Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus.


:In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.


Mar Drugs


Marine drugs


Wu DL,Li HJ,Smith DR,Jaratsittisin J,Xia-Ke-Er XF,Ma WZ,Guo YW,Dong J,Shen J,Yang DP,Lan WJ




Has Abstract


2018-07-06 00:00:00










  • Pharmacokinetic Study of Bioactive Glycopeptide from Strongylocentrotus droebachiensis After Intranasal Administration to Rats Using Biomarker Approach.

    abstract::A glycopeptide fraction (GPF) from internal organs of green sea urchins (Strongylocentrotus droebachiensis Müller, Strongylocentrotidae) has been reported to be an effective bronchitis treatment. In this study, we evaluated the pharmacokinetic and tissue distribution of GPF, following single and repeated intranasal (i...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Shikov AN,Pozharitskaya ON,Faustova NM,Kosman VM,Makarov VG,Razzazi-Fazeli E,Novak J

    更新日期:2019-10-11 00:00:00

  • Soft coral-derived lemnalol alleviates monosodium urate-induced gouty arthritis in rats by inhibiting leukocyte infiltration and iNOS, COX-2 and c-Fos protein expression.

    abstract::An acute gout attack manifests in the joint as dramatic inflammation. To date, the clinical use of medicinal agents has typically led to undesirable side effects. Numerous efforts have failed to create an effective and safe agent for the treatment of gout. Lemnalol-an extract from Formosan soft coral-has documented an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee HP,Huang SY,Lin YY,Wang HM,Jean YH,Wu SF,Duh CY,Wen ZH

    更新日期:2013-01-10 00:00:00

  • Nutritional Profiling and the Value of Processing By-Products from Gilthead Sea Bream (Sparus aurata).

    abstract::Fish processing industries generate a large volume of discards. In order to fulfil with the principles of a sustainable circular economy, it is necessary to maintain aquaculture by-products in the food chain through the production of high-value biomolecules that can be used as novel ingredients. In this study, we try ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Pateiro M,Munekata PES,Domínguez R,Wang M,Barba FJ,Bermúdez R,Lorenzo JM

    更新日期:2020-02-04 00:00:00

  • Antihypertensive and Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Fish as Potential Cardioprotective Compounds.

    abstract::The term metabolic/cardiometabolic/insulin resistance syndrome could generally be defined as the co-occurrence of several risk factors inclusive of systemic arterial hypertension. Not only that organizations, such as the world health organization (WHO) have identified high blood pressure as one of the main risk factor...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Abachi S,Bazinet L,Beaulieu L

    更新日期:2019-10-29 00:00:00

  • Molecular Targets of Active Anticancer Compounds Derived from Marine Sources.

    abstract::Over the past decades, a number of novel compounds, which are produced in the marine environment, have been found to exhibit the anticancer effects. This review focuses on molecular targets of marine-derived anticancer candidates in clinical and preclinical studies. They are kinases, transcription factors, histone dea...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Song X,Xiong Y,Qi X,Tang W,Dai J,Gu Q,Li J

    更新日期:2018-05-22 00:00:00

  • Marine Bacteria, A Source for Alginolytic Enzyme to Disrupt Pseudomonas aeruginosa Biofilms.

    abstract::Pseudomonas aeruginosa biofilms are typically associated with the chronic lung infection of cystic fibrosis (CF) patients and represent a major challenge for treatment. This opportunistic bacterial pathogen secretes alginate, a polysaccharide that is one of the main components of its biofilm. Targeting this major biof...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Daboor SM,Raudonis R,Cohen A,Rohde JR,Cheng Z

    更新日期:2019-05-24 00:00:00

  • Spiromastixones Inhibit Foam Cell Formation via Regulation of Cholesterol Efflux and Uptake in RAW264.7 Macrophages.

    abstract::Bioassay-guided evaluation shows that a deep sea-derived fungus, Spiromastix sp. MCCC 3A00308, possesses lipid-lowering activity. Chromatographic separation of a culture broth resulted in the isolation of 15 known depsidone-based analogues, labeled spiromastixones A-O (1-15). Each of these compounds was tested for its...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wu C,Chen R,Liu M,Liu D,Li X,Wang S,Niu S,Guo P,Lin W

    更新日期:2015-10-14 00:00:00

  • Characterization of a New Trioxilin and a Sulfoquinovosyl Diacylglycerol with Anti-Inflammatory Properties from the Dinoflagellate Oxyrrhis marina.

    abstract::Two new compounds-a trioxilin and a sulfoquinovosyl diacylglycerol (SQDG)-were isolated from the methanolic extract of the heterotrophic dinoflagellate Oxyrrhis marina cultivated by feeding on dried yeasts. The trioxilin was identified as (4Z,8E,13Z,16Z,19Z) -7(S),10(S),11(S)-trihydroxydocosapentaenoic acid (1), and t...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Yoon EY,Yang AR,Park J,Moon SJ,Jeong EJ,Rho JR

    更新日期:2017-02-27 00:00:00

  • Anti-Neuroinflammatory Agent, Restricticin B, from the Marine-Derived Fungus Penicillium janthinellum and Its Inhibitory Activity on the NO Production in BV-2 Microglia Cells.

    abstract::A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2-5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Choi BK,Jo SH,Choi DK,Trinh PTH,Lee HS,Cao VA,Van TTT,Shin HJ

    更新日期:2020-09-14 00:00:00

  • Novel Vibrio spp. Strains Producing Omega-3 Fatty Acids Isolated from Coastal Seawater.

    abstract::Omega-3 long-chain polyunsaturated fatty acids (LC-PUFAs), such as eicosapentaenoic acid (EPA) (20:5n-3) and docosahexaenoic acid (DHA) (22:6n-3), are considered essential for human health. Microorganisms are the primary producers of omega-3 fatty acids in marine ecosystems, representing a sustainable source of these ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Estupiñán M,Hernández I,Saitua E,Bilbao ME,Mendibil I,Ferrer J,Alonso-Sáez L

    更新日期:2020-02-01 00:00:00

  • Marine-Inspired Bis-indoles Possessing Antiproliferative Activity against Breast Cancer; Design, Synthesis, and Biological Evaluation.

    abstract::Diverse indoles and bis-indoles extracted from marine sources have been identified as promising anticancer leads. Herein, we designed and synthesized novel bis-indole series 7a-f and 9a-h as Topsentin and Nortopsentin analogs. Our design is based on replacing the heterocyclic spacer in the natural leads by a more flex...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Eldehna WM,Hassan GS,Al-Rashood ST,Alkahtani HM,A Almehizia A,Al-Ansary GH

    更新日期:2020-04-02 00:00:00

  • Indole diterpenoids and isocoumarin from the fungus, Aspergillus flavus, isolated from the prawn, Penaeus vannamei.

    abstract::Two new indole-diterpenoids (1 and 2) and a new isocoumarin (3), along with the known β-aflatrem (4), paspalinine (5), leporin B (6), α-cyclopiazonic acid (7), iso-α-cyclopiazonic acid (8), ditryptophenaline (9), aflatoxin B1 (10), 7-O-acetylkojic acid (11) and kojic acid (12), were isolated from the fermentation brot...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Sun K,Li Y,Guo L,Wang Y,Liu P,Zhu W

    更新日期:2014-06-30 00:00:00

  • Laminariales Host Does Impact Lipid Temperature Trajectories of the Fungal Endophyte Paradendryphiella salina (Sutherland.).

    abstract::Kelps are colonized by a wide range of microbial symbionts. Among them, endophytic fungi remain poorly studied, but recent studies evidenced yet their high diversity and their central role in algal defense against various pathogens. Thus, studying the metabolic expressions of kelp endophytes under different conditions...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Vallet M,Meziane T,Thiney N,Prado S,Hubas C

    更新日期:2020-07-22 00:00:00

  • Conversion of Chitin to Defined Chitosan Oligomers: Current Status and Future Prospects.

    abstract::Chitin is an abundant polysaccharide primarily produced as an industrial waste stream during the processing of crustaceans. Despite the limited applications of chitin, there is interest from the medical, agrochemical, food and cosmetic industries because it can be converted into chitosan and partially acetylated chito...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Schmitz C,Auza LG,Koberidze D,Rasche S,Fischer R,Bortesi L

    更新日期:2019-08-01 00:00:00

  • Borrelidins C-E: New Antibacterial Macrolides from a Saltern-Derived Halophilic Nocardiopsis sp.

    abstract::Chemical investigation of a halophilic actinomycete strain belonging to the genus Nocardiopsis inhabiting a hypersaline saltern led to the discovery of new 18-membered macrolides with nitrile functionality, borrelidins C-E (1-3), along with a previously reported borrelidin (4). The planar structures of borrelidins C-E...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Kim J,Shin D,Kim SH,Park W,Shin Y,Kim WK,Lee SK,Oh KB,Shin J,Oh DC

    更新日期:2017-06-06 00:00:00

  • Non-traditional vectors for paralytic shellfish poisoning.

    abstract::Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Deeds JR,Landsberg JH,Etheridge SM,Pitcher GC,Longan SW

    更新日期:2008-06-10 00:00:00

  • Reclamation of Marine Chitinous Materials for the Production of α-Glucosidase Inhibitors via Microbial Conversion.

    abstract::Six kinds of chitinous materials have been used as sole carbon/nitrogen (C/N) sources for producing α-glucosidase inhibitors (aGI) by Paenibacillus sp. TKU042. The aGI productivity was found to be highest in the culture supernatants using demineralized crab shell powder (deCSP) and demineralized shrimp shell powder (d...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Nguyen VB,Wang SL

    更新日期:2017-11-07 00:00:00

  • 5-Episinuleptolide Decreases the Expression of the Extracellular Matrix in Early Biofilm Formation of Multi-Drug Resistant Acinetobacter baumannii.

    abstract::Nosocomial infections and increasing multi-drug resistance caused by Acinetobacter baumannii have been recognized as emerging problems worldwide. Moreover, A. baumannii is able to colonize various abiotic materials and medical devices, making it difficult to eradicate and leading to ventilator-associated pneumonia, an...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Tseng SP,Hung WC,Huang CY,Lin YS,Chan MY,Lu PL,Lin L,Sheu JH

    更新日期:2016-07-29 00:00:00

  • New Monoterpenoids and Polyketides from the Deep-Sea Sediment-Derived Fungus Aspergillus sydowii MCCC 3A00324.

    abstract::Chemical study of the secondary metabolites of a deep-sea-derived fungus Aspergillus sydowii MCCC 3A00324 led to the isolation of eleven compounds (1-11), including one novel (1) and one new (2) osmane-related monoterpenoids and two undescribed polyketides (3 and 4). The structures of the metabolites were determined b...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Niu S,Yang L,Chen T,Hong B,Pei S,Shao Z,Zhang G

    更新日期:2020-11-17 00:00:00

  • NMR-based metabolomic analysis of spatial variation in soft corals.

    abstract::Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using ¹H-NMR spectroscopy coupled with multivariate statistical analysi...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: He Q,Sun R,Liu H,Geng Z,Chen D,Li Y,Han J,Lin W,Du S,Deng Z

    更新日期:2014-03-28 00:00:00

  • Polysaccharide from Codium fragile Induces Anti-Cancer Immunity by Activating Natural Killer Cells.

    abstract::Natural polysaccharides exhibit beneficial immune modulatory effects, including immune stimulatory and anti-cancer activities. In this study, we examined the effect of Codium fragile polysaccharide (CFP) on natural killer (NK) cell activation, and its effect on tumor-bearing mice. Intravenous CFP treatment of C57BL/6 ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Park HB,Hwang J,Zhang W,Go S,Kim J,Choi I,You S,Jin JO

    更新日期:2020-12-08 00:00:00

  • Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

    abstract::Two new bicyclogermacrenes, capgermacrenes A (1) and B (2), were isolated with two known compounds, palustrol (3) and litseagermacrane (4), from a population of Bornean soft coral Capnella sp. The structures of these metabolites were elucidated based on spectroscopic data. Compound 1 was found to inhibit the accumulat...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Phan CS,Ng SY,Kim EA,Jeon YJ,Palaniveloo K,Vairappan CS

    更新日期:2015-05-19 00:00:00

  • Ascidian Toxins with Potential for Drug Development.

    abstract::Ascidians (tunicates) are invertebrate chordates, and prolific producers of a wide variety of biologically active secondary metabolites from cyclic peptides to aromatic alkaloids. Several of these compounds have properties which make them candidates for potential new drugs to treat diseases such as cancer. Many of the...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Watters DJ

    更新日期:2018-05-13 00:00:00

  • 5-Hydroxycyclopenicillone, a New β-Amyloid Fibrillization Inhibitor from a Sponge-Derived Fungus Trichoderma sp. HPQJ-34.

    abstract::Abstract: A new cyclopentenone, 5-hydroxycyclopeni cillone (1), was isolated together with three known compounds, ar-turmerone (2), citreoisocoumarin (3), and 6-O-methyl-citreoisocoumarin (4), from a culture of the sponge-derived fungus Trichoderma sp. HPQJ-34. The structures of 1-4 were characterized using comprehens...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Fang F,Zhao J,Ding L,Huang C,Naman CB,He S,Wu B,Zhu P,Luo Q,Gerwick WH,Yan X,Wang Q,Zhang Z,Cui W

    更新日期:2017-08-19 00:00:00

  • Comparative Analysis of Culture Conditions for the Optimization of Carotenoid Production in Several Strains of the Picoeukaryote Ostreococcus.

    abstract::Microalgae are promising sources for the sustainable production of compounds of interest for biotechnologies. Compared to higher plants, microalgae have a faster growth rate and can be grown in industrial photobioreactors. The microalgae biomass contains specific metabolites of high added value for biotechnology such ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Guyon JB,Vergé V,Schatt P,Lozano JC,Liennard M,Bouget FY

    更新日期:2018-02-28 00:00:00

  • Rhodoptilometrin, a Crinoid-Derived Anthraquinone, Induces Cell Regeneration by Promoting Wound Healing and Oxidative Phosphorylation in Human Gingival Fibroblast Cells.

    abstract::Gingival recession (GR) potentially leads to the exposure of tooth root to the oral cavity microenvironment and increases susceptibility to dental caries, dentin hypersensitivity, and other dental diseases. Even though many etiological factors were reported, the specific mechanism of GR is yet to be elucidated. Given ...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Tseng CC,Lai YC,Kuo TJ,Su JH,Sung PJ,Feng CW,Lin YY,Chen PC,Tai MH,Cheng SY,Kuo HM,Wen ZH

    更新日期:2019-02-27 00:00:00

  • Two New Terpenoids from Talaromyces purpurogenus.

    abstract::A new sesquiterpenoid 9,10-diolhinokiic acid (1) and a new diterpenoid roussoellol C (2), together with 4 known compounds, were isolated from the extracts of laboratory cultures of marine-derived fungus Talaromyces purpurogenus. 9,10-diolhinokiic acid is the first thujopsene-type sesquiterpenoid containing a 9,10-diol...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Wang W,Wan X,Liu J,Wang J,Zhu H,Chen C,Zhang Y

    更新日期:2018-05-02 00:00:00

  • The Immune Activity of PT-Peptide Derived from Anti-Lipopolysaccharide Factor of the Swimming Crab Portunus trituberculatus Is Enhanced when Encapsulated in Milk-Derived Extracellular Vesicles.

    abstract::PT-peptide is derived from the anti-lipopolysaccharide factor of the swimming crab Portunus trituberculatus. The peptide, consisting of 34 amino acids, contains a lipopolysaccharide binding domain. In this study, we investigated the effect of PT-peptide encapsulated in raw milk-derived extracellular vesicles (EVs), de...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Lee BH,Chen BR,Huang CT,Lin CH

    更新日期:2019-04-26 00:00:00

  • New Invasive Nemertean Species (Cephalothrix Simula) in England with High Levels of Tetrodotoxin and a Microbiome Linked to Toxin Metabolism.

    abstract::The marine nemertean Cephalothrix simula originates from the Pacific Ocean but in recent years has been discovered in northern Europe. The species has been associated with high levels of the marine neurotoxin Tetrodotoxin, traditionally associated with Pufferfish Poisoning. This study reports the first discovery of tw...

    journal_title:Marine drugs

    pub_type: 杂志文章


    authors: Turner AD,Fenwick D,Powell A,Dhanji-Rapkova M,Ford C,Hatfield RG,Santos A,Martinez-Urtaza J,Bean TP,Baker-Austin C,Stebbing P

    更新日期:2018-11-16 00:00:00

  • Briarane diterpenoids isolated from gorgonian corals between 2011 and 2013.

    abstract::The structures, names, bioactivities and references of 138 briarane-type diterpenoids, including 87 new compounds, are summarized in this review. All the briarane-type compounds mentioned in this review article were obtained from gorgonian corals including the genus Briareum, Dichotella, Junceella and Verrucella. Some...

    journal_title:Marine drugs

    pub_type: 杂志文章,评审


    authors: Sheu JH,Chen YH,Chen YH,Su YD,Chang YC,Su JH,Weng CF,Lee CH,Fang LS,Wang WH,Wen ZH,Wu YC,Sung PJ

    更新日期:2014-04-10 00:00:00