytin and h...

journal_title：Marine drugs

authors： Nogueira RBSS,Tomaz ACA,Pessoa DR,Xavier AL,Pita JCLR,Sobral MV,Pontes MLC,Pessôa HLF,Diniz MFFM,Miranda GEC,Vieira MAR,Marques MOM,Souza MFV,Cunha EVL

更新日期：2017-09-26 00:00:00

abstract：:Here we summarize the current knowledge on the transfer and accumulation of harmful algal bloom (HAB)-related toxins in cephalopods (octopods, cuttlefishes and squids). These mollusks have been reported to accumulate several HAB-toxins, namely domoic acid (DA, and its isomers), saxitoxin (and its derivatives) and paly...

journal_title：Marine drugs

authors： Lopes VM,Lopes AR,Costa P,Rosa R

更新日期：2013-09-06 00:00:00

abstract：:In the chemical investigation of marine unicellular bacteria, a new peptide, thalassospiramide G (1), along with thalassospiramides A and D (2-3), was discovered from a large culture of Thalassospira sp. The structure of thalassospiramide G, bearing γ-amino acids, such as 4-amino-5-hydroxy-penta-2-enoic acid (AHPEA),...

journal_title：Marine drugs

authors： Um S,Pyee Y,Kim EH,Lee SK,Shin J,Oh DC

更新日期：2013-02-26 00:00:00

abstract：:Chemical interactions play a fundamental role in the ecology of marine foodwebs. Dimethyl sulfide (DMS) is a ubiquitous marine trace gas that acts as a bioactive compound by eliciting foraging behavior in a range of marine taxa including the copepod Temora longicornis. Production of DMS can rapidly increase following ...

journal_title：Marine drugs

authors： Breckels MN,Bode NW,Codling EA,Steinke M

更新日期：2013-07-15 00:00:00

abstract：:Nemerteans (ribbon worms) employ toxins to subdue their prey, but research thus far has focused on the small-molecule components of mucus secretions and few protein toxins have been characterized. We carried out a preliminary proteotranscriptomic analysis of putative toxins produced by the hoplonemertean Amphiporus la...

journal_title：Marine drugs

authors： von Reumont BM,Lüddecke T,Timm T,Lochnit G,Vilcinskas A,von Döhren J,Nilsson MA

更新日期：2020-08-01 00:00:00

abstract：:Species in the genus Gambierdiscus produce ciguatoxins (CTXs) and/or maitotoxins (MTXs), which may cause ciguatera fish poisoning (CFP) in humans if contaminated fish are consumed. Species of Gambierdiscus have previously been isolated from macroalgae at Rangitahua (Raoul Island and North Meyer Islands, northern Kerma...

journal_title：Marine drugs

authors： Rhodes LL,Smith KF,Murray S,Harwood DT,Trnski T,Munday R

更新日期：2017-07-11 00:00:00

abstract：:Oxidative stress is the main cause of diabetic nephropathy (DN) progression. Nuclear factor-erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) signaling is a crucial cellular defense system to cope with oxidative stress. Astaxanthin (AST) is a fat-soluble xanthophyll carotenoid with remarkable anti...

journal_title：Marine drugs

authors： Xie X,Chen Q,Tao J

更新日期：2018-04-05 00:00:00

abstract：:Resistance to chemotherapy occurs in various diseases (i.e., cancer and infection), and for this reason, both are very difficult to treat. Therefore, novel antimicrobial and chemotherapic drugs are needed for effective antibiotic therapy. The aim of the present study was to assess the antimicrobial and anti-proliferat...

journal_title：Marine drugs

authors： Fuochi V,Li Volti G,Camiolo G,Tiralongo F,Giallongo C,Distefano A,Petronio Petronio G,Barbagallo I,Viola M,Furneri PM,Di Rosa M,Avola R,Tibullo D

更新日期：2017-11-01 00:00:00

abstract：:Carotenoids are lipophilic pigments found in plants and algae, as well as some bacteria, archaea, and fungi that serve two functions-(1) as light harvesting molecules-primary carotenoids, and (2) as antioxidants, acting against reactive oxygen species⁻secondary carotenoids. Because of their strong antioxidant properti...

journal_title：Marine drugs

authors： Laje K,Seger M,Dungan B,Cooke P,Polle J,Holguin FO

更新日期：2019-03-22 00:00:00

abstract：:In this study, we elucidated the inhibitory effect of fucoidan from marine brown algae on the lipid accumulation in differentiated 3T3-L1 adipocytes and its mechanism. The treatment of fucoidan in a dose-dependent manner was examined on lipid inhibition in 3T3-L1 cells by using Oil Red O staining. Fucoidan showed high...

journal_title：Marine drugs

authors： Park MK,Jung U,Roh C

更新日期：2011-01-01 00:00:00